IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0771439
(2010-04-30)
|
등록번호 |
US-8148424
(2012-04-03)
|
발명자
/ 주소 |
- Sanders, Bob G.
- Kline, Kimberly
- Yu, Weiping
|
출원인 / 주소 |
- Research Development Foundation
|
대리인 / 주소 |
Fulbright & Jaworski L.L.P.
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인용정보 |
피인용 횟수 :
0 인용 특허 :
35 |
초록
▼
The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy
The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
대표청구항
▼
1. A pharmaceutical composition comprising a compound of the formula: wherein: R1 is hydroxy or methoxy;R2 and R3 are independently hydrogen or methyl, and a pharmaceutically acceptable carrier. 2. The pharmaceutical composition of claim 1, wherein R1 is hydroxy. 3. The pharmaceutical composition o
1. A pharmaceutical composition comprising a compound of the formula: wherein: R1 is hydroxy or methoxy;R2 and R3 are independently hydrogen or methyl, and a pharmaceutically acceptable carrier. 2. The pharmaceutical composition of claim 1, wherein R1 is hydroxy. 3. The pharmaceutical composition of claim 1, wherein R1 is methoxy. 4. The pharmaceutical composition of claim 1, wherein R2 is hydrogen. 5. The pharmaceutical composition of claim 1, wherein R2 is methyl. 6. The pharmaceutical composition of claim 1, wherein R3 is hydrogen. 7. The pharmaceutical composition of claim 1, wherein R3 is methyl. 8. The pharmaceutical composition of claim 1, wherein the compound is 9. The pharmaceutical composition of claim 1, wherein the compound is
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