[특허]System, method, and computer software product for genotype determination using probe array data

[미국특허] System, method, and computer software product for genotype determination using probe array data 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G06F-019/00 G06F-019/18
출원번호	US-0123463 (2008-05-19)
등록번호	US-8200440 (2012-06-12)
발명자 / 주소	Hubbell, Earl A. Cawley, Simon
출원인 / 주소	Affymetrix, Inc.
대리인 / 주소	Wells, Sandra E.
인용정보	피인용 횟수 : 3 인용 특허 : 126

초록 ▼

An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate.

대표청구항 ▼

1. A method for determining the genotype of a plurality of nucleic acid samples at a plurality of SNPs, comprising: (a) hybridizing each nucleic acid sample in said plurality of nucleic acid samples to an array of allele specific probes to obtain a plurality of raw probe intensity measurements;(b) normalizing said raw probe intensity measurements to obtain normalized probe intensities;(c) summarizing the normalized probe intensities to obtain an allele signal estimate for each allele of each SNP in each nucleic acid sample, wherein the allele signal estimate for each allele of each SNP in each nucleic acid sample comprises a first value SA and a second value SB where SA is the summary value for a first allele of the SNP and SB is the summary value for a second allele of the SNP;(d) transforming said allele signal estimates in clustering space in one-dimension to obtain a transformed allele signal estimate for each SNP in each nucleic acid sample using the following equation: transformed allele signal estimate =asinh(K(SA−SB)/(SA+SB))/asinh(K), where K is a tuning constant;(e) obtaining a prior distribution of genotype cluster characteristics;(f) evaluating all possible assignments of the transformed allele signal estimates to the genotype clusters of the prior distribution;(g) calculating an optimal assignment from the possible assignments of step (f) for each transformed allele signal estimate, to one or more genotype clusters using a Gaussian cluster model;(h) updating the prior distribution with optimal assignments calculated in (g) to obtain a posterior distribution of genotype cluster characteristics for each SNP; and(i) using the posterior distribution of genotype cluster characteristics for each SNP to make genotype calls for that SNP in each nucleic acid sample. 2. The method of claim 1 wherein the array comprises more than 1 million different sequence probes and wherein each probe is perfectly complementary to an allele of a SNP that has a minor allele frequency of at least 2% in a population. 3. The method of claim 1 further comprising obtaining a confidence value for each of the genotype calls. 4. The method of claim 1 wherein the step of normalizing said raw probe intensity measurements comprises a quantile normalization step, a log-scale transformation and a median polish step. 5. The method of claim 1 wherein K is 2. 6. The method of claim 1 wherein K is 1 to 4. 7. The method of claim 1 wherein the prior distribution of genotype cluster characteristics is a generic prior derived from a plurality of different SNPs. 8. The method of claim 1 wherein the prior distribution of genotype cluster characteristics is a specific prior for each SNP that has been derived using data for that SNP in a plurality of samples. 9. The method of claim 1 wherein there are three possible genotype clusters including in the prior distribution: a first cluster of samples that are homozygous for the first allele, a second cluster of samples that are homozygous for the second allele and a third cluster of samples that are heterozygous and wherein the third cluster is between the first cluster and the second cluster. 10. The method of claim 1 wherein the posterior distribution of genotype cluster characteristics for each SNP comprises a cluster center for each of three possible genotypes, AA, AB and BB, and covariance matrices for each of the three possible genotypes. 11. The method of claim 10 wherein the genotype call is made by obtaining relative probabilities p(AA), p(AB) and p(BB) from the cluster centers and covariance matrices and calling the genotype with the highest probability for each SNP. 12. The method of claim 10 wherein an ordered relationship between the centers of the genotype clusters is required during calculating step (g).

