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Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal e

Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.

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1. A method of treating epilepsy in a subject comprising: at least partially implanting a medical electrical lead system in a brain of a subject, wherein the lead system comprises a lead body provided with a proximal end and a distal end and a first lumen extending at least partially therebetween; a

1. A method of treating epilepsy in a subject comprising: at least partially implanting a medical electrical lead system in a brain of a subject, wherein the lead system comprises a lead body provided with a proximal end and a distal end and a first lumen extending at least partially therebetween; at least one electrode in the proximity of the distal end of the lead body; and a reservoir in fluid communication with the first lumen and in the form of a second lumen of the lead body or a protrusion, wherein the protrusion is configured to be refilled whether the protrusion is implanted in the lead body of the subject or external to the body of the subject during use, wherein the reservoir is located at a position removed from the distal end of the lead body and situated under a surface of the subject's head; anddelivering at least one bioactive agent to the brain of the subject through the reservoir so that the at least one bioactive agent moves passively from the reservoir to a region of the brain of the subject. 2. The method of claim 1 wherein the reservoir is located in the proximity of the proximal end of the lead body. 3. The method of claim 1 wherein the reservoir is a protrusion extending from the first lumen. 4. The method of claim 1 wherein the reservoir is a protrusion that surrounds a portion of the lead body. 5. The method of claim 1, further comprising delivering the at least one bioactive agent by allowing the bioactive agent to passively advance from the reservoir through the first lumen of the lead body. 6. The method of claim 1, further comprising delivering the at least one bioactive agent by releasing the at least one bioactive agent from the lead system by at least one of diffusion, elution, or effusion. 7. The method of claim 1, further comprising refilling the reservoir. 8. The method of claim 1 wherein the lead body is provided with at least one conductor disposed therein. 9. The method of claim 1 wherein at least one conductor is wound around the first lumen of the lead body. 10. The method of claim 1 wherein the distal end of the lead body is formed from at least one material that is permeable to the at least one bioactive agent. 11. The method of claim 1 wherein the reservoir is in the form of a second lumen of the lead body. 12. The method of claim 1, further comprising refilling the reservoir with a bioactive agent. 13. The method of claim 1, further comprising delivering the at least one bioactive agent by allowing the bioactive agent to passively advance from the reservoir through the first lumen of the lead body by opening a valve provided in the reservoir. 14. The method of claim 1 wherein the at least one bioactive agent is one that facilitates neurostimulation. 15. The method of claim 14 wherein the at least one bioactive agent is an antiepileptic drug and a bioactive agent that facilitates neurostimulation. 16. The method of claim 15 wherein the at least one bioactive agent is levetiracetam. 17. The method of claim 1 wherein the at least one bioactive agent is selected from the group consisting of acetazolamide, carbamazepine, clonazepam, clorazepate, benzodiazepine derivatives, divalproex, ethosuximide, ethotoin, felbamate, fosphenytoin, gabapentin, lamotrigine, levetiracetam, mephobarbital, methsuximide, oxcarbazepine, phenacemide, phenobarbital, phenytoin, pregabalin, primidone, thiopental, tiagabine, topiramate, trimethadione, valproate, zonisamide, tetrodotoxin, and combinations thereof. 18. The method of claim 1 wherein the at least one bioactive agent comprises a benzodiazepine derivative. 19. The method of claim 1 wherein the at least one bioactive agent is selected from the group consisting of allopregnanolone, ganaxolone, and combinations thereof. 20. The method of claim 1 wherein the at least one bioactive agent is one that facilitates recording of one or more signals from the brain of the subject.