Random ethylene oxide copolymer and non-random alkylene oxide(s) polymer with bioactive agent
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
C08L-071/02
출원번호
US-0883171
(2010-09-15)
등록번호
US-8124687
(2012-02-28)
발명자
/ 주소
Wellisz, Tadeusz
Fisher, Timothy C.
Armstrong, Jonathan K.
Cambridge, John
출원인 / 주소
Syncera, Inc.
대리인 / 주소
Nixon & Vanderhye P.C.
인용정보
피인용 횟수 :
3인용 특허 :
60
초록▼
A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homop
A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.
대표청구항▼
1. A composition for use in medicine or surgery, which is comprised of (i) at least one bioactive agent; (ii) at least one random copolymer having a molecular mass of at least 5 kg/mol, and comprising ethylene oxide and one or more other alkylene oxide(s); and (iii) at least one non-random polymer c
1. A composition for use in medicine or surgery, which is comprised of (i) at least one bioactive agent; (ii) at least one random copolymer having a molecular mass of at least 5 kg/mol, and comprising ethylene oxide and one or more other alkylene oxide(s); and (iii) at least one non-random polymer comprising one or more alkylene oxide(s). 2. The composition of claim 1, wherein said bioactive agent is selected from the group consisting of analgesics, anesthetics, antibiotics, antibodies, antigens, steroidal or non-steroidal anti-inflammatory agents, antiseptics, bone growth factor or morphogenic proteins, chemotherapeutics, imaging and contrast agents, and radiotherapeutics. 3. A method of using the composition of claim 1, which comprises administering said composition to a subject. 4. The method according to claim 3, wherein said composition is administered at least orally, parenterally, or topically to the subject. 5. The method according to claim 3, wherein said composition is administered as a suppository to the subject's mucosa. 6. The method according to claim 3, wherein said composition is administered during surgery by insertion into a body cavity or tissue of the subject. 7. A product useful for medicine or surgery, which comprises (a) a device selected from the group consisting of anchors, catheters, implants, plates, prostheses, screws, sutures, and surgical instruments and (b) a composition comprised of (i) at least one random copolymer having a molecular mass of at least 5 kg/mol, and comprising ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprising one or more alkylene oxide(s). 8. The product of claim 7, wherein said device is made from ceramic, glass, hydroxyapatite, polyethylene, stainless steel, titanium, or any combination thereof. 9. The product of claim 7, wherein said composition further comprises a bioactive agent. 10. The product of claim 9, wherein said bioactive agent is selected from the group consisting of analgesics, anesthetics, antibiotics, antibodies, antigens, steroidal or non-steroidal anti-inflammatory agents, antiseptics, bone growth factor or morphogenic proteins, chemotherapeutics, imaging and contrast agents, and radiotherapeutics. 11. A method for medically or surgically treating a subject, which comprises inserting the product of claim 7 into the subject. 12. A composition comprised of: (i) at least one random copolymer of ethylene oxide and propylene oxide having a molecular mass of at least 5 kg/mol and (ii) at least one non-random alkylene oxide polymer selected from the group consisting of homopolymers of ethylene oxide, homopolymers of propylene oxide, block copolymers of ethylene oxide and propylene oxide, and graft copolymers of ethylene oxide and propylene oxide. 13. The composition of claim 12 further comprised of one or more additives selected from the group consisting of particles, color pigments, bioactive agents, and therapeutic drugs. 14. The composition of claim 12 further comprised of particles selected from the group consisting of polyethylene particles, hydroxyapatite particles, ceramic particles, glass particles, bone fragments, bone powder, and demineralized bone particles. 15. The composition of claim 12 further comprised of a bioactive agent selected from the group consisting of antibodies, antigens, bone growth factors, chemokines, cytokines, demineralized bone matrix, enzymes, hormones, morphogenic proteins, nucleic acids, receptors, ligands, and signaling molecules. 16. The composition of claim 12 further comprised of a therapeutic drug selected from the group consisting of analgesics, antibiotics, anti-infective drugs, anti-inflammatory drugs, and chemotherapeutic drugs. 17. An implantable medical device coated with the composition of claim 12. 18. The device of claim 17, which is a porous implant. 19. The device of claim 18, wherein said implantable medical device is a porous implant manufactured from at least one material selected from the group consisting of polyethylene, hydroxyapatite, ceramic, glass, stainless steel, titanium, and other metals. 20. The device of claim 17, which is a solid implant. 21. The device of claim 20, wherein said solid implant is selected from the group consisting of anchor, catheter, plate, prosthesis, and screw. 22. The device of claim 17, wherein said composition is further comprised of at least one bioactive agent or therapeutic drug. 23. The device of claim 17, wherein said composition is further comprised of at least one bioactive agent selected from the group consisting of antibodies, antigens, bone growth factors, chemokines, cytokines, demineralized bone matrix, enzymes, hormones, morphogenic proteins, nucleic acids, receptors, ligands, and signaling molecules. 24. The device of claim 17, wherein said composition is further comprised of at least one therapeutic drug selected from the group consisting of analgesics, antibiotics, anti-infective drugs, anti-inflammatory drugs, and chemotherapeutic drugs. 25. A composition comprised of: (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s, which are combined to form a polymer alloy. 26. The composition of claim 25, wherein said random copolymer has a molecular mass of at least 4 kg/mol. 27. The composition of claim 25, wherein said non-random polymer is a block copolymer.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (60)
Mattei Frank V. (Piscataway NJ), Absorbable coating composition for sutures.