이 특허에 인용된 특허 (126) 인용/피인용 타임라인 분석

Albertson, Donna G.; Pinkel, Daniel; Collins, Colin Conrad; Gray, Joe W., Amplicon in the 20q13 region of human chromosome 20 and uses thereof.
상세보기
Gray Joe W. ; Collins Colin ; Pinkel Daniel ; Kallioniemi Olli-Pekka,FIX ; Tanner Minna M.,FIX, Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer.
상세보기
Maureen T. Cronin ; Edward L. Sheldon ; Charles G. Miyada ; Earl A. Hubbell ; Mark Chee ; Stephen P. A. Fodor ; Xiaohua C. Huang ; Robert J. Lipshutz ; Peter E. Lobban ; MacDonald S. Morris, Analysis of genetic polymorphisms and gene copy number.
상세보기
Dower William J. ; Fodor Stephen P. A., Analysis of surface immobilized polymers utilizing microfluorescence detection.
상세보기
Cronin Maureen T. ; Miyada Charles Garrett ; Hubbell Earl A. ; Chee Mark ; Fodor Stephen P. A. ; Huang Xiaohua C. ; Lipshutz Robert J. ; Lobban Peter E. ; Morris Macdonald S. ; Sheldon Edward L., Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis.
상세보기
Chee Mark ; Cronin Maureen T. ; Fodor Stephen P. A. ; Huang Xiaohua X. ; Hubbell Earl A. ; Lipshutz Robert J. ; Lobban Peter E. ; Morris MacDonald S. ; Sheldon Edward L., Arrays of nucleic acid probes on biological chips.
상세보기
Aldwin Lois (San Mateo CA) Madden Mark (Davis CA) Stemmer Willem P. C. (Los Gatos CA), Association peptides.
상세보기
Marta Blumenfeld FR; Lydie Bougueleret FR; Ilya Chumakov FR; Annick Cohen FR, Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism.
상세보기
Colin Collins, Blood-based assays for breast cancer.
상세보기
Gingeras Thomas R. ; Mack David ; Chee Mark S. ; Berno Anthony J. ; Stryer Lubert ; Ghandour Ghassan ; Wang Ching, Chip-based species identification and phenotypic characterization of microorganisms.
상세보기
Jean I. Montagu, Cleaning deposit devices that form microarrays and the like.
상세보기
Winkler James L. ; Fodor Stephen P. A. ; Buchko Christopher J. ; Ross Debra A. ; Aldwin Lois ; Modlin Douglas N., Combinatorial kit for polymer synthesis.
상세보기
Winkler James L. ; Fodor Stephen P. A. ; Buchko Christopher J. ; Ross Debra A. ; Aldwin Lois ; Modlin Douglas N., Combinatorial strategies for polymer synthesis.
상세보기
Pinkel Daniel ; Gray Joe W. ; Kallioniemi Anne,FIX ; Kallioniemi Olli-Pekka,FIX ; Waldman Frederick ; Sakamoto Masaru,JPX, Comparative Genomic Hybridization (CGH).
상세보기
Pinkel Daniel ; Albertson Donna,GBX ; Gray Joe W., Comparative fluorescence hybridization to nucleic acid arrays.
상세보기
Pinkel, Daniel; Albertson, Donna; Gray, Joe W., Comparative fluorescence hybridization to nucleic acid arrays.
상세보기
Joe Gray ; Dan Pinkel ; Donna Albertson ; Colin Collins ; Russell Baldocchi, Comparative fluorescence hybridization to oligonucleotide microarrays.
상세보기
Pinkel Daniel ; Gray Joe W. ; Kallioniemi Anne,FIX ; Kallioniemi Olli-Pekka,FIX ; Waldman Frederic, Comparative genomic hybridization.
상세보기
Pinkel Daniel ; Gray Joe W. ; Kallioniemi Anne,FIX ; Kallioniemi Olli-Pekka,FIX ; Waldman Frederic, Comparative genomic hybridization.
상세보기
Daniel Pinkel ; Joe W. Gray ; Anne Kallioniemi ; Ollie-Pekka Kallioniemi ; Frederic Waldman ; Masaru Sakamoto JP, Comparative genomic hybridization (CGH).
상세보기
Pinkel Daniel (Walnut Creek CA) Gray Joe W. (San Francisco CA) Kallioniemi Anne (Tampere FIX) Kallioniemi Olli-Pekka (Tampere FIX) Waldman Frederic (San Francisco CA), Comparative genomic hybridization (CGH).
상세보기
Pinkel Daniel ; Gray Joe W. ; Kallioniemi Anne,FIX ; Kallioniemi Olli-Pekka,FIX ; Waldman Frederic ; Sakamoto Masaru,JPX, Comparative genomic hybridization (CGH).
상세보기
