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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0572599 (2009-10-02) |
등록번호 | US-8246945 (2012-08-21) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 5 인용 특허 : 78 |
The present invention provides methods and compositions for treating or preventing allergic reactions, particularly anaphylactic reactions. Methods of the present invention involve administering microorganisms to allergic subjects, where the microorganisms contain a recombinant version of the protei
The present invention provides methods and compositions for treating or preventing allergic reactions, particularly anaphylactic reactions. Methods of the present invention involve administering microorganisms to allergic subjects, where the microorganisms contain a recombinant version of the protein allergen. The recombinant version can be wild-type or may include mutations within IgE epitopes of the protein allergen. Preferably the compositions are administered rectally. Particularly preferred microorganisms are bacteria such as E. coli. Any allergen may be used in the inventive methods. Particularly preferred allergens are anaphylactic allergens including protein allergens found in foods, venoms, drugs and latex. The inventive compositions and methods are demonstrated in the treatment of peanut-induced anaphylaxis.
1. A method of treating allergy in a subject susceptible to an allergic response to a protein allergen, the method comprising a step of: administering to a subject, via the subject's rectum, a composition comprising:dead E. coli that has expressed a protein allergen selected from the group consistin
1. A method of treating allergy in a subject susceptible to an allergic response to a protein allergen, the method comprising a step of: administering to a subject, via the subject's rectum, a composition comprising:dead E. coli that has expressed a protein allergen selected from the group consisting of:Ambrosia artemisiifolia (short ragweed) antigen E (Amb a 1);Ambrosia artemisiifolia (short ragweed) antigen K (Amb a 2);Ambrosia artemisiifolia (short ragweed) Ra3 antigen (Amb a 3);Ambrosia artemisiifolia (short ragweed) Ra5 antigen (Amb a 5);Ambrosia artemisiifolia (short ragweed) Ra6 antigen (Amb a 6);Ambrosia artemisiifolia (short ragweed) Ra7 antigen (Amb a 7);Ambrosia trifida (giant ragweed) Ra5G antigen (Amb t 5);Artemisia vulgaris (mugwort) antigen (Art v 1);Artemisia vulgaris (mugwort) antigen (Art v 2);Helianthus annuus (sunflower) antigen (Hel a 1);Helianthus annuus (sunflower) profilin (Hel a 2);Mercurialis annua (annual mercury) profilin (Mer a 1);Cynodon dactylon (Bermuda grass) antigen (Cyn d 1);Cynodon dactylon (Bermuda grass) antigen (Cyn d 7);Cynodon dactylon (Bermuda grass) profilin (Cyn d 12);Dactylis glomerata (orchard grass) AgDg1 antigen (Dac g 1);Dactylis glomerata (orchard grass) antigen (Dac g 2);Dactylis glomerata (orchard grass) antigen (Dac g 3);Dactylis glomerata (orchard grass) antigen (Dac g 5);Holcus lanatus (velvet grass) antigen (Hol l 1);Lolium perenne (rye grass) group I antigen (Lol p 1);Lolium perenne (rye grass) group II antigen (Lol p 2);Lolium perenne (rye grass) group III antigen (Lol p 3);Lolium perenne (rye grass) group IX antigen (Lol p 5);Lolium perenne (rye grass) antigen (Lol p Ib);Lolium perenne (rye grass) trypsin (Lol p 11);Phalaris aquatica (canary grass) antigen (Pha a 1);Phleum pratense (timothy grass) antigen (Phl p 1);Phleum pratense (timothy