IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0314176
(2005-12-21)
|
등록번호 |
US-8140140
(2012-03-20)
|
발명자
/ 주소 |
- Sterling, Bernhard B.
- Braig, James R.
- Witte, Kenneth G.
- Rule, Peter
- Keenan, Richard
- Hall, W. Dale
|
출원인 / 주소 |
- OptiScan Biomedical Corporation
|
대리인 / 주소 |
Knobbe, Martens, Olson & Bear, LLP
|
인용정보 |
피인용 횟수 :
6 인용 특허 :
120 |
초록
▼
An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has
An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
대표청구항
▼
1. An apparatus for analyzing the composition of bodily fluid, the apparatus comprising: a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient;a pump unit in operative engagement with said fluid handling network, said pump unit h
1. An apparatus for analyzing the composition of bodily fluid, the apparatus comprising: a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient;a pump unit in operative engagement with said fluid handling network, said pump unit having an infusion mode in which said pump unit is operable to deliver infusion fluid to said patient through said patient end, and a sample draw mode in which said pump unit is operable to draw a sample of said bodily fluid from said patient through said patient end;a spectroscopic analyzer positioned to analyze at least a portion of the sample; anda processor in communication with or incorporated into said spectroscopic analyzer, said processor configured to execute stored program instructions to obtain measurements of two or more properties of said sample when a first analyte and a second analyte in said sample have overlapping spectral features, wherein the program instructions are configured to cause the fluid analyzer to: subject the at least a portion of the sample to a test that comprises obtaining a spectral characterization of the at least a portion of the sample;analyze results from the test to obtain a measurement of the first property of the two or more properties, the first property comprising the level of the first analyte in the at least a portion of the sample; andanalyze the at least a portion of the sample to obtain a measurement of the second property of the two or more properties by analyzing the same results from the test, the second property comprising the level of the second analyte in the at least a portion of the sample;wherein subjecting the at least a portion of the sample to the test comprises obtaining a single spectral characterization including the spectral features of both the first analyte and the second analyte. 2. The apparatus of claim 1, where said bodily fluid is blood, and where one of said two or more properties is the hematocrit. 3. The apparatus of claim 1, where said at least a portion of the sample is whole blood. 4. The apparatus of claim 1, where said at least a portion of the sample is blood plasma. 5. The apparatus of claim 1, where said pump unit comprises a first pump operable in said infusion mode but not in said sample draw mode, and a second pump operable in said sample draw mode but not in said infusion mode. 6. The apparatus of claim 1, wherein said spectroscopic analyzer is an infrared spectroscopic analyzer. 7. A method for analyzing the composition of a bodily fluid in a patient, the method comprising: drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient;directing at least a portion of the sample to a fluid analyzer connected to the fluid handling network;subjecting the at least a portion of the sample in the fluid analyzer to a spectroscopic test that is sensitive to at least a first property and a second property of the at least a portion of the sample; andanalyzing the at least a portion of the sample in the fluid analyzer to obtain two or more properties of the sample by: analyzing the results from the test to obtain a measurement of the first property of the two or more properties; andfurther analyzing the results from the same test to obtain a measurement of the second property of the two or more properties. 8. The method of claim 7, where said at least a portion includes whole blood, blood plasma, or blood serum. 9. The method of claim 7, where said two or more properties includes the presence of at least one analyte. 10. The method of claim 7, wherein said fluid analyzer is an infrared spectroscopic analyzer. 11. The method of claim 10, where the spectroscopic test includes obtaining a spectral characterization of the sample; andsaid analyzing includes determining an estimate of the concentration of two or more analytes in the sample from said spectral characterization. 12. The method of claim 7, where at least one of said two or more properties is an estimate of the concentration of an analyte, said analyzing includes: identifying one or more interferents to the estimate of the concentration of said analyte, andreducing errors in the estimate of the concentration of said analyte. 13. An apparatus for analyzing the composition of bodily fluid, the apparatus comprising: a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient;a controller in operative engagement with the fluid handling network, the controller having an infusion mode in which the controller is configured to cause the fluid handling network to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the controller is configured to cause the fluid handling network to draw a sample of the bodily fluid from the patient through the patient end;a fluid analyzer positioned to analyze at least a portion of the sample; anda processor in communication with or incorporated into the fluid analyzer, said processor configured to execute stored program instructions; to obtain measurements of two or more properties of the portion of the sample, wherein the program instructions are configured to cause the fluid analyzer to: subject the portion of the sample to an optical test that is sensitive to at least a first property and a second property of the portion of the sample;analyze results from the test to obtain a measurement of the first property; andanalyze the portion of the sample to obtain a measurement of the second property by analyzing the same results from the test. 14. The apparatus of claim 13, wherein the measurements of two or more properties comprises a measurement of the presence of at least one analyte. 15. The apparatus of claim 14, wherein the at least one analyte includes glucose. 16. The apparatus of claim 14, wherein the at least one analyte includes blood urea nitrogen (BUN), hemoglobin, or lactate. 17. The apparatus of claim 14, wherein the presence is an estimate of the concentration, further comprising stored program instructions executable by the processor to identify one or more interferents to the estimate of the concentration of at least one of analyte, and reduce errors in the estimate of the concentration of the at least one analyte. 18. The apparatus of claim 14, wherein the fluid analyzer comprises a spectroscopic analyzer configured to obtain a spectrum including spectral features of the at least one analyte. 19. The apparatus of claim 14, wherein the fluid analyzer comprises a spectroscopic analyzer configured to obtain two or more spectra, each of the two or more spectra including spectral features of the at least one analyte. 20. The apparatus of claim 13, wherein the first property comprises the level of a first analyte in the at least a portion of the sample, and wherein the second property comprises the level of a second analyte in the at least a portion of the sample.
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