Pinkel Daniel ; Gray Joe W. ; Kallioniemi Anne,FIX ; Kallioniemi Olli-Pekka,FIX ; Waldman Frederic ; Sakamoto Masaru,JPX, Comparative genomic hybridization (CGH).
상세보기
Shoulian Dong ; Robert J. Lipshutz ; David J. Lockhart, Complexity management and analysis of genomic DNA.
상세보기
Su, Xing, Complexity management of genomic DNA.
상세보기
Wang, Eugene; Webster, Teresa, Computer software for genotyping analysis using pattern recognition.
상세보기
Friend Stephen H. ; Stoughton Roland, Computer system and method for determining a number of primary targets of a drug.
상세보기
Hubbell Earl A. (Mt. View CA) Lipshutz Robert J. (Palo Alto CA) Morris Macdonald S. (San Jose CA) Winkler James L. (Palo Alto CA), Computer-aided engineering system for design of sequence arrays and lithographic masks.
상세보기
Hubbell Earl A. (Mt. View CA) Morris MacDonald S. (San Jose CA) Winkler James L. (Palo Alto CA), Computer-aided engineering system for design of sequence arrays and lithographic masks.
상세보기
Hubbell Earl A. ; Morris MacDonald S. ; Winkler James L., Computer-aided engineering system for design of sequence arrays and lithographic masks.
상세보기
Chee Mark S., Computer-aided visualization and analysis system for sequence evaluation.
상세보기
Chee Mark S., Computer-aided visualization and analysis system for sequence evaluation.
상세보기
Lincoln Steve E. ; Klingler Tod M. ; Au-Young Janice ; Tang Y. Tom ; Goold Richard D. ; Akerblom Ingrid E. ; Seilhamer Jeffrey J. ; Hawkins Phillip R. ; Murry Lynn E. ; Delegeane Angelo M. ; Levine W, Database for storage and analysis of full-length sequences.
상세보기
Overbeck James W. ; Flowers Peter T. ; Montagu Jean I. ; Mace Myles L. ; Honkanen Peter, Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays.
상세보기
Sundberg Steven A. (San Francisco CA) Fujimoto David (Mountain View CA), Derivatization of solid supports and methods for oligomer synthesis.
상세보기
Dale James Langham,AUX ; Timms Peter,AUX ; Walsh Terence Patrick,AUX, Detection of a nucleic acid sequence or a change therein.
상세보기
Stokke Trond (San Francisco CA) Pinkel Daniel (Walnut Creek CA) Gray Joe W. (San Francisco CA), Detection of amplified or deleted chromosomal regions.
상세보기
Stokke Trond (San Fransisco CA) Pinkel Daniel (Walnut Creek CA) Gray Joe W. (San Fransisco CA), Detection of amplified or deleted chromosomal regions.
상세보기
Bastian Boris ; Pinkel Daniel, Detection of chromosome copy number changes to distinguish melanocytic nevi from malignant melanoma.
상세보기
Boris Bastian ; Daniel Pinkel, Detection of chromosome copy number changes to distinguish melanocytic nevi from malignant melanoma.
상세보기
Pauletti Giovanni E. ; Slamon Dennis J., Detection of copy number changes in colon cancer.
상세보기
Boris Bastian ; Daniel Pinkel, Detection of premalignant melanocytes.
상세보기
Duff Gordon W.,GBX ; Cox Angela,GBX ; Camp Nicola Jane ; di Giovine Francesco S.,GBX, Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype.
상세보기
Oliner Jonathan ; Truong Vivi ; Haber Daniel ; Lee Sean, Downstream genes of tumor suppressor WT1.
상세보기
Lockhart David J. ; Brown Eugene L. ; Wong Gordon G. ; Chee Mark S. ; Gingeras Thomas R., Expression monitoring by hybridization to high density oligonucleotide arrays.
상세보기
Lockhart David J. ; Warrington Janet A. ; Nair Archana, Expression profiles in adult and fetal organs.
상세보기
Su, Hongsheng; Shao, Zhongqi; Tkalec, Ana Lydia; Blain, Francoise; Zimmerman, Joseph, Flavobacterium heparinum expression system.
상세보기
McGall Glenn, Functionalized silicon compounds and methods for their synthesis and use.
상세보기
Laleh Shayesteh ; Joe W. Gray, Genetic alterations associated with cancer.
상세보기
Shayesteh Laleh ; Gray Joe W., Genetic alterations associated with cancer.
