A device for inhalation of at least one air stream carrying a dose of medicament powder is provided. The device includes a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region includes a cavity opening
A device for inhalation of at least one air stream carrying a dose of medicament powder is provided. The device includes a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface region includes a cavity opening into said powder-containing cavity. The passing of an air stream along said flat surface region and outside said cavity generates an eddy in the cavity and the generated eddy contributes to deaggregation of the powder in said cavity and emptying of the powder from said cavity. Furthermore, a shear driven cavity principle is used in conjunction with such a device and a method of releasing medicament powder.
대표청구항▼
1. An inhalation device for enabling deaggregation of a medicament powder during dispensing of the medicament powder, the device comprising: an inlet port end for receiving an intake of air;a mouthpiece for delivering the medicament powder to a user;a cavity containing the medicament powder; anda fl
1. An inhalation device for enabling deaggregation of a medicament powder during dispensing of the medicament powder, the device comprising: an inlet port end for receiving an intake of air;a mouthpiece for delivering the medicament powder to a user;a cavity containing the medicament powder; anda flow passage including a flat surface region having an opening into the cavity_and a top surface located generally opposite the flat surface region and extending generally from upstream of the opening to downstream of the opening, wherein the top surface is substantially free of any protrusion extending into the flow passage and an air stream passing between the top surface and the flat surface region and substantially outside the cavity will generate a cylindrical eddy in the cavity, such that the generated cylindrical eddy contributes to deaggregation of the medicament powder in the cavity and emptying of the medicament powder from the cavity,wherein the cavity has a substantially straight first edge on the flat surface region and a substantially straight second edge on the flat surface region and the flow passage has opposing side surfaces extending along sides of the opening, at least part of the opposing side surfaces extending along sides of the opening being arranged in a diverging relationship such that the flow passage broadens in the direction of the air stream. 2. The inhalation device of claim 1, wherein the first and second edges extend in the general direction of the air stream. 3. The inhalation device of claim 1, wherein the first and second edges extend generally transverse to the direction of the air stream. 4. The inhalation device of claim 1, wherein the cavity has a cavity length in a direction of flow of the air stream and a cavity width that is transverse to the direction of the air stream, such that the cavity has a quadratic cross-section defined by the cavity length and the cavity width. 5. The inhalation device of claim 1, wherein the cavity has a cavity length in a direction of flow of the air stream and a cavity width that is transverse to the direction of the air stream, such that the cavity has a rectangular cross-section defined by the cavity length and the cavity width. 6. The inhalation device of claim 1, wherein the cavity has a cavity length in a direction of flow of the air stream and a cavity depth defined by the distance to the bottom of the cavity, wherein the cavity length is in the range of 85% to 135% of the cavity depth. 7. The inhalation device of claim 6, wherein the cavity length is in the range of 115% to 135% of the cavity depth. 8. The inhalation device of claim 1, wherein the cavity has a cavity length in a direction of flow of the air stream and a first cavity width along at least one edge of the cavity transverse to the direction of the air stream, wherein the first cavity width is in the range of 35% to 45% of the cavity length. 9. The inhalation device of claim 1, wherein the cavity has inner walls defining corners that extend downward from the top of the cavity to the bottom of the cavity, wherein the downward corners define a sharp angle at which two of the inner walls meet. 10. The inhalation device of claim 9, wherein the sharp angle defines a substantially right angle, and wherein the cavity has a first bottom edge defined by a downstream wall of the cavity extending transverse to the air stream at the bottom of the cavity and a second bottom edge defined by an upstream wall of the cavity extending transverse to the air stream at the bottom of the cavity, wherein the first and second bottom edges have a curved shape and a flat planar region extending therebetween. 11. The inhalation device of claim 1, wherein the cavity has a headspace defined by the distance between the top of the cavity and the top of the medicament powder in an initial condition, the headspace being at least 1.0 mm. 12. The inhalation device of claim 1, wherein the cavity is part of a cavity structure having a plurality of cavities containing respective doses of medicament powder, the inhalation device further including: a cavity holder for holding the cavity structure, wherein the plurality of cavities are arranged in an annular pattern in the cavity structure,wherein the cavity structure holder forms part of at least one side portion of the flow passage. 