[특허]Nanoparticles containing polymeric nucleic acid homologs

[미국특허] Nanoparticles containing polymeric nucleic acid homologs 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/16 C12N-015/11
출원번호	US-0497783 (2002-12-05)
등록번호	US-8178128 (2012-05-15)
국제출원번호	PCT/IL02/00985 (2002-12-05)
§371/§102 date	20041213 (20041213)
국제공개번호	WO03/048298 (2003-06-12)
발명자 / 주소	Golomb, Gershon Sacks, Haigt Najareh, Yousef Fishbein, Elia Chorny, Michael
출원인 / 주소	Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
대리인 / 주소	Pasternak, Dahna S.
인용정보	피인용 횟수 : 1 인용 특허 : 40

초록 ▼

A nanoparticle capable of delivery of an encapsulated molecule into a living cell. The nanoparticle includes an encapsulation media and an isolated nucleic acid homolog sequence. The encapsulation media is primarily polymeric. The nanoparticles release the encapsulated molecule over an extended period of time. Further disclosed are pharmaceutical compositions and articles of manufacture including nanoparticles and methods of preparing and using the nanoparticles.

대표청구항 ▼

1. Nanoparticles comprising: (a) a biodegradable polymer PLGA [poly(DL-lactide-co-glycolide)] of a lactide:glycolide ratio of 50:50 in combination with a cationic or neutral liposomal formulation comprising DOSPA or a 1:1 ratio of DOTAP:DOPE;(b) an isolated, bioactive nucleic acid sequence encapsulated within the PLGA, wherein said nanoparticles are capable of releasing said isolated, bioactive nucleic acid sequence over an extended period of time; and(c) the amino acid-sequence as set forth in SEQ ID NO:25. 2. The nanoparticles of claim 1, wherein said nanoparticles further comprise a salt of a divalent cation. 3. The nanoparticles of claim 2, wherein said divalent cation is calcium. 4. The nanoparticles of claim 1, wherein the amino acid sequence is operative to impart to said nanoparticles a specific affinity for at least one target selected from the group consisting of an LDL receptor and a GAG-binding region of apoB-100. 5. The nanoparticles of claim 1, further including mannitol.

이 특허에 인용된 특허 (40) 인용/피인용 타임라인 분석

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Byrne Guerard W. (Hamden CT) Ruddle Frank H. (New Haven CT), Multiplex gene regulation.
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Sorge Joseph A. (San Diego CA), Mutagenesis testing using transgenic non-human animals carrying test DNA sequences.
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Schwartz Robert J. (Houston TX) DeMayo Franco J. (Houston TX) O\Malley Bert W. (Houston TX), Myogenic vector systems.
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Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Positive-negative selection methods and vectors.
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Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
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이 특허를 인용한 특허 (1) 인용/피인용 타임라인 분석

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A	생활필수품
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[미국특허] Nanoparticles containing polymeric nucleic acid homologs 원문보기