상세보기
Ronald H. Jensen ; Michael L. Cher, Genetic alterations associated with prostate cancer.
상세보기
Fodor Stephen P. A. ; Lipshutz Robert J. ; Huang Xiaohua, Hybridization and sequencing of nucleic acids using base pair mismatches.
상세보기
Cronin Maureen T. ; Miyada Charles Garrett ; Trulson Mark ; Gingeras Thomas R. ; McGall Glenn ; Robinson Claire ; Oval Michelle, Hybridization assays on oligonucleotide arrays.
상세보기
Holmes Christopher P. (Sunnyvale CA), Immobilized molecular synthesis of systematically substituted compounds.
상세보기
Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of an array of polymers.
상세보기
Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof.
상세보기
Stern David (Mt. View CA) Fiekowsky Peter (Los Altos CA), Method and apparatus for detection of fluorescently labeled materials.
상세보기
Stern David ; Fiekowsky Peter, Method and apparatus for detection of fluorescently labeled materials.
상세보기
Trulson Mark (Santa Clara CA) Stern David (Mountain View CA) Fiekowsky Peter (Los Altos CA) Rava Richard (Palo Alto CA) Walton Ian (Menlo Park CA) Fodor Stephen P. A. (Palo Alto CA), Method and apparatus for imaging a sample on a device.
상세보기
Trulson Mark ; Stern David ; Fiekowsky Peter ; Rava Richard ; Walton Ian ; Fodor Stephen P. A., Method and apparatus for imaging a sample on a device.
상세보기
Trulson Mark ; Stern David ; Fiekowsky Peter ; Rava Richard ; Walton Ian ; Fodor Stephen P. A., Method and apparatus for imaging a sample on a device.
상세보기
Fodor Stephen P. A. (Palo Alto CA) Mazzola Laura T. (Redwood City CA), Method and apparatus for measuring binding affinity.
상세보기
Bassett, Jr., Douglas; Buskirk, Stewart; Bondarenko, Andrey, Method and system for analyzing biological response signal data.
상세보기
Douglas Bassett, Jr. ; Stewart Buskirk ; Andrey Bondarenko, Method and system for analyzing biological response signal data.
상세보기
Balaban David J. ; Hubbell Earl A. ; Mittmann Michael P. ; Cheung Gloria ; Dai Josie, Method and system for providing a probe array chip design database.
상세보기
Fodor Stephen P. A. ; Solas Dennis W. ; Dower William J., Method for comparing copy number of nucleic acid sequences.
상세보기
Thomas Lorch DE; Andreas Plesch DE; Jorma Isola FI, Method for comparing the number of replications of nucleic acid sequences.
상세보기
Fodor Stephen P. A. ; Lipshutz Robert J. ; Huang Xiaohua, Method of Identifying a Base in a Nucleic Acid.
상세보기
Dean, Frank B.; Lasken, Roger S., Method of amplifying whole genomes without subjecting the genome to denaturing conditions.
상세보기
Gray Joe W. ; Pinkel Daniel ; Tkachuk Douglas, Method of detecting genetic translocations identified with chromosomal abnormalities.
상세보기
Fodor Stephen P. A. ; Solas Dennis W. ; Dower William J., Method of detecting nucleic acids.
상세보기
Fodor Stephen P.A. ; Solas Dennis W. ; Dower William J., Method of detecting nucleic acids.
상세보기
Warthoe Peter Rolf,DKX, Method to clone mRNAs.
상세보기
Mark Chee, Method to detect gene polymorphisms and monitor allelic expression employing a probe array.
상세보기
Kaushikkar,Shantanu; Webster,Teresa; Mei,Rui; McAllister,Linda, Method, system, and computer software for the presentation and storage of analysis results.
상세보기
Joe W. Gray ; Daniel Pinkel, Methods and compositions for chromosome 21-specific staining.
상세보기
Gray, Joe W.; Pinkel, Daniel, Methods and compositions for chromosome-specific staining.
상세보기
Jean-Baptiste Dumas Milne Edwards FR; Aymeric Duclert FR; Lydie Bougueleret CH; Catherine Clusel FR, Methods and compositions for inhibiting neoplastic cell growth.
상세보기
