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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0569159 (2009-09-29) |
등록번호 | US-8226815 (2012-07-24) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 452 |
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agen
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
1. A method of determining a concentration of an analyte in a sample using an electrochemical sensor, the method comprising: contacting a sample with an electrochemical sensor;drawing at least a portion of the sample through one of a first and a second aperture and into a sample chamber;observing a
1. A method of determining a concentration of an analyte in a sample using an electrochemical sensor, the method comprising: contacting a sample with an electrochemical sensor;drawing at least a portion of the sample through one of a first and a second aperture and into a sample chamber;observing a signal from a first indicator electrode to signify that the sample chamber is beginning to fill with sample;observing a signal from a second indicator electrode to signify that the sample chamber is sufficiently full for determining the concentration of the analyte using the sensor; andgenerating a analyte-responsive signal from the sensor in response to electrolysis of the analyte in the sample to determine the concentration of the analyte in the sample. 2. The method of claim 1, wherein generating a analyte-responsive signal comprises generating the ketone-responsive signal using the working electrode, the counter electrode, and at least one of the first and second indicator electrodes. 3. The method of claim 1, wherein the step of generating a analyte-responsive signal occurs simultaneously with and continues after the step of observing the second indicator electrode. 4. The method of claim 1, wherein the step of generating a analyte-responsive signal occurs after the step of observing the second indicator electrode. 5. The method of claim 1, wherein the concentration of the analyte is determined using coulometry. 6. The method of claim 1, wherein the concentration of the analyte is determined using amperometry. 7. The method of claim 1, wherein the concentration of the analyte is determined using potentiometry. 8. The method of claim 1, wherein the analyte is glucose or a ketone. 9. The method of claim 8, wherein the analyte is glucose. 10. The method of claim 9, wherein the sensor comprises a glucose-responsive enzyme selected from glucose dehydrogenase and glucose oxidase. 11. The method of claim 1, further comprising obtaining the sample from a finger of a subject. 12. The method of claim 1, further comprising obtaining the sample from a region of a subject having a lower nerve end density as compared to a fingertip. 13. The method of claim 12, wherein the region of a subject having a lower nerve end density as compared to a fingertip is selected from the group consisting of: a forearm region, and a thigh region.
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