IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0528980
(2006-09-27)
|
등록번호 |
US-8153162
(2012-04-10)
|
발명자
/ 주소 |
- Tseng, Scheffer
- He, Hua
- Li, Wei
|
출원인 / 주소 |
|
대리인 / 주소 |
Wilson, Sonsini, Goodrich & Rosati
|
인용정보 |
피인용 횟수 :
48 인용 특허 :
52 |
초록
▼
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtai
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
대표청구항
▼
1. A pharmaceutical composition comprising: (a) an AM preparation prepared from pulverized or ground amniotic membrane isolated from placenta that is frozen or previously frozen, comprising: i. high molecular weight hyaluronan (HA) that is cross-linked by a covalent bond to the heavy chain of inter-
1. A pharmaceutical composition comprising: (a) an AM preparation prepared from pulverized or ground amniotic membrane isolated from placenta that is frozen or previously frozen, comprising: i. high molecular weight hyaluronan (HA) that is cross-linked by a covalent bond to the heavy chain of inter-α-trypsin inhibitor (IαI), the high molecular weight HA having a molecular weight greater than 1000 kDa;ii. tumor necrosis factor-stimulated gene 6 (TSG-6);iii. pentraxin (PTX-3); andiv. thrombospondin (TSP-1); and(b) a pharmaceutically acceptable diluent, excipient, or carrier; wherein the ratio of total protein to HA in the pharmaceutical composition is less than 100 parts protein: 1 part HA. 2. The pharmaceutical composition of claim 1, further comprising Smad7. 3. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated as a non-solid dosage form. 4. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated as a solution, suspension, aerosol, paste, ointment, oil, emulsion, cream, lotion, gel, or combination thereof. 5. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated for ophthalmic administration. 6. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is for topical administration. 7. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is for systemic administration. 8. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated as a solid dosage form. 9. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated as a solid dosage form, and wherein the solid dosage form is for inserting between an eye and an eyelid, or in a conjunctival sac. 10. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated as a solid oral dosage form. 11. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is formulated for controlled release.
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