Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the
Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
대표청구항▼
1. An inhaleable powder composition comprising a plurality of particulate microstructures, the particulate microstructures comprising: (a) a structural matrix comprising phospholipid and calcium, wherein the particulate microstructures comprise greater than about 50% phospholipid;(b) an active agent
1. An inhaleable powder composition comprising a plurality of particulate microstructures, the particulate microstructures comprising: (a) a structural matrix comprising phospholipid and calcium, wherein the particulate microstructures comprise greater than about 50% phospholipid;(b) an active agent;(c) a mean geometric diameter of 1-30 microns;(d) a mean aerodynamic diameter of less than 5 microns; and(e) a bulk density of less than about 0.5 g/cm3. 2. The composition of claim 1 wherein the particulate microstructures are porous and have a mean porosity of 0.5-80%. 3. The composition of claim 2 wherein the particulate microstructures have a mean porosity of 2-40%. 4. The composition of claim 3 wherein the particulate microstructures have a mean pore size of 20-200 nm. 5. The composition of claim 1 wherein the fine particle fraction of the particulate microstructures in the composition is greater than 20% w/w. 6. The composition of claim 5 wherein the fine particle fraction of the particulate microstructures in the composition is from about 30% to 70% w/w. 7. The composition of claim 1 wherein the particulate microstructures comprise a bulk density of less than 0.1 g/cm3. 8. The composition of claim 7 wherein the particulate microstructures comprise a bulk density of less than 0.05 g/cm3. 9. The composition of claim 1 wherein the particulate microstructures comprise perforated microstructures. 10. The composition of claim 1 wherein said particulate microstructures comprise hollow microspheres. 11. The composition of claim 1 wherein the particulate microspheres comprise a shell with a thickness of 0.1-0.5 μm. 12. The composition of claim 1 wherein the particulate microstructures comprise a mean aerodynamic diameter of between 0.5 μm and 5 μm. 13. The composition of claim 1 wherein the particulate microstructures comprise a mean geometric diameter of less than 10 microns. 14. The composition of claim 13 wherein the particulate microstructures comprise mean geometric diameter is less than 5 microns. 15. The composition of claim 1 wherein the phospholipid comprises a gel to liquid crystal transition temperature of greater than 40° C. 16. The composition of claim 1 wherein the phospholipid comprises a zwitterionic phospholipid. 17. The composition of claim 1 wherein the phospholipid comprises at least one of dilauroylphosphatidylcholine, dioleoylphosphatidylcholine, dipalmitoylphosphatidylcholine, disteroylphosphatidylcholine dibehenoylphosphatidylcholine, diarachidoylphosphatidylcholine and combinations thereof. 18. The composition of claim 1 wherein the active agent is a bioactive agent. 19. The composition of claim 18 wherein the bioactive agent comprises at least one of antiallergics, bronchodilators, pulmonary lung surfactants, analgesics, antibiotics, antiinfectives, leukotriene inhibitors or antagonists, antihistamines, antiinflammatories, antineoplastics, anticholinergics, anesthetics. antituberculars, antivirals, fungicides, immunoactive agents, vaccines, immunosuppressive agents, imaging agents, cardiovascular agents, enzymes, steroids, DNA, RNA, viral vectors, antisense agents, proteins, peptides and combinations thereof. 20. The composition of claim 18 wherein the bioactive agent comprises at least one of fentanyl, morphine, lung surfactant, leuprolide, interferon, insulin, budesonide, formoterol, goserelin, and growth hormones. 21. The composition of claim 18 wherein the bioactive agent is an aminoglycoside antibiotic. 22. The composition of claim 18 wherein the bioactive agent is a fungicide. 23. A composition comprising a plurality of particulate microstructures, the particulate microstructures comprising: (a) a structural matrix comprising phospholipid and calcium, the phospholipid comprising a gel to liquid crystal transition temperature of greater than 40° C., wherein greater than about 50% of the particulate microstructures comprise phospholipid;(b) an active agent;(c) a mean geometric diameter of 1-30 microns;(d) a mean aerodynamic diameter of less than 5 microns; and(e) a bulk density of less than about 0.5 g/cm3. 