Systems and methods for breast cancer detection and risk assessment
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-033/48
G01N-021/00
출원번호
US-0018271
(2011-01-31)
등록번호
US-8133737
(2012-03-13)
발명자
/ 주소
Krepinsky, Jiri Jan
Furrer, Rudolf
Yeung, Ka Sing
출원인 / 주소
Atossa Genetics, Inc.
대리인 / 주소
Wilson, Sonsini, Goodrich & Rosati
인용정보
피인용 횟수 :
0인용 특허 :
32
초록▼
The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde dete
The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without any prewashing. The appearance in breast fluids of a marker that is detected by an aldehyde detecting reagent, such as a Schiff's reagent, correlates very well with the disease status of the breast cancer subjects from which the fluids were obtained. Screening test kits are also provided.
대표청구항▼
1. A method of screening a patient for breast cancer or for elevated breast cancer risk, comprising: providing a solid support configured to receive a volume of breast aspirate fluid from the patient; wherein the volume of breast aspirate fluid is obtained from a breast duct of a patient;wherein the
1. A method of screening a patient for breast cancer or for elevated breast cancer risk, comprising: providing a solid support configured to receive a volume of breast aspirate fluid from the patient; wherein the volume of breast aspirate fluid is obtained from a breast duct of a patient;wherein the volume of breast aspirate fluid is obtained at least in part by the application of suction within or along the breast of the patient;wherein the solid support comprises an aldehyde detecting agent; anddetecting a change in a detectable property produced by contacting the volume of breast aspirate fluid to the aldehyde detecting reagent on the solid support; wherein the detection of a change in a detectable property produced by treating the breast fluid with the aldehyde detecting reagent compared to a control is indicative of a patient having breast cancer or elevated breast cancer risk; andwherein the volume of breast aspirate fluid does not undergo pretreatment or modification before being placed on the solid support. 2. The method of claim 1, wherein the solid support comprises a pad. 3. The method of claim 1, wherein the detectable property comprises at least one of: color, spectral properties, spectral absorption, fluorescence, chemi-luminescence, mass spectral properties or chromatographic properties. 4. The method of claim 1, wherein the aldehyde detecting reagent comprises Schiff's reagent. 5. The method of claim 1, wherein the volume of breast aspirate fluid is additionally screened for the presence of at least one additional marker of breast cancer. 6. The method of claim 5, wherein the solid support comprises at least one additional reagent for detection of the at least one additional marker. 7. The method of claim 1, wherein the solid support comprises a water-insoluble substrate. 8. The method of claim 1, wherein a shape of the solid support is generally a tube, test plate, well, beads, disc or sphere. 9. A method for monitoring the effectiveness of a chemotherapy treatment of a patient with breast cancer, comprising: treating a sample of breast fluid secreted from a nipple of a patient undergoing chemotherapy with an aldehyde-detecting reagent;detecting a change in a detectable property produced by treating the sample of breast fluid with the aldehyde-detecting reagent;wherein the detectable property comprises one or more of: color, spectral properties, spectral absorption, fluorescence, chemi-luminescence, mass spectral properties or chromatographic properties;wherein the sample of breast fluid is treated directly with the aldehyde-detecting reagent, such that the breast fluid does not undergo pretreatment or modification prior to contacting the aldehyde-detecting reagent;and wherein a significant reduction in the detectable property compared to a control is indicative that a chemotherapy treatment is generally effective. 10. The method of claim 9, wherein the aldehyde-detecting reagent is positioned on a solid support. 11. The method of claim 10, wherein the solid support comprises a pad. 12. The method of claim 9, wherein the aldehyde detecting reagent comprises Schiff's reagent. 13. The method of claim 9, wherein the breast fluid is additionally screened for the presence of at least one additional marker of breast cancer. 14. The method of claim 5, wherein the additional marker of breast cancer is an aldehyde marker comprising low molecular weight aldehydes that are soluble in water.
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이 특허에 인용된 특허 (32)
Hattori Morihisa (Nishinomiya JPX), Adhesive pad for use on human body.
Burchiel Scott W. (Albuquerque NM) Crockford David R. (Nashua NH) Rhodes Buck A. (Albuquerque NM), Composition and method for cancer detection in humans.
Krepinsky Jiri J. (810 Srigley Street Newmarket CAX L3Y 1X7) Chociej Jacek (43 Valleywoods Rd. #89 Toronto CAX M3A 2R5) Kandel Gabor P. (430 Heath St. East Toronto CAX M4G 1B5) Yeung Ka Sing (810 Sri, Screening test for early detection of colorectal cancer.
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