최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
---|---|
국제특허분류(IPC7판) |
|
출원번호 | US-0179034 (2008-07-24) |
등록번호 | US-8221500 (2012-07-17) |
발명자 / 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 15 인용 특허 : 413 |
The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structu
The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
1. A method for repairing a defect in articular cartilage of a human patient, said method comprising the steps of: (a) providing milled allograft cartilage pieces;(b) combining the milled allograft cartilage pieces with a biocompatible carrier to form a cartilage mixture;(c) providing a non-decellul
1. A method for repairing a defect in articular cartilage of a human patient, said method comprising the steps of: (a) providing milled allograft cartilage pieces;(b) combining the milled allograft cartilage pieces with a biocompatible carrier to form a cartilage mixture;(c) providing a non-decellularized osteochondral plug harvested from a human donor;(d) treating the non-decellularized osteochondral plug to remove cellular material, chondrocytes, pluripotent mesenchymal cells and proteoglycans therefrom;(e) lyophilizing the decellularized osteochondral plug to form a lyophilized decellularized osteochondral plug having a subchondral bone base and a cartilage cap attached to a first end of the subchondral bone base,(f) providing a plurality of passageways in the lyophilized, decellularized osteochondral plug, the passageways extending from the first end to a second end of the subchondral bone base;(g) implanting the cartilage mixture into a bore formed at the patient's articular cartilage defect; and(h) implanting the lyophilized, decellularized osteochondral plug into the bore so as to be in juxtaposition to the cartilage mixture, such that at least a portion of the cartilage mixture is received in the passageways to thereby promote chondrocyte migration into and proliferation within the cartilage cap, while enhancing tissue integration between the lyophilized, decellularized allograft osteochondral plug and patient tissue adjacent the bore. 2. The method of claim 1, wherein the lyophilized, decellularized osteochondral plug is cylindrically shaped. 3. The method of claim 1, wherein the passageways include throughgoing bores and said providing step (f) includes drilling the throughgoing bores in the subchondral bone base. 4. The method of claim 1, wherein the passageways include longitudinal grooves and said providing step (f) includes forming the longitudinal grooves on an outer surface of the lyophilized, decellularized osteochondral plug. 5. The method of claim 4, wherein said step (f) includes forming the longitudinal grooves on an outer surface of the subchondral bone base. 6. The method of claim 1, wherein the lyophilized, decellularized osteochondral plug has a diameter within a range of from 1 mm to 30 mm. 7. The method of claim 1, wherein the lyophilized, decellularized osteochondral plug has a diameter within a range of from about 3 mm to about 10 mm. 8. The method of claim 1, wherein the milled allograft cartilage pieces each have at least one dimension of less than 1 mm. 9. The method of claim 1, wherein the milled allograft cartilage pieces are hyaline cartilage. 10. The method of claim 1, wherein the cartilage mixture includes a chondrogenic stimulating factor. 11. The method of claim 10, wherein the chondrogenic stimulating factor is one or more of a group consisting of growth factors (FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide and bioactive glue. 12. The method of claim 1, wherein the biocompatible carrier comprises one or more of a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran and polymers. 13. The method of claim 1, wherein the cartilage mixture includes milled allograft cartilage pieces which have been lyophilized so that their water content is within a range of from about 0.1% to about 8.0%. 14. The method of claim 1, wherein the milled allograft cartilage pieces constitute a weight percentage of the cartilage mixture within a range of from about 25% to about 50%. 15. The method of claim 1, wherein the milled allograft cartilage pieces constitute a weight percentage of the cartilage mixture within a range of from about 15% to about 30%. 16. The method of claim 1, wherein the lyophilized, decellularized osteochondral plug has a water content in the range of from about 0.1% to about 8.0%. 17. The method of claim 1, wherein the cartilage mixture includes an additive consisting of one or more of a group consisting of human allogenic cartilage cells, and human bone marrow cells. 18. The method of claim 1, wherein the bore is cylindrical and transverse to the cartilage surface surrounding the bore. 19. The method of claim 1, wherein the bore is cylindrical and angled with respect to the cartilage surface surrounding the bore. 20. The method of claim 1, wherein said step (h) is performed to create an interference fit between the lyophilized, decellularized osteochondral plug and an inner surface of the bore. 21. The method of claim 1, wherein said step (h) is performed such that the cartilage cap of the lyophilized, decellularized osteochondral plug is substantially flush with the surface of the patient's adjacent cartilage. 22. The method of claim 1, wherein said step (g) is performed prior to said step (h).
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.