IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0348589
(2009-01-05)
|
등록번호 |
US-8137736
(2012-03-20)
|
우선권정보 |
CN-2008 1 0196403 (2008-09-09) |
발명자
/ 주소 |
- Zhu, Mingwei
- Chen, Yanfeng
- Wang, Zhenlin
- Lu, Yanqing
- Ge, Haixiong
- Tang, Yuefeng
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
12 인용 특허 :
1 |
초록
▼
A novel method suitable for commercially mass production of hollow microneedle with high quality for delivery of drugs across or into biological tissue is provided. It typically includes the following processes: (1) coating an elongated template of a first material with a second material to form a c
A novel method suitable for commercially mass production of hollow microneedle with high quality for delivery of drugs across or into biological tissue is provided. It typically includes the following processes: (1) coating an elongated template of a first material with a second material to form a cover; (2) removing tips of the template and cover to form an opening in the cover; and (3) removing the template of the first material to obtain hollow microneedles of the second material. This simple, efficient and cost-effective fabrication method can mass produce hollow microneedle arrays involving no complicated and expensive equipments or techniques, which can be used in commercial fabrication of hollow needles for delivering drugs or genes across or into skin or other tissue barriers with advantages of minimal damage, painless, long-term and continuous usages.
대표청구항
▼
1. A method for fabricating a hollow microneedle comprising: (1) coating an elongated template made of a first material with a second material to form a cover;(2) removing a tip of the cover and a tip of the template to form an opening in the cover, wherein the tip of the cover and the tip of the te
1. A method for fabricating a hollow microneedle comprising: (1) coating an elongated template made of a first material with a second material to form a cover;(2) removing a tip of the cover and a tip of the template to form an opening in the cover, wherein the tip of the cover and the tip of the template are removed in a single step; and(3) removing a remaining portion the template, whereby the cover with the opening forms a hollow microneedle. 2. The method of claim 1, wherein in step (1) the first material includes inorganic materials, or organic materials, or metals, or their combinations. 3. The method of claim 1, wherein in step (1) a shape of the template includes cones or columns. 4. The method of claim 1, wherein in step (1) the coating is performed by painting, spin-coating, sputtering, pulling, electroless plating, electroplating, physical vapor deposition, chemical vapor deposition, sol-gel, or their combinations. 5. The method of claim 1, wherein in step (1) the second material includes inorganic materials, or organic materials, or metals, or their combinations, and wherein the second material is different from the first material. 6. The method of claim 1, wherein in step (1) a thickness of the cover is about 20 nm to 500 μm. 7. The method of claim 1, wherein in step (2) the removing is performed by cutting, shearing, polishing, etching, reactive ion etching, focused ion beam irradiation, lithography, laser irradiation, or their combinations. 8. The method of claim 1, wherein in step (3) the removing is performed by sintering, dissolving, melting, etching, or their combinations.
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