Poly(orthoester) polymers, and methods of making and using same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08G-067/02
C08G-059/00
C08G-065/00
C08G-065/34
출원번호
US-0968004
(2010-12-14)
등록번호
US-8133968
(2012-03-13)
발명자
/ 주소
Alkatout, Julie A.
Benz, Michael Eric
Sparer, Randall V.
출원인 / 주소
Medtronic, Inc.
대리인 / 주소
Hohenshell, Jeffrey J.
인용정보
피인용 횟수 :
0인용 특허 :
77
초록▼
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are b
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
대표청구항▼
1. A method of preparing a polymer, the method comprising: combining components comprising: at least one hydroxy-containing compound of the formula (Formula I) HO-A-OH; andat least one orthoester of the formula (Formula II) under conditions effective to polymerize at least a portion of the orthoest
1. A method of preparing a polymer, the method comprising: combining components comprising: at least one hydroxy-containing compound of the formula (Formula I) HO-A-OH; andat least one orthoester of the formula (Formula II) under conditions effective to polymerize at least a portion of the orthoester; and removing byproducts comprising R14OH to provide a polymer comprising two or more repeat units of the formula (Formula VI): wherein each R9 and R10 independently represents hydrogen or an organic group;each R11, R13, and R14 independently represents an organic group;n=0;each A independently represents a group of the formula (Formula III) —Ar2—C(R8)2—Ar2—(B)m—; andwherein each Ar2 independently represents an arylene group, each R8 independently represents a methyl group, B represents an aromatic-containing organic group having a linking oxygen attached to the aromatic ring, and m=0 or 1, wherein at least one A represents a structure of the formula: 2. The method of claim 1 wherein the components further comprise at least one diol different than at least one hydroxy-containing compound of the formula (Formula I). 3. The method of claim 1 wherein combining components further comprises combining a solvent that forms an azeotrope with R14OH. 4. The method of claim 3 wherein removing byproducts comprises removing byproducts under azeotropic conditions. 5. The method of claim 1 wherein combining components further comprises combining a polymerization agent. 6. The method of claim 5 wherein the polymerization agent comprises a Lewis acid or a Brønsted-Lowry acid. 7. The method of claim 6 wherein the Brønsted-Lowry acid is selected from the group consisting of hydrochloric acid, p-toluenesulfonic acid, methanesulfonic acid, trifluoromethanesulfonic acid, camphorsulfonic acid, and combinations thereof. 8. The method of claim 6 wherein the Lewis acid comprises an element selected from the group consisting of Al, Fe, B, Zn, Sb, Ti, Cu, Sn, Si, and combinations thereof. 9. The method of claim 5 wherein the polymerization agent comprises an organometallic compound or a metal salt. 10. The method of claim 9 wherein the metal salt is selected from the group consisting of metal halides, metal pseudohalides, metal sulfonates, metal carboxylates, metal carbonates, and combinations thereof. 11. The method of claim 10 wherein the metal salt comprises a metal selected from the group consisting of Zn, Cs, and combinations thereof. 12. The method of claim 5 wherein the polymerization agent comprises a plurality of sites for initiating polymerization. 13. The method of claim 1 wherein combining components further comprises combining an additional polymerizable compound selected from the group consisting of ketene acetals, monofunctional orthoesters, polyfunctional orthoesters, imagable compounds, compounds having latent reactive sites, and combinations thereof. 14. The method of claim 13 wherein the additional polymerizable compound is an orthoester different than the at least one orthoester. 15. The method of claim 1 wherein the polymer can be further reacted as a soft segment of a segmented polymer selected from the group consisting of polyurethanes, polyethylenes, polycarbonates, polyureas, and combinations thereof. 16. The method of claim 1 wherein conditions effective to polymerize comprise combining at least a portion of the components without adding a solvent. 17. The method of claim 1 wherein conditions effective to polymerize comprise combining at least a portion of the components in a dry organic solvent. 18. The method of claim 1 wherein conditions effective to polymerize comprise combining at least a portion of the components under an inert atmosphere.
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