24. The composition of claim 23 wherein the particulate microstructures are porous and have a mean porosity of 0.5-80%. 25. The composition of claim 24 wherein the particulate microstructures have a mean porosity of 2-40%. 26. The composition of claim 24 wherein the particulate microstructures have a mean pore size of 20-200 nm. 27. The composition of claim 23 wherein the fine particle fraction of the particulate microstructures in the composition is greater than 20% w/w. 28. The composition of claim 27 wherein the fine particle fraction of the particulate microstructures in the composition is from about 30% to 70% w/w. 29. The composition of claim 23 wherein the particulate microstructures comprise a bulk density of less than 0.1 g/cm3. 30. The composition of claim 29 wherein the particulate microstructures comprise a bulk density of less than 0.05 g/cm3. 31. The composition of claim 23 wherein the particulate microstructures comprise perforated microstructures. 32. The composition of claim 23 wherein said particulate microstructures comprise hollow microspheres. 33. The composition of claim 23 wherein the particulate microspheres comprise a shell with a thickness of 0.1-0.5 μm. 34. The composition of claim 23 wherein the particulate microstructures comprise a mean aerodynamic diameter of between 0.5 μm and 5 μm. 35. The composition of claim 23 wherein the particulate microstructures comprise a mean geometric diameter of less than 10 microns. 36. The composition of claim 35 wherein the particulate microstructures comprise mean geometric diameter is less than 5 microns. 37. The composition of claim 23 wherein the phospholipid comprises a gel to liquid crystal transition temperature of greater than 40° C. 38. The composition of claim 23 wherein the phospholipid comprises a zwitterionic phospholipid. 39. The composition of claim 23 wherein the phospholipid comprises at least one of dilauroylphosphatidylcholine, dioleoylphosphatidylcholine, dipalmitoylphosphatidylcholine, disteroylphosphatidylcholine dibehenoylphosphatidylcholine, diarachidoylphosphatidylcholine and combinations thereof. 40. The composition of claim 23 wherein the active agent is a bioactive agent. 41. The composition of claim 40 wherein the bioactive agent comprises at least one of antiallergics, bronchodilators, pulmonary lung surfactants, analgesics, antibiotics, antiinfectives, leukotriene inhibitors or antagonists, antihistamines, antiinflammatories, antineoplastics, anticholinergics, anesthetics. antituberculars, antivirals, fungicides, immunoactive agents, vaccines, immunosuppressive agents, imaging agents, cardiovascular agents, enzymes, steroids, DNA, RNA, viral vectors, antisense agents, proteins, peptides and combinations thereof. 42. The composition of claim 40 wherein the bioactive agent comprises at least one of fentanyl, morphine, lung surfactant, leuprolide, interferon, insulin, budesonide, formoterol, goserelin, and growth hormones. 43. The composition of claim 40 wherein the bioactive agent is an aminoglycoside antibiotic. 44. The composition of claim 40 wherein the bioactive agent is a fungicide.
Crystal Ronald G. ; Dalemans Wilfried,BEX ; Perricaudet Michel,FRX ; Stratford-Perricaudet Leslie,FRX ; Pavirani Andrea,FRX, Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung.
Edwards David A. ; Caponetti Giovanni,ITX ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Ben-Jebria Abdell Aziz ; Langer Robert S., Aerodynamically light particles for pulmonary drug delivery.
Edwards David A. ; Caponetti Giovanni,ITX ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Ben-Jebria Abdell Aziz ; Langer Robert S., Aerodynamically light particles for pulmonary drug delivery.
Fu Lu Mou-Ying (Lake Bluff IL) Adjei Akwete L. (Wadsworth IL) Gupta Pramod K. (Gurnee IL), Aerosol drug formulations containing polyglycolyzed glycerides.
Duan Daniel C. (St. Paul MN) Stefely James S. (Woodbury MN) Schultz David W. (Pine Springs MN) Leach Chester L. (Lake Elmo MN), Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid.