grass) antigen (Phl p 2);Phleum pratense (timothy grass) antigen (Phl p 4);Phleum pratense (timothy grass) antigen Ag 25 (Phl p 5);Phleum pratense (timothy grass) antigen (Phl p 6);Phleum pratense (timothy grass) profilin (Phl p 12);Phleum pratense (timothy grass) polygalacturonase (Phl p 13);Poa pratensis (Kentucky blue grass) group I antigen (Poa p 1);Poa pratensis (Kentucky blue grass) antigen (Poa p 5);Sorghum halepense (Johnson grass) antigen (Sor h 1);Alnus glutinosa (alder) antigen (Aln g 1);Betula verrucosa (birch) antigen (Bet v 1);Betula verrucosa (birch) profilin (Bet v 2);Betula verrucosa (birch) antigen (Bet v 3);Betula verrucosa (birch) antigen (Bet v 4);Betula verrucosa (birch) isoflavone reductase homologue (Bet v 5);Betula verrucosa (birch) cyclophilin (Bet v 7);Carpinus betulus (hornbeam) antigen (Car b 1);Castanea sativa (chestnut) Bet v 1 homologue (Cas s 1);Castanea sativa (chestnut) chitinase (Cas s 5);Corylus avelana (hazel) antigen (Cor a 1);Quercus alba (white oak) antigen (Que a 1);Cryptomeria japonica (sugi) antigen (Cry j 1);Cryptomeria japonica (sugi) antigen (Cry j 2);Juniperus ashei (mountain cedar) antigen (Jun a 1);Juniperus ashei (mountain cedar) antigen (Jun a 3);Juniperus oxycedrus (prickly juniper) calmodulin-like antigen (Jun o 2);Juniperus sabinoides (mountain cedar) antigen (Jun s 1);Juniperus virginiana (eastern red cedar) antigen (Jun v 1);Fraxinus excelsior (ash) antigen (Fra e 1);Ligustrum vulgare (privet) antigen (Lig v 1);Olea europea (olive) antigen (Ole e 1);Olea europea (olive) profilin (Ole e 2);Olea europea (olive) antigen (Ole e 3);Olea europea (olive) antigen (Ole e 4);Olea europea (olive) superoxide dismutase (Ole e 5);Olea europea (olive) antigen (Ole e 6);Syringa vulgaris (lilac) antigen (Syr v 1);Acarus siro (mite) fatty acid-binding protein (Aca s 13);Blomia tropicalis (mite) antigen (Blo t 5);Blomia tropicalis (mite) Bt11a antigen (Blo t 12);Blomia tropicalis (mite) Bt6 fatty acid-binding protein (Blo t);Dermatophagoides pteronyssinus (mite) antigen P1 (Der p 1);Dermatophagoides pteronyssinus (mite) antigen (Der p 2);Dermatophagoides pteronyssinus (mite) trypsin (Der p 3);Dermatophagoides pteronyssinus (mite) amylase (Der p 4);Dermatophagoides pteronyssinus (mite) antigen (Der p 5);Dermatophagoides pteronyssinus (mite) chymotrypsin (Der p 6);Dermatophagoides pteronyssinus (mite) antigen (Der p 7);Dermatophagoides pteronyssinus (mite) glutathione transferase (Der p 8);Dermatophagoides pteronyssinus (mite) collagenolytic serine prot (Der p 9);Dermatophagoides pteronyssinus (mite) tropomyosin (Der p 10);Dermatophagoides pteronyssinus (mite) apolipophorin like p (Der p 14);Dermatophagoides microceras (mite) antigen (Der m 1);Dermatophagoides farinae (mite) antigen (Der f 1);Dermatophagoides farinae (mite) antigen (Der f 2);Dermatophagoides farinae (mite) antigen (Der f 3);Dermatophagoides farinae (mite) tropomyosin (Der f 10);Dermatophagoides farinae (mite) paramyosin (Der f 11);Dermatophagoides farinae (mite) Mag 3, apolipophorin (Der f 14);Euroglyphus maynei (mite) apolipophorin (Eur m 14);Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0101);Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0102);Bos domesticus (cow) Ag3, lipocalin (Bos d 2);Bos domesticus (cow) alpha-lactalbumin (Bos d 4);Bos domesticus (cow) beta-lactalbumin (Bos d 5);Bos domesticus (cow) serum albumin (Bos d 6);Bos domesticus (cow) immunoglobulin (Bos d 7);Bos domesticus (cow) casein (Bos d 