Matsuzaki Hajime ; Murphy Eric A., Methods and compositions for multiplex amplification of nucleic acids.
상세보기
Gray Joe W. (Livermore CA) Pinkel Daniel (Walnut Creek CA), Methods for chromosome-specific staining.
상세보기
Matsuzaki, Hajime; Mei, Rui, Methods for genotyping polymorphisms in humans.
상세보기
Huang, Jing; Jones, Keith W., Methods for high throughput genotyping.
상세보기
Huang, Jing; Jones, Keith W.; Shapero, Michael H., Methods for identifying DNA copy number changes.
상세보기
Huang,Jing; Jones,Keith W; Shapero,Michael H., Methods for identifying DNA copy number changes.
상세보기
Fodor Stephen P. A. ; Solas Dennis W. ; Dower William J., Methods for nucleic acid analysis.
상세보기
Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Methods for screening factorial chemical libraries.
상세보기
Lapidus Stanley N. ; Shuber Anthony P., Methods for the detection of loss of heterozygosity.
상세보기
Montagu Jean I., Moving magnet scanner.
상세보기
David J. Lockhart ; Mark Chee ; Kevin Gunderson ; Lai Chaoqiang ; Lisa Wodicka ; Maureen T. Cronin ; Danny Lee ; Huu M. Tran ; Hajime Matsuzaki, Nucleic acid analysis techniques.
상세보기
Fodor Stephen P. A. ; Stryer Lubert ; Read J. Leighton ; Pirrung Michael C., Nucleotides and analogs having photoremoveable protecting groups.
상세보기
Matson Robert S. ; Coassin Peter J. ; Rampal Jang B. ; Caskey Charles Thomas, Oligonucleotide repeat arrays.
상세보기
Levine Arnold J. ; Murphy Maureen Elizabeth ; Mack David H. ; Gish Kurt Carlyle ; Tom Edward Yat Wah, P53-regulated genes.
상세보기
McGall Glenn H. ; Nam Ngo Q. ; Rava Richard P., Photocleavable protecting groups and methods for their use.
상세보기
Fodor Stephen P. A. ; Holmes Christopher P. ; Solas Dennis W., Photolabile nucleoside protecting groups.
상세보기
Holmes Christopher P. (521 Pine Ave. Sunnyvale CA 94086), Polymer reversal on solid surfaces.
상세보기
Holmes Christopher P. (Sunnyvale CA), Polymer reversal on solid surfaces.
상세보기
Lipshutz Robert J. ; Sapolsky Ronald ; Ghandour Ghassan, Polymorphism detection.
상세보기
Sapolsky Ronald J. ; Lipshutz Robert J., Polymorphism detection.
상세보기
Berno Anthony J., Polymorphism detection utilizing clustering analysis.
상세보기
Berno, Anthony J., Polymorphism detection utilizing clustering analysis.
상세보기
Gray Patrick W. ; Schweickart Vicki L. ; Raport Carol J., Polynucleotides encoding chemokine receptor 88C.
상세보기
Montagu Jean I. ; Honkanen Peter ; Weiner Nathan K., Position sensing with variable capacitance transducers.
상세보기
Pease R. Fabian ; McGall Glenn ; Goldberg Martin J. ; Rava Richard P. ; Fodor Stephen P. A. ; Goss Virginia ; Stryer Lubert ; Winkler James L., Printing oligonucleotide arrays using deprotection agents solely in the vapor phase.
상세보기
Hacia Joseph G. ; Chee Mark S. ; Collins Francis S., Probe-based analysis of heterozygous mutations using two-color labelling.
상세보기
Jay M. Short ; Eric J. Mathur, Production and use of normalized DNA libraries.
상세보기
Ginzinger David G. ; Godfrey Tony E. ; Jensen Ronald H. ; Gray Joe W., Quantitative PCR method to enumerate DNA copy number.
상세보기
Weier Heinz-Ulrich G. (Tracy CA) Gray Joe W. (San Francisco CA), Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using.
상세보기
Fiekowsky Peter ; Bartell Dan M., Scanned image alignment systems and methods.
상세보기
Dower William J. (Menlo Park CA) Fodor Stephen P. A. (Palo Alto CA), Sequencing of surface immobilized polymers utilizing microflourescence detection.
상세보기
Rothschild, Michael; Misinai, Tsvi, Sharing live data with a non cooperative DBMS.
상세보기
Pirrung Michael C. ; Read J. Leighton ; Fodor Stephen P. A. ; Stryer Lubert, Signal detection methods and apparatus.