Duan Daniel C. ; Stefely James S. ; Schultz David W. ; Leach Chester L., Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid.
Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Aerosol formulations containing P134a and particulate medicaments.
Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Aerosol formulations containing propellant 134a and fluticasone propionate.
Evans Richard M. (Westwood MA) Farr Stephen J. (Llandaf GB7), Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol.
Cherukuri Subraman R. (Towaco NJ) Calabro Frank P. (Budd Lake NJ) Mansukhani Gul (Staten Island NY) Rieger Martin M. (Morris Plains NJ) Elefant Milton (Livingston NJ), Antacid chewing gum.
Livesey Stephen A.,AUX ; del Campo Anthony A. ; Nag Abhijit ; Nichols Ken B. ; Piunno Carmen ; Ross David P., Apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions.
Sekins K. Michael (San Diego CA) Shaffer Thomas H. (Lansdowne PA) Wolfson Marla R. (Wyndmoor PA), Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation.
Bonte Frdric (Boulogne FRX) Dehan Michel (Verrieres le Buisson FRX) Le Ridant Alain (Neuilly sur Seine FRX) Puisieux Francis (Maisons Alfort FRX) Taupin Christiane C. (Orsay FRX), Artificial surfactants, pharmaceutical compositions containing them and use thereof.
Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Canister containing aerosol formulations containing P134a and particulate medicaments.
Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Canister containing aerosol formulations containing P134a and particulate medicaments.
Akehurst Rachel Ann,GB3 ; Taylor Anthony James,GB3 ; Wyatt David Andrew,GB3, Canister containing aerosol formulations containing P134a and particulate medicaments.
Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Canisters containing aerosol formulations containing P134a and fluticasone propionate.
Wang Yu-chang J. (Los Altos CA) Lee William A. (Los Altos CA) Narog Blair (Palo Alto CA), Composition and method for administration of pharmaceutically active substances.
Platz, Robert M.; Patton, John S.; Foster, Linda; Eljamal, Mohammed, Composition for pulmonary administration comprising a drug and a hydrophobic amino acid.
Johnson OluFunmi Lily (Cambridge MA) Ganmukhi Medha M. (Wexford PA) Bernstein Howard (Cambridge MA) Auer Henry (Belmont MA) Khan M. Amin (Dowington PA), Composition for sustained release of human growth hormone.
Platz, Robert M.; Patton, John S.; Foster, Linda; Eljamal, Mohammed, Compositions and methods for the pulmonary delivery of aerosolized macromolecules.
Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Beam John E. (Norwalk CT) Mackay Donald A. M. (Pleasantville NY), Compressed chewable antacid tablet and method for forming same.
Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Vink Walter (Purdys Station NY), Compressed chewable antacid tablet and method for forming same.
Trevino Leo A. (San Diego CA) Dellamary Luis A. (San Marcos CA) Tarara Thomas E. (San Diego CA) Weers Jeffry G. (San Diego CA) Ranney Helen M. (La Jolla CA), Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents.
Schrder Ulf (Fagottgrnden 11 B S-223 68 Lund SEX), Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use the.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
Shishov Nikolai M. (Moscow SUX) Zelenetsky Vladimir E. (Moscow SUX) Demina Nadezhda A. (Moscow SUX) Bondarev Ivan M. (Moscow SUX) Cherny Alexandr N. (Moscow SUX) Moskvitin Valery A. (Belgorod-Dnestro, Device for administering powdered substances.
Platz, Robert M.; Patton, John S.; Foster, Linda; Eljamal, Mohammed, Devices compositions and methods for the pulmonary delivery of aerosolized medicaments.
Platz Robert M. ; Patton John S. ; Foster Linda C. ; Eljamal Mohammed,LBX, Dispersible antibody compositions and methods for their preparation and use.
Platz Robert M. ; Patton John S. ; Foster Linda C. ; Eljamal Mohammed,LBX, Dispersible antibody compositions and methods for their preparation and use.
