IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0925689
(2007-10-26)
|
등록번호 |
US-8135548
(2012-03-13)
|
발명자
/ 주소 |
- Breton, Marc D.
- Kovatchev, Boris P.
- Budiman, Erwin S.
- Doniger, Kenneth J.
|
출원인 / 주소 |
- Abbott Diabetes Care Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
8 인용 특허 :
254 |
초록
▼
A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the determined probability exceeds a
A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the determined probability exceeds a predetermined threshold level, and generating a first output signal associated with the verification of the presence of signal attenuation is provided. Also provided are systems and kits.
대표청구항
▼
1. A computer implemented method for detecting early signal attenuation in a glucose sensor, comprising: receiving a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time peri
1. A computer implemented method for detecting early signal attenuation in a glucose sensor, comprising: receiving a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion;determining a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement;determining a probability of early signal attenuation associated with the first plurality of glucose sensor related signals;determining a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured;receiving a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time;verifying the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level; andgenerating a first output signal with a processor associated with the verification of the presence of early signal attenuation. 2. The method of claim 1 wherein determining the probability of early signal attenuation includes: determining one or more characteristics associated with the first plurality of glucose sensor related signals; andwherein each of the one or more characteristics has a corresponding predetermined coefficient. 3. The method of claim 1 wherein the first predetermined threshold level is user defined. 4. The method of claim 1 wherein when the determined probability does not exceed the first predetermined threshold level, generating a second output signal associated with absence of early signal attenuation condition. 5. The method of claim 1 wherein verifying the presence of early signal attenuation includes: selecting an early signal attenuation threshold level; andconfirming the presence of early signal attenuation based at least in part on a comparison of the determined sensitivity and the selected early signal attenuation threshold level. 6. The method of claim 1 wherein the sensitivity of the glucose sensor is determined as a ratio of the average of the first plurality of glucose sensor related signals and the blood glucose measurement. 7. The method of claim 1 wherein the predetermined offset time is equivalent to the first predetermined time period. 8. The method of claim 1 wherein the predetermined offset time is less than the first predetermined time period. 9. The method of claim 1 wherein a time duration of the first predetermined time period is equivalent to a time duration of the second predetermined time period. 10. The method of claim 1 further comprising: determining a second probability of early signal attenuation associated with the second plurality of glucose sensor related signals;verifying the presence of early signal attenuation in the second plurality of glucose sensor related signals when the determined second probability exceeds the first predetermined threshold level; andgenerating the first output signal associated with the verification of the presence of early signal attenuation. 11. The method of claim 2 wherein the determined one or more characteristics includes one or more of a mean value associated with the first plurality of glucose related signals, an average slope associated with the first plurality of glucose related signals, a standard deviation associated with the first plurality of glucose related signals, an average elapsed time from insertion of the glucose sensor, or a variance of the first plurality of glucose related signals. 12. The method of claim 5 wherein the early signal attenuation threshold level is associated with a blood glucose measurement. 13. The method of claim 5 wherein confirming the presence of early signal attenuation includes determining that the sensitivity of the glucose sensor is less than the selected early signal attenuation threshold level. 14. The method of claim 12 wherein the blood glucose measurement include a capillary blood glucose sampling. 15. An apparatus, comprising: a data storage unit; anda processing unit operatively coupled to the data storage unit configured to receive a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion, determine a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement, determine a probability of early signal attenuation associated with the first plurality of glucose sensor related signals, determine a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured, receive a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time, verify the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level, and generate a first output signal associated with the verification of the presence of early signal attenuation. 16. The apparatus of claim 15 wherein the processing unit configured to determine the probability of early signal attenuation is configured to determine one or more characteristics associated with the first plurality of glucose sensor related signals, and to apply a predetermined coefficient to the first plurality of glucose sensor related signals. 17. The apparatus of claim 15 wherein the first predetermined threshold level is user defined. 18. The apparatus of claim 15 wherein when the determined probability does not exceed the first predetermined threshold level, the processing unit is further configured to generate a second output signal associated with absence of early signal attenuation condition. 19. The apparatus of claim 15 wherein the processing unit is further configured to select an early signal attenuation threshold level and confirm the presence of early signal attenuation based at least in part on a comparison of the determined sensitivity and the selected early signal attenuation threshold level. 20. The apparatus of claim 15 wherein the sensitivity of the glucose sensor is determined as a ratio of the average of the first plurality of glucose sensor related signals and the blood glucose measurement. 21. The apparatus of claim 15 including a user output unit operatively coupled to the processing unit to display the first output signal. 22. The apparatus of claim 16 wherein the determined one or more characteristics includes one or more mean value associated with the glucose sensor related signals, the least square slope associated with the glucose sensor related signals, a standard deviation associated with the glucose sensor related signals, an average elapsed time from positioning the analyte glucose sensor, or a variance about a least squares slope associated with the glucose sensor related signals. 23. The apparatus of claim 19 wherein the early signal attenuation threshold level is associated with a blood glucose measurement. 24. The apparatus of claim 19 wherein the processing unit is further configured to determine that the sensitivity of the glucose sensor is less than the selected early signal attenuation threshold level. 25. The apparatus of claim 23 wherein the blood glucose measurement include a capillary blood glucose sampling. 26. A system for detecting early signal attenuation in a glucose sensor, comprising: a glucose sensor for transcutaneous positioning through a skin layer of a user; anda data processing device operatively coupled to the glucose sensor, the data processing device configured to receive a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into the user, wherein the first predetermined time period occurs within the first 24 hours of insertion, determine a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement, determine a probability of the early signal attenuation associated with the first plurality of glucose sensor related signals, determine a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured, receive a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time, verify the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level, and generate a first output signal associated with the verification of the presence of early signal attenuation. 27. The system of claim 26 wherein the data processing device includes a user interface to output the first output signal associated with the verification of the presence of early signal attenuation associated with the glucose sensor.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.