Pharmacologically active agents containing esterified phosphonates and methods for use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-057/00
A01N-057/10
A61K-031/66
C07F-009/02
C07D-279/00
C07D-285/00
C07D-295/00
출원번호
US-0635644
(2009-12-10)
등록번호
US-8193167
(2012-06-05)
발명자
/ 주소
Hostetler, Karl Y.
Wan, W. Brad
출원인 / 주소
The Regents of the University of California
대리인 / 주소
Kilpatrick Townsend & Stockton LLP
인용정보
피인용 횟수 :
7인용 특허 :
100
초록
Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.
대표청구항▼
1. A compound having the following formula: Px—O—R,or a pharmaceutically acceptable derivative thereof, wherein Px is a cyclic cidofovir, O is an oxygen atom, and R is selected from the group consisting of eicosyl, docosyl and tetracosyl. 2. The compound of claim 1, wherein R is eicosyl or docosyl.
1. A compound having the following formula: Px—O—R,or a pharmaceutically acceptable derivative thereof, wherein Px is a cyclic cidofovir, O is an oxygen atom, and R is selected from the group consisting of eicosyl, docosyl and tetracosyl. 2. The compound of claim 1, wherein R is eicosyl or docosyl. 3. The compound of claim 1, wherein the compound is eicosyl cyclic cidofovir. 4. The compound of claim 1, wherein the compound is docosyl cyclic cidofovir. 5. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier. 6. An article of manufacture, comprising packaging material and the compound of claim 1, contained within the packaging material, wherein the compound is effective for treatment of a disease associated with a viral infection and the packaging material includes a label that indicates that the compound is used for treatment of a disease associated with the viral infection, wherein said viral infection is influenza, hepatitis B virus, hepatitis C virus, cytomegalovirus, Varicella zoster virus, Herpes simplex virus type 1, Herpes simplex virus type 2, Herpes virus type 6, Herpes virus type 8, Epstein Barr virus, retrovirus, orthopox virus, ebola virus, adenovirus or papilloma virus. 7. A method for treating a viral infection in a mammal, wherein the method comprises administering to a subject in need thereof an effective amount of the compound of claim 1, wherein the viral infection is caused by influenza, hepatitis B virus, hepatitis C virus, cytomegalovirus, Varicella zoster virus, Herpes simplex virus type 1, Herpes, simplex virus type 2, Herpes virus type 6, Herpes virus type 8, Epstein Barr virus, retrovirus, orthopox virus, ebola virus, adenovirus or papilloma virus. 8. The method according to claim 7, wherein the viral infection is an orthopox viral infection selected from the group consisting of smallpox, cowpox, camelpox, and monkeypox. 9. The method according to claim 7, wherein the viral infection is a herpes viral infection. 10. The method according to claim 7, wherein the viral infection is a hepatitis B or a hepatitis C infection.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (100)
Khorlin Alexandr A. (ulitsa Generala Antonova ; 7 ; korpus 1 ; kv. 131 Moscow SUX) Tarusova Natalya B. (ulitsa Zhivopisnaya ; 50 ; kv. 40 Moscow SUX) Dyatkina Natalya B. (ulitsa Generala Antonova ; 7, 5′phosphonates of 3′-azido-2′,3′dideoxynucleosides.
Arimilli Murty N. ; Cundy Kenneth C. ; Dougherty Joseph P. ; Kim Choung U. ; Oliyai Reza ; Stella Valentino J., Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability.
Arimilli Murty N. ; Cundy Kenneth C. ; Dougherty Joseph P. ; Kim Choung U. ; Oliyai Reza ; Stella Valentino J., Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability.
Arimilli Murty N. ; Cundy Kenneth C. ; Dougherty Joseph P. ; Kim Choung U. ; Oliyai Reza ; Stella Valentino J., Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability.
Arimilli Murty N. ; Cundy Kenneth C. ; Dougherty Joseph P. ; Kim Choung U. ; Oliyai Reza ; Stella Valentino J., Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability.
Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
Breuer Eli (Jerusalem ILX) Golomb Gershon (Efrat ILX), Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism.
Yatvin Milton B. ; Stowell Michael H. B. ; Gallicchio Vincent S. ; Meredith Michael J., Covalent microparticle-drug conjugates for biological targeting.
Pearson Robert E. (Durham NC) Dickson Julie A. (Raleigh NC) Hamilton Paul T. (Cary NC) Little Michael C. (Raleigh NC) Beyer ; Jr. Wayne F. (Bahama NC), DNA polymerase III b
상세보기
Fujii Kimihiro,JPX ; Tanaka Kazuo,JPX ; Ikawa Kazuya,JPX ; Ikeura Yasuhiro,JPX ; Yamasoto Shinji,JPX, Dermatological patch and process for producing thereof.
Naumann Christoph (Niedernhausen DEX) Lang Hans-Jochen (Hofheim/Taunus DEX) Sandow Jrgen (Glashtten DEX) Moura Anne-Marie (Paris FRX), Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use.
Calanchi Massimo,ITX ; Zema Marco,ITX ; Brunetti Gabriele,ITX ; Giorgetti Enzo,ITX, Method for targeted and controlled release of drugs in the intestinal tract and more particularly in the colon.
Hostetler Karl Y. (Del Mar CA) Kumar Raj (San Diego CA), Method of converting a drug to an orally available form by covalently bonding a lipid to the drug.
Hanhijarvi Hannu (Turku FIX) Nupponen Heikki (Kangasala FIX) Vepslinen Jouko (Tampere FIX) Pohjala Esko (Tampere FIX), Methylenebisphosphonic acid derivatives.
Holy Antonin (HornPocernice CSX) Rosenberg Ivan (Praha CSX) De Clercq Erik D. A. (Leuven BEX), N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiv.
Buhr Chris (Daly City CA) Matteucci Mark (Burlingame CA) Bischofberger Norbert W. (San Carlos CA) Froehler Brian (Belmont CA), Nucleoside 5′-methylene phosphonates.
Bischofberger Norbert (San Carlos CA) Jones Robert J. (Millbrae CA) Arimilli Murty (Fremont CA) Lin Kuei-Ying (Fremont CA) Louie Michael (Burlingame CA) McGee Lawrence R. (Pacifica CA) Prisbe Ernest , Nucleotide analogs.
Venkateshwaran Srinivasan ; Fikstad David ; Ebert Charles D., Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents.
Hostetler Karl Y. (Del Mar CA) Sridhar Nagarajan C. (Simi Valley CA), Prodrugs for oral administration containing taxol or substituted taxol covalently bound to a phospholipid.
Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Targeted gas and gaseous precursor-filled liposomes.
Friend David R. ; Ng Steve ; Sarabia Rafael E. ; Weber Thomas P. ; Geoffroy Jean-Marie, Taste-masked microcapsule compositions and methods of manufacture.
Kaas Susan Mary ; Ebetino Frank Hallock ; Francis Marion David, Thio-substituted, Nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions, and methods of t.
Norris James ; Clawson Gary ; Westwater Caroline ; Schofield David ; Schmidt Michael ; Hoel Brian ; Dolan Joseph ; Pan Wei-Hua, Tissue-specific and pathogen-specific toxic agents and ribozymes.
Schwender Charles (Califon NJ) Demarest Keith (Flemington NJ) Wustrow David (Ann Arbor MI), Trifluoromethylbenzylphosphonates useful in treating osteoporosis.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.