IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0214533
(2008-06-18)
|
등록번호 |
US-8160695
(2012-04-17)
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발명자
/ 주소 |
- Dacey, Jr., Ralph G.
- Della Rocca, Gregory J.
- Derdeyn, Colin P.
- Dowling, Joshua L.
- Goodall, Eleanor V.
- Hyde, Roderick A.
- Ishikawa, Muriel Y.
- Kare, Jordin T.
- Leuthardt, Eric C.
- Myhrvold, Nathan P.
- Smith, Michael A.
- Wood, Jr., Lowell L.
- Wood, Victoria Y. H.
- Zipfel, Gregory J.
|
출원인 / 주소 |
- The Invention Science Fund I, LLC
|
인용정보 |
피인용 횟수 :
9 인용 특허 :
127 |
초록
▼
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction bl
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.
대표청구항
▼
1. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to:distinguish a low activity state of the
1. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to:distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; andgenerate a chemical blocking agent control signal for driving delivery of a chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; anda chemical blocking agent source configured to deliver the chemical blocking agent responsive to the chemical blocking agent control signal. 2. The neural modulation system of claim 1, including a sensor operatively connected to the signal input structure and configured to generate the signal indicative of the activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure responsive to an activity of the at least a portion of the body of the subject. 3. The neural modulation system of claim 1, wherein the chemical blocking agent source is configured to produce blockage of a subset of nerve fibers in the peripheral neural structure of the subject responsive to the chemical blocking agent control signal. 4. The neural modulation system of claim 3, wherein the subset of nerve fibers in the peripheral neural structure of the subject includes at least one of nerve fibers within a selected diameter range, nerve fibers within a selected spatial distribution within the peripheral neural structure, or nerve fibers including a selected molecular feature. 5. The neural modulation system of claim 1, wherein the chemical blocking agent source is configured to deliver two or more chemical agents. 6. The neural modulation system of claim 1, wherein the chemical blocking agent source is configured to deliver one or more chemical agents at two or more locations. 7. The neural modulation system of claim 1, wherein the signal processing portion is configured to: determine an onset of the low activity state; and generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject at least intermittently responsive to detecting the onset of a low activity state in the subject. 8. The neural modulation system of claim 7, wherein the signal processing portion is configured to: initiate a release period during which no chemical blocking agent control signal is generated after an interval determined relative to an onset of generation of the chemical blocking agent control signal. 9. The neural modulation system of claim 7, wherein the signal processing portion is configured to generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject at a time selected from substantially immediately upon detecting the onset of the low activity state in the subject and at a delay interval after detecting the onset of the low activity state in the subject. 10. The neural modulation system of claim 1, wherein the signal processing portion is configured to: predict an onset of the low activity state; and generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject at least intermittently relative to the predicted onset of the low activity state in the subject. 11. The neural modulation system of claim 10, wherein the signal processing portion is configured to generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject at least intermittently at a time selected from prior to the predicted onset of the low activity state in the subject, substantially simultaneously with the predicted onset of the low activity state in the subject, and subsequent to the predicted onset of the low activity state in the subject. 12. The neural modulation system of claim 1, wherein the signal processing portion is configured to: determine an onset of the higher activity state in the subject; andinitiate a release period during which no chemical blocking agent control signal is generated responsive to detecting the higher activity state in the subject. 13. The neural modulation system of claim 12, wherein the signal processing portion is configured to: initiate the release period at a time selected from substantially immediately upon detection of the onset of the higher activity state in the subject and at a delay interval after detection of an onset of the higher activity state in the subject. 14. The neural modulation system of claim 1, wherein the signal processing portion is configured to: predict the onset of the higher activity state in the subject; andinitiate a release period during which no chemical blocking agent control signal is generated relative to a predicted onset of the higher activity state in the subject. 15. The neural modulation system of claim 14, wherein the signal processing portion is configured to: initiate the release period at a time selected from at an interval prior to the predicted onset of the higher activity state in the subject, substantially simultaneously with the predicted onset of the higher activity state in the subject, and at a delay interval after the predicted onset of the higher activity state in the subject. 