Illum Lisbeth (Nottingham GBX), Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving mater.
Barger Lee Allen ; Bowyer Terrance George ; Britto Ignatius Loy ; Franklin Michael Leon, Flow-through metered aerosol dispensing apparatus and method of use thereof.
Fuhrman Bradley P. (Buffalo NY) Flaim Stephen F. (San Diego CA) Hernan Lynn J. (Buffalo NY) Nesti Frances D. (Shelburne VT) Papo Michele C. (Buffalo NY) Steinhorn David M. (Eggertsville NY), Fluorocarbons as anti-inflammatory agents.
Byron Peter R. (Richmond) Dalby Richard N. (Richmond VA), Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content.
Byron Peter R. (Richmond VA) Dalby Richard N. (Richmond VA), Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content.
Kaufman Robert J. ; Richard Thomas J. ; Stephens Richard A. ; Goodin Thomas H. ; Allen John S. ; Layton Tony E., Homogeneous water-in-perfluorochemical stable liquid dispersion for administration of a drug to the lung of an animal.
Ducheyne Paul (Rosemont PA) Radin Shulamith (Voorhees NJ) Santos Erick M. (Philadelphia PA), Incorporation of biologically active molecules into bioactive glasses.
Cohen Smadar (Petach-Tickva ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
Doat Bernard J. M. (Angers FRX) Letavernier Jean-Francois J. (Angers FRX) Aubard Gilbert G. (Palaiseau FRX) Llull Jean B. (Morsang sur Orge FRX) Calvet Alain P. (Versailles FRX) Junien Jean-Louis (Pa, Laxative composition based on lactulose and its preparation process.
Cloosterman Aloysius B. M. (Emmerich DEX) Kranenburg Simon V. (Ijssel NLX), Lipid and protein containing material in particulate form and process therefor.
Villax Peter (Lisbon PTX) Peres Rui (Cascais PTX) Treneman William Richard (Cambs GB3) McDerment Iain Grierson (Herts GB3) Bunce Martin (London GB3), Medicament inhaler and method.
Byron Peter R. (Richmond VA) Blondino Frank E. (Richmond VA), Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable.
Johansson Eric T. ; Ritson Carl ; Rubsamen Reid M., Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissue and controlling their r.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their.
Malfroy-Camine Bernard (Arlington MA), Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier perm.
Greenleaf David J. (Loughborough GB3) Purewal Tarlochan S. (Leamington Spa GB3) Jinks Philip A. (Mount Sorrel GB3), Method for preparing medicinal aerosol formulation containing coated medicament.
Colaco Camilo,GBX ; Roser Bruce J.,GBX ; Sen Shevanti,GBX, Method for stabilization of biological substances during drying and subsequent storage and compositions thereof.
Colaco Camilo,GBX ; Roser Bruce J.,GBX ; Sen Shevanti,GBX, Method for stabilization of biological substances during drying and subsequent storage and compositions thereof.
Bachmann Peter A. (Veterinar-Str. 13 8000 Munich 22 DEX) Mayr Anton (Veterinar-Str. 13 8000 Munich 22 DEX), Method of preparing an attenuated transmissible gastroenteritis (TGE) virus strain for use in live vaccines.
Roser Bruce J. (Balsham GB2) Colaco Camilo (Trumpington GB2), Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sug.
Schmitt Heinz J. (Millington NJ) Armstrong Donald (New York NY) Bernard Edward M. (Alandale NJ), Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes.
Lichtenberger Lenard M. (Houston TX 4), Methods and compositions employing unique mixtures of polar and neutral lipids for surfactant replacement therapy.
Platz Robert M. ; Kimura Shigenobu,JPX ; Satoh Yu-ichiro,JPX ; Foster Linda C., Methods and compositions for the dry powder formulation of interferons.
Platz Robert M. ; Kimura Shigenobu,JPX ; Satoh Yu-ichiro,JPX ; Foster Linda C., Methods and compositions for the dry powder formulation of interferons.