Mattei Frank V. (Piscataway NJ) Stephenson Martin (Peterborough CAX) Gordon Allin K. (Peterborough CA CAX) Doddi Namassivaya (Upland CA), Absorbable hemostatic composition.
Mattei Frank V. (Piscataway NJ) Stephenson Martin (Peterborough CAX) Gordon Allin K. (Peterborough CA CAX) Doddi Namassivaya (Upland CA), Absorbable hemostatic composition.
Perciaccante Vincent Anthony (Long Island City NY) Landi Henry Patrick (Yorktown Heights NY), Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant.
Lhner Manfred (Bonn DEX) Posselt Klaus (Bonn DEX) Vogtle-Junkert Ute (Alfter DEX) Wagener Hans H. (Meckenheim DEX), Agents for the treatment of severe pain and preparation of said agents.
Chu, Benjamin; Hsiao, Benjamin S.; Fang, Dufei; Brathwaite, Collin, Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications.
Polson Alan M. (Fort Collins CO) Swanbom Deryl D. (Fort Collins CO) Dunn Richard L. (Fort Collins CO) Cox Charles P. (Fort Collins CO) Norton Richard L. (Fort Collins CO) Lowe Bryan K. (Fort Collins , Biodegradable implant precursor.
Jarrett Peter K. (New Haven CT) Jessup George (Brookfield CT) Rosati Louis (Norwalk CT) Martin Chris (Guildford NY AUX) Maney John W. (Spring Valley NY), Coating for tissue drag reduction.
Jarrett Peter K. (New Haven CT) Jessup George (Brookfield CT) Rosati Louis (Norwalk CT) Martin Chris (Guildford NY AUX) Maney John W. (Spring Valley NY), Coating for tissue drag reduction.
Kafrawy Adel (Rockaway NJ) Mattei Frank V. (Piscataway NJ) Shalaby Shalaby W. (Lebanon NJ), Copolymers of lactide and/or glycolide with 1,5-dioxepan-2-one.
Tjia Jane S. (Malden MA) Kelley Brian D. (Medford MA) Northey Richard P. (Ipswich MA) Philbrook C. Michael (Boston MA), Formulations for delivery of osteogenic proteins.
Klun, Thomas P.; Dunshee, Wayne K.; Schaffer, Kevin R.; Andrews, Jeffrey F.; Neu, Debra M.; Scholz, Matthew T., Hydrophilic polypropylene fibers having antimicrobial activity.
DeJuneas James V. (Hamilton Township NJ) McIntyre Gordon L. (Trenton NJ) O\Horo ; Jr. James F. (Hightstown NJ), Method of reducing breakdown in polyethylene film.
Landi Henry Patrick (Yorktown Heights NY) Perciaccante Vincent Anthony (Long Island City NY), Non-absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant.
Hostettler Fritz ; Rhum David ; Forman Michael R. ; Helmus Michael N. ; Ding Ni, Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated polymer and metal substrate materials, and coated medical devices.
Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Landrau Felix A. (Milpitas CA), Rate controlled dispenser for administering beneficial agent.
Bromberg Lev ; Lupton Elmer Cornelius (E.C.) ; Schiller Matthew E. ; Timm Mary Jo (M.J.) ; McKinney George, Responsive polymer networks and methods of their use.
Hermes Matthew E. (Easton CT) Muth Ross R. (Brookfield CT) Gustafson Darel L. (Shelton CT), Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.