IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0884774
(2006-02-23)
|
등록번호 |
US-8216801
(2012-07-10)
|
국제출원번호 |
PCT/IL2006/000249
(2006-02-23)
|
§371/§102 date |
20070920
(20070920)
|
국제공개번호 |
WO2006/090388
(2006-08-31)
|
발명자
/ 주소 |
|
출원인 / 주소 |
- The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), The Volcani Center
|
대리인 / 주소 |
Pearl Cohen Zedek Latzer, LLP
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
9 |
초록
▼
Provided are methods of treating an inflammatory disorder in a subject, including administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition including a fruit, for example a grape, cell culture, cultured fruit cells, fruit cell culture extract, or
Provided are methods of treating an inflammatory disorder in a subject, including administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition including a fruit, for example a grape, cell culture, cultured fruit cells, fruit cell culture extract, or cultured fruit cell extract, having an anti-inflammatory activity to treat the inflammatory disorder, wherein the inflammatory disorder is characterized by vascular endothelium dysfunction.
대표청구항
▼
1. A method for treating inflammation in a subject, comprising: administering to a subject an amount of a nutraceutical composition consisting essentially of a dried cell line callus culture of grape berry cells grown in vitro, whereby the cell line callus culture of grape berry cells is derived fro
1. A method for treating inflammation in a subject, comprising: administering to a subject an amount of a nutraceutical composition consisting essentially of a dried cell line callus culture of grape berry cells grown in vitro, whereby the cell line callus culture of grape berry cells is derived from one or more of grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat. 2. The method of claim 1, wherein cell line callus culture of grape berry cells grown in vitro is derived from a single cell or from heterogeneous cells. 3. The method of claim 1, wherein the grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat is derived from the group consisting of a colored grape and a non-colored grape. 4. The method of claim 1, wherein the grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat is derived from a wild grape variety. 5. The method of claim 1, wherein the grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat is derived from a cultivated grape variety. 6. The method of claim 1, wherein the nutraceutical composition is delivered mucosally by oral delivery, pharynx delivery, esophagus delivery, rectal delivery and vaginal delivery. 7. The method of claim 6, wherein the oral delivery is selected from the group consisting of buccal delivery and sublingual delivery. 8. The method of claim 6, wherein the nutraceutical composition is in a form selected from the group consisting of a mouthwash, a powder, a strip, a foam, a chewing gum, an oral spray, a lozenge, a capsule, a toothpaste and a food. 9. The method of claim 1, wherein the nutraceutical composition comprises less than 1% alcohol. 10. The method of claim 1, wherein nutraceutical composition or the dried cell line callus culture of grape berry cells grown in vitro is tasteless. 11. The method of claim 1, wherein the nutraceutical composition is tasteful. 12. The method of claim 1, wherein the cell line callus culture of grape berry cells grown in vitro comprises less than 10% sweetening sugar. 13. The method of claim 1, wherein the in vitro cultured grape cells comprise a genetic modification. 14. The method of claim 1, wherein the inflammation is caused by coronary heart disease. 15. The method of claim 14, wherein the coronary heart disease is atherosclerosis. 16. The method of claim 8, wherein the nutraceutical composition is administered to the subject in the form of a food additive to be ingested orally. 17. The method of claim 1, wherein the grape belongs to the vitis genus plant. 18. The method of claim 1, wherein the nutraceutical composition is in a form of a powder. 19. A method for alleviating inflammation in a subject, comprising: administering to a subject an amount of a nutraceutical composition consisting essentially of a dried cell line callus culture of grape berry cells grown in vitro, whereby the cell line callus culture of grape berry cells is derived-from one or more of grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat. 20. The method of claim 19, wherein the nutraceutical composition is in a form of a powder. 21. The method of claim 19, wherein the nutraceutical composition is administered to the subject in the form to be ingested orally. 22. The method of claim 19, wherein the nutraceutical composition or the dried cell line callus culture of grape berry cells grown in vitro is tasteless. 23. The method of claim 19, wherein the nutraceutical composition comprises less than 1% alcohol. 24. The method of claim 19, wherein the cell line callus culture of grape berry cells grown in vitro comprises less than 10% sweetening sugar. 25. A method for decreasing inflammatory marker ET1 and/or increasing inflammatory marker eNOS, comprising: administering an amount of a nutraceutical composition consisting essentially of a dried cell line callus culture of grape berry cells grown in vitro, whereby the cell line callus culture of grape berry cells is derived-from one or more of grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat. 26. The method of claim 25, wherein the nutraceutical composition is in a form of a powder. 27. The method of claim 25, wherein the nutraceutical composition is administered to the subject in the form to be ingested orally. 28. The method of claim 25, wherein the nutraceutical composition or the dried cell line callus culture of grape berry cells grown in vitro is tasteless. 29. The method of claim 25, wherein the nutraceutical composition comprises less than 1% alcohol. 30. The method of claim 25, wherein the cell line callus culture of grape berry cells grown in vitro comprises less than 10% sweetening sugar.
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