Johnson Keith A. (Sunnyvale CA) Gordon Marc S. (Sunnyvale CA) Lyons Shirley W. (Sunnyvale CA), Methods and system for processing dispersible fine powders.
Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Methods of preparing gas and gaseous precursor-filled microspheres.
Alan G. Tunnacliffe GB; David T. Welsh GB; Bruce J. Roser GB; Kamaljit S. Dhaliwal GB; Camilo Colaco GB, Methods of preserving prokaryotic cells and compositions obtained thereby.
Bernstein Howard (Cambridge MA) Straub Julie A. (Winchester MA) Brush Henry T. (Somerville MA) Wing Richard E. (Cambridge MA), Microencapsulated fluorinated gases for use as imaging agents.
Egan Edmund A. ; Holm Bruce A. ; Ferguson William H., Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction.
Bernstein Howard (Cambridge MA) Zhang Yan (Cambridge MA) Khan M. Amin (Downingtown PA) Tracy Mark A. (Arlington MA), Modulated release from biocompatible polymers.
Fassberg Julianne (New York NY) Sequeira Joel A. (New York NY) Chaudry Imtiaz A. (North Caldwell NJ) Kopcha Michael (East Brunswick NJ), Non-chlorofluorocarbon aerosol formulations.
Bot, Adrian I.; Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexev; Schutt, Ernest G.; Dellamary, Luis A., Particulate delivery systems and methods of use.
DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
Edwards David A. ; Caponetti Giovanni ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Langer Robert S. ; Ben-Jebria Abdellaziz, Porous particles for deep lung delivery.
Rubsamen Reid ; Gonda Igor ; Farr Stephen ; Cipolla David, Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of und.
Chen Li J. (Hsin-Ying) Chen Chun N. (Chia-Yi) Lin Shan Y. (Taipei TWX), Preparation method of microdispersed tablet formulation of spray-dried sodium diclofenac enteric-coated microcapsules.
Sutton Andrew D. (Ruddington GB2) Johnson Richard A. (West Bridgford GB2) Senior Peter J. (Near Melbourne GB2) Heath David (The Park GB2), Preparation of diagnostic agents.
Osborne Nicholas,GBX ; Sutton Andrew Derek,GBX ; Johnson Richard Alan,GBX, Preparation of hollow microcapsules by spray-drying an aqueous solution of a wall-forming material and a water-miscible.
Cohan Allan N. (1143 Wright Dr. Huntingdon Valley PA 19006), Process for producing round spherical free flowing blown bead food products of controlled bulk density.
Platz Robert M. (Half Moon Bay CA) Winters Mark A. (Mountain View CA) Pitt Colin G. (Thousand Oaks CA), Pulmonary administration of granulocyte colony stimulating factor.
Benson Bradley J. (170 Cresta Vista Dr. San Francisco CA 94127) Wright JoRae (170 Cresta Vista Dr. San Francisco CA 94127), Pulmonary administration of pharmaceutically active substances.
Bodner Mordechai (San Diego CA) De Polo Nicholas J. (Solana Beach CA) Chang Stephen (Poway CA) Hsu David Chi-Tang (San Diego CA) Respess James G. (San Diego CA), Retroviral delivery of full length factor VIII.
Knight Jack V. (Houston TX) Gilbert Brian E. (Houston TX) Wilson Samuel Z. (Houston TX) Six Howard R. (East Stroudsborg PA) Wyde Philip R. (Houston TX), Small particle aerosol liposome and liposome-drug combinations for medical use.
Roser, Bruce J.; Colaco, Camilo; Jerrow, Mohammed A. Z.; Blair, Julian; Kampinga, Jaap; Wardell, James Lewis; Duffy, John Alistair, Solid delivery systems for controlled release of molecules incorporated therein and methods of making same.
Manning Mark C. ; Randolph Theodore W. ; Shefter Eli ; Falk ; III Richard F., Solubilization of pharmaceutical substances in an organic solvent and preparation of pharmaceutical powders using the s.
