Clay-based hemostatic agents and devices for the delivery thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/14
A61L-015/16
A61K-009/14
A61F-013/00
출원번호
US-0611830
(2009-11-03)
등록번호
US-8202532
(2012-06-19)
발명자
/ 주소
Huey, Raymond J.
Lo, Denny
Burns, Daniel J.
Basadonna, Giacomo
Hursey, Francis X.
출원인 / 주소
Z-Medica Corporation
대리인 / 주소
Knobbe Martens Olson & Bear, LLP
인용정보
피인용 횟수 :
18인용 특허 :
76
초록▼
Disclosed are device for promoting the clotting of blood comprising a clay material and a release agent. In some embodiments, the clay material is disposed within a substrate and the release agent is disposed within a mesh. The release agent can be configured to make direct contact with a bleeding w
Disclosed are device for promoting the clotting of blood comprising a clay material and a release agent. In some embodiments, the clay material is disposed within a substrate and the release agent is disposed within a mesh. The release agent can be configured to make direct contact with a bleeding wound when the device is in particle form and the clay material can promote hemostasis.
대표청구항▼
1. A hemostatic device, comprising: a clay material;a release agent disposed on a discontinuous surface of the device, the release agent being configured to make direct contact with a bleeding wound or a region of a patient near a bleeding wound when the device is applied to the wound; andwherein th
1. A hemostatic device, comprising: a clay material;a release agent disposed on a discontinuous surface of the device, the release agent being configured to make direct contact with a bleeding wound or a region of a patient near a bleeding wound when the device is applied to the wound; andwherein the device is configured to allow at least a portion of the clay material to come into contact with blood that has passed through the discontinuous surface. 2. The hemostatic agent of claim 1, wherein the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, diatomaceous earth, and combinations of the foregoing materials. 3. The hemostatic agent of claim 1, where the release agent is selected from the group consisting of polyvinyl alcohol, silicone, and gelatinized starch. 4. A device capable of providing a hemostatic effect on a bleeding wound, the device comprising: a gauze substrate;a release agent disposed on the gauze substrate, composed of a different material from the gauze substrate; anda clay material disposed on the gauze substrate;wherein the device is configured to allow at least a portion of each of the clay material and the release agent to make direct contact with blood when the device is positioned on a bleeding wound. 5. The device of claim 4, wherein the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, diatomaceous earth, and combinations of the foregoing materials. 6. The device of claim 4, wherein the gauze substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, oxidized cellulose, rayon, polyester, silk, wool, plastic and combinations of the foregoing. 7. The device of claim 4, wherein the gauze substrate is flexible to allow the gauze substrate to form to a shape of the bleeding wound and to retrain a shape of the bleeding wound. 8. The device of claim 4, where the release agent is selected from the group consisting of polyvinyl alcohol, silicone, and gelatinized starch. 9. The device of claim 4, further comprising a binder to adhere the clay material to the gauze substrate. 10. The device of claim 9, wherein the binder is selected from the group consisting of chitosan, cellulose, calcium alginate, and polyvinyl alcohol. 11. A device for promoting hemostasis comprising: a gauze substrate;a clay material dispersed on the gauze surface; anda release agent, composed of a different material from the gauze substrate, the release agent being configured to make direct contact with a bleeding wound and the release agent being dispersed on the second gauze surface;wherein the device is configured to allow at least a portion of the clay material to come into contact with blood that has passed through the release agent. 12. The device of claim 11, where the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, diatomaceous earth, and combinations of the foregoing materials. 13. A bandage applicable to a bleeding wound, the bandage comprising: a substrate;a clay material attached to the substrate;a mesh defined by a plurality of members arranged to define openings, the openings being dimensioned to accommodate the flow of blood therethrough; anda release agent composed of a different material from the substrate, the release agent being attached to the mesh. 14. The bandage of claim 13, where the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, diatomaceous earth, and combinations of the foregoing materials. 15. The bandage of claim 13, wherein the substrate is fabricated from a material selected from the group consisting of cotton, rayon/polyester cellulose blends, cellulose, paper, silk, wool, plastic, and combinations of the foregoing. 16. A device for promoting hemostasis, comprising: a hemostatic material in particle form;a release agent positioned on the device so as to make direct contact with a bleeding wound when the device is applied to a wound;a receptacle for retaining the hemostatic material and the release agent therein, at least a portion of the receptacle being defined by a mesh having openings therein; andwherein the device is configured to allow at least a portion of the hemostatic material to come into contact with blood that has passed through the release agent. 17. The device for promoting hemostasis of claim 16, wherein the mesh is flexible. 18. The device for promoting hemostasis of claim 16 wherein the hemostatic material is attapulgite, bentonite, kaolin, diatomaceous earth, and combinations of the foregoing materials. 19. The device for promoting hemostasis of claim 16 where the release agent is selected from the group consisting of polyvinyl alcohol, silicone, and gelatinized starch. 20. The receptacle of claim 16, wherein at least a portion of the receptacle comprises at least one material selected from the group consisting of oxidized cellulose, collagen, gelatinized starches, and guar gum.
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이 특허에 인용된 특허 (76)
McCabe John Patrick,GBX ; Stevens Peter John,GBX, Absorbent product.
Kaessmann Hans-Jurgen (Hamburg DEX) An Haak Karl W. (Am Hedreisch 25 D-44225 Dortmund DEX), Chitosan foil for wound sealing and process for its preparation.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Errede Louis A. (North Oaks MN) Stoesz James D. (St. Paul MN) Winter ; deceased George D. (late of St. Paul MN by Jenny Upton ; personal representative), Composite wound dressing.
Xu,Teng; Vaughn,Stephen Neil; Hall,Richard B.; Clem,Kenneth Ray; Johnson,Jack W., Low metal content catalyst compositions and processes for making and using same.
Myers Gene (2727 S. Tamiami Trail ; Suite 2A Sarasota FL 34239) Coury William S. (2830 Bay Shore Cir. Sarasota FL 34234), Method and apparatus for arteriotomy closure.
Farris Diane Dunn ; Hall Alicia Mary ; Osborn ; III Thomas Ward, Method for opening a packaging device and retrieving an interlabial absorbent article placed therein.
Scherson Daniel A. (2568 Saybrook Rd. University Hts. OH 44118) Burk Melvyn I. (21001 Halburton Rd. Beachwood OH 44122), Oxygen producing bandage and method.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Diegelmann, Robert F.; Ward, Kevin R.; Carr, Marcus E.; Bowlin, Gary Lee, Hemostasis of wound having high pressure blood flow using kaolin and bentonite.
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