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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0855542 (2007-09-14) |
등록번호 | US-8128689 (2012-03-06) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 6 인용 특허 : 573 |
Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed.
1. A stent comprising a biostable layer and a bioerodible underlying structure, wherein the biostable layer is about 5% or less of a wall thickness of a strut of the stent, wherein the bioerodible underlying structure comprises a bioerodible metal. 2. The stent of claim 1, wherein the biostable laye
1. A stent comprising a biostable layer and a bioerodible underlying structure, wherein the biostable layer is about 5% or less of a wall thickness of a strut of the stent, wherein the bioerodible underlying structure comprises a bioerodible metal. 2. The stent of claim 1, wherein the biostable layer has a thickness on average of about 10 to 20 nm. 3. The stent of claim 1, wherein the biostable layer has an average volume in the range of about 5,000 to 20,000 cubic micrometer per square millimeter of stent surface area. 4. The stent of any of claims 1-3, wherein the biostable layer comprises ceramic material. 5. The stent of claim 1, wherein the biostable layer comprises one or more metal oxides. 6. The stent of any of claims 1-3, wherein the biostable layer comprises a crystalline form of titanium oxide. 7. The stent of claim 1, wherein the biostable layer is on a surface of the stent. 8. The stent of claim 7, wherein the biostable layer is on an interior surface, an exterior surface or a sidewall. 9. The stent of claim 1, wherein at least a portion of the biostable layer is covered by a bioerodible layer. 10. The stent of claim 1, wherein the biostable layer formed by a sol-gel process. 11. The stent of claim 1, wherein the biostable layer is formed by a process comprising: modifying a selected portion of the surface of the underlying structure with hydroxyl groups;allowing the hydroxyl groups to react with one or more metal alkoxides to form a covalently-bound biostable layer of the one or more metal alkoxides;(optionally) removing excess adsorbed metal alkoxide; andhydrolyzing the covalently-bound surface of the biostable layer. 12. The stent of claim 1, wherein the biostable layer is a monolayer. 13. The stent of claim 1, comprising one or more monolayers of a metal oxide, an organic material, a polymeric material or a biological material. 14. The stent of claim 1, further comprising at least one therapeutic agent. 15. The stent of claim 14, wherein the therapeutic agent is paclitaxel. 16. A method comprising implanting the stent of claim 1 in a body passageway to stimulate the attachment of endothelial cells to the stent or control the erosion rate of the underlying structure. 17. The method of claim 16, wherein at least a portion of the stent degrades over a period of time inside the organism and releases a therapeutic agent. 18. The method of claim 16, wherein the stent is implanted in a cardiovascular passageway. 19. A stent comprising a biostable layer and a bioerodible underlying structure, wherein the biostable layer is about 5% or less of a wall thickness of a strut of the stent, wherein the bioerodible underlying structure comprises a bioerodible metal, wherein the biostable layer comprises one or more of titanium oxide, ruthenium oxide, or iridium oxide. 20. A stent comprising a biostable layer and a bioerodible underlying structure, wherein the biostable layer is about 5% or less of a wall thickness of a strut of the stent, wherein the biostable layer comprises a plurality of nodules about 15-20 nm in size. 21. The stent of claim 1, wherein the bioerodible underlying structure comprises magnesium or an alloy thereof.
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