13. The inhalation device of claim 1, the cavity further including: a downstream wall extending transverse to the air stream, wherein the downstream wall is positioned at a first inclination angle relative to the direction of flow of the air stream, wherein the first angle is greater than zero degrees. 14. The inhalation device of claim 13, further including an upstream wall extending transverse to the air stream, wherein the upstream wall is positioned at a second inclination angle relative to the direction of flow of the air stream, wherein the second angle is greater than zero degrees. 15. An inhalation device for enabling deaggregation of a medicament powder during dispensing of the medicament powder, the device comprising: an inlet port end for receiving an intake of air;a mouthpiece for delivering the medicament powder to a user;a cavity containing the medicament powder; anda flow passage including a flat surface region having an opening into the cavity_and a top surface located generally opposite the flat surface region and extending generally from upstream of the opening to downstream of the opening, wherein the top surface is substantially free of any protrusion extending into the flow passage and an air stream passing parallel and adjacent to the flat surface region is directed over the cavity to generate a cylindrical eddy in the cavity, such that the generated cylindrical eddy initially forms in a downstream region of the cavity to deaggregate and empty the medicament powder from the downstream region of the cavity,wherein the cavity has a cavity length in a direction of flow of the air stream and a cavity depth defined by the distance to the bottom of the cavity, wherein the cavity length is in the range of 85% to 135% of the cavity depth and the flow passage has opposing side surfaces extending along sides of the opening, at least part of the opposing side surfaces extending along sides of the opening being arranged in a diverging relationship such that the flow passage broadens in the direction of the air stream. 16. The inhalation device of claim 15, wherein the emptying of the medicament powder from the downstream region of the cavity progresses generally from an upper downstream region of the cavity to a lower upstream region of the cavity. 17. The inhalation device of claim 15, wherein the flat surface region, the top surface, and the opposing side surfaces are generally perpendicular to each other such that the flow passage located about the cavity has a generally rectangular cross-section. 18. An inhalation device for enabling deaggregation of a medicament powder during dispensing of the medicament powder, the device comprising: an inlet port end for receiving an intake of air;a mouthpiece for delivering the medicament powder to a user;a cavity containing the medicament powder and a headspace located above the medicament powder; anda flow passage including a flat surface region having an opening into the cavity_and a top surface located generally opposite the flat surface region and extending generally from upstream of the opening to downstream of the opening, wherein the top surface is substantially free of any protrusion extending into the flow passage and an air stream passing parallel and adjacent to the flat surface region is directed over the cavity to generate a cylindrical eddy in the cavity, such that the generated cylindrical eddy initially forms in a downstream region of the headspace and moves upstream in the cavity to deaggregate the medicament powder in the cavity entrained by the generated cylindrical eddy,wherein the cavity has a cavity length in a direction of flow of the air stream and a first cavity width along at least one edge of the cavity transverse to the direction of the air stream, wherein the first cavity width is less than 50% of the cavity length and the flow passage has opposing side surfaces extending along sides of the opening, at least part of the opposing side surfaces extending along sides of the opening being arranged in a diverging relationship such that the flow passage broadens in the direction of the air stream. 19. The inhalation device of claim 18, wherein the top surface extends generally from the inlet port to downstream of the opening. 20. The inhalation device of claim 18, wherein a length of the top surface in the general direction of the air stream is at least twice a length of the opening in the general direction of the air stream.
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이 특허에 인용된 특허 (20)
Baum Eric A. (both c/o Minnesota 3M Research Limited ; The Pinnacles Harlow ; Essex GB2) Davies Leslie J. (both c/o Minnesota 3M Research Limited ; The Pinnacles Harlow ; Essex GB2 CM19 5AE) Kirk Wil, Breath actuated devices for administering powdered medicaments.
Kirk William F. (Loughborough GBX) Wass Anthony C. L. (Duddington GBX) Baum Eric A. (Bishops Stortford GBX) Tansey Ian P. (Barrow on Soare Loughborough GBX) Meredith William G. (Rothley GBX), Powder inhalation device.
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