상세보기
Barrett Ronald W. (Sunnyvale CA) Pirrung Michael C. (Durham NC) Stryer Lubert (Stanford CA) Holmes Christopher P. (Sunnyvale CA) Sundberg Steven A. (San Francisco CA), Spatially-addressable immobilization of anti-ligands on surfaces.
상세보기
Barrett Ronald W. (Sunnyvale CA) Pirrung Michael C. (Durham NC) Stryer Lubert (Stanford CA) Holmes Christopher P. (Sunnyvale CA) Sundberg Steven A. (San Francisco CA), Spatially-addressable immobilization of anti-ligands on surfaces.
상세보기
Barrett Ronald W. (Sunnyvale CA) Pirrung Michael C. (Durham NC) Stryer Lubert (Stanford CA) Holmes Christopher P. (Sunnyvale CA) Sundberg Steven A. (San Francisco CA), Spatially-addressable immobilization of anti-ligands on surfaces.
상세보기
McGall Glenn H. (Mountain View CA) Fodor Stephen P. A. (Palo Alto CA) Sheldon Edward L. (Menlo Park CA), Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces.
상세보기
Goldberg Martin ; Diggelman Martin,CHX ; Hubbell Earl ; McGall Glenn ; Ngo Nam Quoc ; Morris Macdonald ; Yamamoto Mel ; Tan Jennifer ; Rava Richard P., Substrate preparation process.
상세보기
Liu,Wei min; Di,Xiaojun, System and computer software products for comparative gene expression analysis.
상세보기
Timothy J. Maslyn ; Srikar D. Rao ; Benjamin G. Cocks ; Rachel J. Cheng ; Timothy M. Engler ; James R. Kerr ; Steven M. Lassagne ; Jeffrey J. Seilhamer, System and method for generating, analyzing and storing normalized expression datasets from raw expression datasets derived from microarray includes nucleic acid probe sequences.
상세보기
Mei,Rui; Webster,Teresa, System, method, and computer software for genotyping analysis and identification of allelic imbalance.
상세보기
Mei,Rui; Webster,Teresa, System, method, and computer software for genotyping analysis and identification of allelic imbalance.
상세보기
Stern David, Systems and methods for detection of labeled materials.
상세보기
Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA), Very large scale immobilized polymer synthesis.
상세보기
Winkler James L. (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Buchko Christopher J. (Palo Alto CA) Ross Debra A. (Fremont CA) Aldwin Lois (San Mateo CA), Very large scale immobilized polymer synthesis using mechanically directed flow paths.
상세보기
Overbeck James W., Wide field of view and high speed scanning microscopy.
상세보기
Overbeck James W., Wide field of view and high speed scanning microscopy.
상세보기
Gray Joe W. ; Weier Heinz-Ulrich, Y chromosome specific nucleic acid probe and method for determining the Y chromosome in situ.
상세보기

이 특허를 인용한 특허 (3) 인용/피인용 타임라인 분석

Janaway, Gordon A.; Chan, Evelyn Wing-Sim, Visualization tool for qPCR genotyping data.
상세보기
Janaway, Gordon A.; Chan, Evelyn Wing-Sim, Visualization tool for qPCR genotyping data.
상세보기
Janaway, Gordon A.; Chan, Evelyn Wing-Sim, Visualization tool for qPCR genotyping data.
상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 특허

해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[미국특허] System, method, and computer software product for genotype determination using probe array data 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (126) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (3) 인용/피인용 타임라인 분석

활용도 분석정보

활용도 Top5 특허

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[미국특허] System, method, and computer software product for genotype determination using probe array data 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (126) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (3) 인용/피인용 타임라인 분석

활용도 분석정보

활용도 Top5 특허 더보기

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 특허