16. The neural modulation system of claim 1, wherein the signal processing portion is configured to generate a release stimulus control signal for controlling discontinuation of delivery of the chemical blocking agent when the subject is in a higher activity state. 17. The neural modulation system of claim 16, wherein the signal processing portion is configured to repetitively generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and generate the release stimulus control signal for controlling discontinuation of delivery of the chemical blocking agent when the subject is in the higher activity state. 18. The neural modulation system of claim 17, wherein the signal processing portion is configured to repetitively generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and generate the release stimulus control signal for controlling discontinuation of delivery of the chemical blocking agent when the subject is in the higher activity state cyclically, wherein each cycle includes a blocking period during which the chemical blocking agent sufficient to produce reversible conduction block in the peripheral neural structure of the subject is delivered while the subject is in the low activity state and a release period during which no chemical blocking agent is delivered. 19. The neural modulation system of claim 17, wherein the signal processing portion is configured to repetitively generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and generate the release stimulus control signal for controlling discontinuation of delivery of the chemical blocking agent when the subject is in the higher activity state in alternation according to a pre-set schedule. 20. The neural modulation system of claim 17, wherein the signal processing portion is configured to repetitively generate the chemical blocking agent control signal for driving delivery of the chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and generate the release stimulus control signal for controlling discontinuation of delivery of the chemical blocking agent when the subject is in the higher activity state over a period of time sufficient to produce modulation of at least one of an immune response or an inflammatory response in a region innervated by the peripheral neural structure. 21. The neural modulation system of claim 1, wherein the chemical blocking agent source includes: a primary chemical blocking agent source configured to deliver a primary chemical blocking agent component; anda secondary chemical blocking agent source configured to deliver a secondary chemical blocking agent component;wherein the primary chemical blocking agent component and the secondary chemical blocking agent component act together to reversibly block conduction in the peripheral neural structure, and wherein the signal processing portion is configured to generate a chemical blocking agent control signal including a primary chemical blocking agent control signal for driving delivery of the primary chemical blocking agent component and a secondary chemical blocking agent control signal for driving delivery of the secondary chemical blocking agent component. 22. The neural modulation system of claim 1, wherein the signal processing portion is configured to: determine that producing a reversible conduction block in the peripheral neural structure of the subject while the subject is in the low activity state results in a desired effect in the subject; andgenerate a non-reversible blocking source control signal for driving a non-reversible blocking source to perform an action adapted for producing a non-reversible conduction block in the peripheral neural structure of the subject; andwherein the neural modulation system further comprises the non-reversible blocking source configured to perform the action adapted for producing the non-reversible conduction block in the peripheral neural structure of the subject responsive to the non-reversible blocking source control signal. 23. The neural modulation system of claim 22, wherein the non-reversible blocking source includes at least one of a heat source, a cooling source, an electrical current source, an acoustic energy source, a photon source, a chemical agent source, or a surgical transection mechanism. 24. The neural modulation system of claim 22, wherein the non-reversible blocking source includes a heat source configured to produce thermal ablation of at least a portion of the peripheral neural structure of the subject. 25. The neural modulation system of claim 22, wherein the non-reversible blocking source includes a heat source that includes at least one of a Peltier device, a resistive element, a fluid heat-transfer device, or an exothermic reaction device. 26. The neural modulation system of claim 22, wherein the non-reversible blocking source includes a cooling source that includes at least one of a Peltier device, an endothermic reaction device, or a fluid heat-transfer device. 27. The neural modulation system of claim 1, wherein the chemical blocking agent source includes at least one of an iontophoresis device, an electroporation device, a sonophoresis device, a phonophoresis device, a microneedle array, a MEMS device, a plurality of microreservoirs, a chemical blocking agent in a polymeric matrix, or an infusion pump. 28. The neural modulation system of claim 1, wherein the chemical blocking agent source includes at least one of an electric field source, an electrical current source, a magnetic field source, an electromagnetic transducer, an acoustic energy source, or an ultrasonic acoustic energy source.
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