Sutton Andrew D.,GBX ; Johnson Richard A.,GBX ; Senior Peter J.,GBX ; Heath David,GBX, Spray-dried microparticles and their use as therapeutic vehicles.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonge S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Goldin Stanley M. (Lexington MA) Katragadda Subbarao (Belmont MA) Hu Lain-Yen (Bedford MA) Reddy N. Laxma (Malden MA) Fischer James B. (Cambridge MA) Knapp Andrew G. (Salem MA) Margolin Lee D. (Belmo, Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for ident.
Wong Sui-Ming (Collegeville PA) Newington Ian M. (Hazlemere GB2) Liversidge Elaine M. (West Chester PA) McIntire Gregory L. (West Chester PA) Pitt Alan R. (Sandridge GBX) Shaw Jack M. (Aberdeen MD), Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions.
Liversidge Gary G. (West Chester PA) Conzentino ; Jr. Philip (West Chester PA) Cundy Kenneth C. (Pottstown PA) Sarpotdar Pramod P. (Malvern PA), Surface modified NSAID nanoparticles.
Liversidge Gary G. (West Chester PA) Cundy Kenneth C. (Pottstown PA) Bishop John F. (Rochester NY) Czekai David A. (Honeoye Falls NY), Surface modified drug nanoparticles.
Andersson Jan (Sodra Sandby SEX) Jagfeldt Hans (Lund SEX) Trofast Eva (Lund SEX) Wetterlin Kjell (Sodra Sandby SEX), System for dispensing pharmaceutically active compounds.
Backstrom Kjell Goran Erik,SEX ; Dahlback Carl Magnus Olof,SEX ; Edman Peter,SEX ; Johansson Ann Charlotte Birgit,SEX, Systemic administration of a therapeutic preparation.
Bckstrm Kjell G. E. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Edman Peter (Bjrred SEX) Johansson Ann C. B. (Lund SEX), Systemic administration of a therapeutic preparation.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic delivery systems related applications.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic drug delivery systems.
Backstrom Kjell Goran Erik,SEX ; Dahlback Carl Magnus Olof,SEX ; Edman Peter,SEX ; Johansson Ann Charlotte Birgit,SEX, Therapeutic preparation for inhalation.
Bckstrm Kjell G. E. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Edman Peter (Bjrred SEX) Johansson Ann C. B. (Lund SEX), Therapeutic preparation for inhalation.
Berger Jacob (Los Altos Hills) Clark Robin D. (Palo Alto) Eglen Richard M. (Mountain View) Smith William L. (Sunnyvale) Weinhardt Klaus K. (San Francisco CA), Tricyclic 5-HT3receptor antagonists.
Schultz Robert K. (Shoreview MN) Quessy Stephen N. (St. Paul MN), Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations.
Vehring, Reinhard; Hartman, Michael Steven; Smith, Adrian Edward; Joshi, Vidya B.; Dwivedi, Sarvajna Kumar, Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems.
Vehring, Reinhard; Hartman, Michael Steven; Smith, Adrian Edward; Joshi, Vidya B.; Dwivedi, Sarvajna Kumar, Compositions for pulmonary delivery of long-acting β2 adrenergic receptor agonists and associated methods and systems.
Vehring, Reinhard; Hartman, Michael Steven; Lechuga-Ballesteros, David; Smith, Adrian Edward; Joshi, Vidya B.; Dwivedi, Sarvajna Jumar, Compositions, methods and propellant-based systems for respiratory delivery of glycopyrrolate and one or more active agents.
Vehring, Reinhard; Hartman, Michael Steven; Lechuga-Ballesteros, David; Smith, Adrian Edward; Joshi, Vidya B.; Dwivedi, Sarvajna Kumar, Compositions, methods and systems for respiratory delivery of two or more active agents.
Vehring, Reinhard; Hartman, Michael Steven; Lechuga-Ballesteros, David; Smith, Adrian Edward; Joshi, Vidya B.; Dwivedi, Sarvajna Kumar, Compositions, methods and systems for respiratory delivery of two or more active agents.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.