8);Canis familiaris (dog) antigen (Can f 1);Canis familiaris (dog) antigen (Can f 2);Canis familiaris (dog) albumin (Can f ?);Equus caballus (horse) lipocalin (Equ c 1);Equus caballus (horse) lipocalin (Equ c 2);Felis domesticus (cat) cat-1 antigen (Fel d 1);Mus musculus (mouse) MUP antigen (Mus m 1);Rattus norvegius (rat) antigen (Rat n 1);Alternaria alternata (fungus) antigen (Alt a 1);Alternaria alternata (fungus) antigen (Alt a 2);Alternaria alternata (fungus) heat shock protein (Alt a 3);Alternaria alternata (fungus) ribosomal protein (Alt a 6);Alternaria alternata (fungus) YCP4 protein (Alt a 7);Alternaria alternata (fungus) aldehyde dehydrogenase (Alt a 10);Alternaria alternata (fungus) enloase (Alt a 11);Alternaria alternata (fungus) acid ribosomal protein P1 (Alt a 12);Cladosporium herbarum (fungus) antigen (Cla h 1);Cladosporium herbarum (fungus) antigen (Cla h 2);Cladosporium herbarum (fungus) aldehyde dehydrogenase (Cla h 3);Cladosporium herbarum (fungus) ribosomal protein);Cladosporium herbarum (fungus) YCP4 protein (Cla h 5);Cladosporium herbarum (fungus) enolase (Cla h 6);Cladosporium herbarum (fungus) acid ribosomal protein P1 (Cla h 12);Aspergillus flavus (fungus) alkaline serine proteinase (Asp fl 13);Aspergillus Fumigatus (fungus) antigen (Asp f 1);Aspergillus Fumigatus (fungus) antigen (Asp f 2);Aspergillus Fumigatus (fungus) peroxisomal protein (Asp f 3);Aspergillus Fumigatus (fungus) antigen (Asp f 4);Aspergillus Fumigatus (fungus) metalloprotease (Asp f 5);Aspergillus Fumigatus (fungus) Mn superoxide dismutase (Asp f 6);Aspergillus Fumigatus (fungus) antigen (Asp f 7);Aspergillus Fumigatus (fungus) ribosomal protein P2 (Asp f 8);Aspergillus Fumigatus (fungus) antigen (Asp f 9);Aspergillus Fumigatus (fungus) aspartis protease (Asp f 10);Aspergillus Fumigatus (fungus) peptidyl-prolyl isomerase (Asp f 11);Aspergillus Fumigatus (fungus) heat shock protein P70 (Asp f 12);Aspergillus Fumigatus (fungus) alkaline serine proteinase (Asp f 13);Aspergillus Fumigatus (fungus) antigen (Asp f 15);Aspergillus Fumigatus (fungus) antigen (Asp f 16);Aspergillus Fumigatus (fungus) antigen (Asp f 17);Aspergillus Fumigatus (fungus) vacuolar serine (Asp f 18);Aspergillus niger (fungus) beta-xylosidase (Asp n 14);Aspergillus niger (fungus) antigen (Asp n 18);Aspergillus niger (fungus) vacuolar serine proteinase;Aspergillus oryzae (fungus) TAKA-amylase A (Asp o 2);Aspergillus oryzae (fungus) alkaline serine proteinase (Asp o 13);Penicillium brevicompactum (fungus) alkaline serine proteinase (Pen b 13);Penicillium citrinum (fungus) heat shock protein P70 (Pen c 1);Penicillium citrinum (fungus) peroxisomal membrane protein (Pen c 3);Penicillium citrinum (fungus) alkaline serine proteinase (Pen c 13);Penicillium notatum (fungus) N-acetyl glucosaminidase (Pen n 1);Penicillium notatum (fungus) alkaline serine proteinase (Pen n 13);Penicillium notatum (fungus) vacuolar serine proteinase (Pen n 18);Penicillium oxalicum (fungus) vacuolar serine proteinase (Pen o 18);Trichophyton rubrum (fungus) antigen (Tri r 2);Trichophyton rubrum (fungus) serine protease (Tri r 4);Trichophyton tonsurans (fungus) antigen (Tri t 1);Trichophyton tonsurans (fungus) serine protease (Tri t 4);Candida albicans (fungus) antigen (Cand a 1);Candida boidinii (fungus) antigen (Cand b 2);Malassezia furfur (fungus) antigen (Mal f 1);Malassezia furfur (fungus) MF1 peroxisomal membrane protein (Mal f 2);Malassezia furfur (fungus) MF2 peroxisomal membrane protein (Mal f 3);Malassezia furfur (fungus) antigen (Mal f 4);Malassezia furfur (fungus) antigen (Mal f 5);Malassezia furfur (fungus) cyclophilin homologue (Mal f 6);Psilocybe cubensis (fungus) antigen (Psi c 1);Psilocybe cubensis (fungus) cyclophilin (Psi c 2);Coprinus comatus (shaggy cap) antigen (Cop c 1);Coprinus comatus (shaggy cap) antigen (Cop c 2);Coprinus comatus (shaggy cap) antigen (Cop c 3);Coprinus comatus (shaggy cap) antigen (Cop c 5);Coprinus comatus (shaggy cap) antigen (Cop c 7);Aedes aegyptii (mosquito) apyrase (Aed a 1);Aedes aegyptii (mosquito) antigen (Aed a 2);Apis mellifera (honey bee) phospholipase A2 (Api m 1);Apis mellifera (honey bee) hyaluronidase (Api m 2);Apis mellifera (honey bee) melittin (Api m 4);Apis mellifera (honey bee) antigen (Api m 6);Bombus pennsylvanicus (bumble bee) phospholipase (Bom p 1);Bombus pennsylvanicus (bumble bee) protease (Bom p 4);Blattella germanica (German cockroach) Bd90k (Bla g 1);Blattella germanica (German cockroach) aspartic protease (Bla g 2);Blattella germanica (German cockroach) calycin (Bla g 4);Blattella germanica (German cockroach) glutathione transferase (Bla g 5);Blattella germanica (German cockroach) troponin C (Bla g 6);Periplaneta americana (American cockroach) Cr-PII (Per a 1);Periplaneta americana (American cockroach) Cr-PI (Per a 3);Periplaneta americana (American cockroach) tropomyosin (Per a 7);Chironomus thummi thummi (midge) hemoglobin (Chi t 1-9);Chironomus thummi thummi (midge) component III (Chi t 1.01);Chironomus thummi thummi (midge) component IV (Chi t 1.02);Chironomus thummi thummi (midge) component I (Chi t 2.0101);Chironomus thummi thummi (midge) component IA (Chi t 2.0102);Chironomus thummi thummi (midge) component II-beta (Chi t 3);Chironomus thummi thummi (midge) component IIIA (Chi t 4);Chironomus thummi thummi (midge) component VI (Chi t 5);Chironomus thummi thummi (midge) component VIIA (Chi t 6.01);Chironomus thummi thummi (midge) component IX (Chi t 6.02);Chironomus thummi thummi (midge) component VIIB (Chi t 7);Chironomus thummi thummi (midge) component VIII (Chi t 8);Chironomus thummi thummi (midge) component X (Chi t 9);Dolichovespula maculata (white face hornet) phospholipase (Dol m 1);Dolichovespula maculata (white face hornet) hyaluronidase (Dol m 2);Dolichovespula maculata (white face hornet) antigen 5 (Dol m 5);Dolichovespula arenaria (yellow hornet) antigen 5 (Dol a 5);Polistes annularies (wasp) phospholipase A1 (Pol a 1);Polistes annularies (wasp) hyaluronidase (Pol a 2);Polistes annularies (wasp) antigen 5 (Pol a 5);Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 1);Polistes dominulus (Mediterranean paper wasp) serine protease (Pol d 4);Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 5);Polistes exclamans (wasp) phospholipase A1 (Pol e 1);Polistes exclamans (wasp) antigen 5 (Pol e 5);Polistes fuscatus (wasp) antigen 5 (Pol f 5);Polistes metricus (wasp) antigen 5 (Pol m 5);Vespa crabo (European hornet) phospholipase (Vesp c 1);Vespa crabo (European hornet) antigen 5 (Vesp c 5.0101);Vespa crabo (European hornet) antigen 5 (Vesp c 5.0102);Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.01);Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.02);Vespa mandarina (giant Asian hornet) antigen (Vesp m 5);Vespula flavopilosa (yellowjacket) antigen 5 (Ves f 5);Vespula germanica (yellowjacket) antigen 5 (Ves g 5);Vespula maculifrons (yellowjacket) phospholipase A1 (Ves m 1);Vespula maculifrons (yellowjacket) hyaluronidase (Ves m 2);Vespula maculifrons (yellowjacket) antigen 5 (Ves m 5);Vespula pennsylvanica (yellowjacket) (antigen 5Ves p 5);Vespula squamosa (yellowjacket) antigen 5 (Ves s 5);Vespula vidua (wasp) antigen (Ves vi 5);Vespula vulgaris (yellowjacket) phospholipase A1 (Ves v 1);Vespula vulgaris (yellowjacket) hyaluronidase (Ves v 2);Vespula vulgaris (yellowjacket) antigen 5 (Ves v 5);Myrmecia pilosula (Australian jumper ant) antigen (Myr p 1);Myrmecia pilosula (Australian jumper ant) antigen (Myr p 2);Solenopsis geminata (tropical fire ant) antigen (Sol g 2);Solenopsis geminata (tropical fire ant) antigen (Sol g 4);Solenopsis invicta (fire ant) antigen (Sol i 2);Solenopsis invicta (fire ant) antigen (Sol i 3);Solenopsis invicta (fire ant) antigen (Sol i 4);Solenopsis saevissima (Brazilian fire ant) antigen (Sol s 2);Gadus callarias (cod) allergen M (Gad c 1);Salmo salar (Atlantic salmon) parvalbumin (Sal s 1);Gallus domesticus (chicken) ovomucoid (Gal d 1);Gallus domesticus (chicken) ovalbumin (Gal d 2);Gallus domesticus (chicken) conalbumin; A22 (Gal d 3);Gallus domesticus (chicken) lysozyme (Gal d 4);Gallus domesticus (chicken) serum albumin (Gal d 5);Metapenaeus ensis (shrimp) tropomyosin (Met e 1);Penaeus aztecus (shrimp) tropomyosin (Pen a 1);Penaeus indicus (shrimp) tropomyosin (Pen i 1);Todarodes pacificus (squid) tropomyosin (Tod p 1);Haliotis Midae (abalone) antigen (Hal m 1);Apium graveolens (celery) Bet v 1 homologue (Api g 1);Apium graveolens (celery) profilin (Api g 4);Apium graveolens (celery) antigen (Api g 5);Brassica juncea (oriental mustard) 2S albumin (Bra j 1);Brassica rapa (turnip) prohevein-like protein (Bar r 2);Hordeum vulgare (barley) BMAI-1 (Hor v 1);Zea mays (maize, corn) lipid transfer protein (Zea m 14);Corylus avellana (hazelnut) Bet v 1 homologue (Cor a 1.0401);Malus domestica (apple) Bet v 1 homologue (Mal d 1);Malus domestica (apple) lipid transfer protein (Mal d 3);Pyrus communis (pear) Bet v 1 homologue (Pyr c 1);Pyrus communis (pear) profilin (Pyr c 4);Pyrus communis (pear) isoflavone reductase homologue (Pyr c 5);Oryza sativa (rice) antigen (Ory s 1);Persea americana (avocado) endochitinase (Pers a 1);Prunus armeniaca (apricot) Bet v 1 homologue (Pru ar 1);Prunus armeniaca (apricot) lipid transfer protein (Pru ar 3);Prunus avium (sweet cherry) Bet v 1 homologue (Pru av 1);Prunus avium (sweet cherry) thaumatin homologue (Pru av 2);Prunus avium (sweet cherry) profilin (Pru av 4);Prunus persica (peach) lipid transfer protein (Pru p 3);Sinapis alba (yellow mustard) 2S albumin (Sin a 1);Glycine max (soybean) HPS (Gly m 1.0101);Glycine max (soybean) HPS (Gly m 1.0102);Glycine max (soybean) antigen (Gly m 2);Glycine max (soybean) profilin (Gly m 3);Arachis hypogaea (peanut) vicilin (Ar a h 1);Arachis hypogaea (peanut) (conglutin Ar a h 2);Arachis hypogaea (peanut) glycinin (Ar a h 3);Arachis hypogaea (peanut) glycinin (Ar a h 4);Arachis hypogaea (peanut) (profilin Ar a h 5);Arachis hypogaea (peanut) conglutin homologue (Ar a h 6);Arachis hypogaea (peanut) conglutin homologue (Ar a h 7);Actinidia chinensis (kiwi) cysteine protease (Act c 1);Solanum tuberosum (potato) patatin (Sol t 1);Bertholletia excelsa (Brazil nut) 2S albumin (Ber e 1);Juglans regia (English walnut) 2S albumin (Jug r 1);Juglans regia (English walnut) vicilin (Jug r 2);Ricinus communis (castor bean) 2S albumin (Ric c 1);Anisakis simplex (nematode) antigen (Ani s 1);Anisakis simplex (nematode) paramyosin (Ani s 2);Ascaris suum (worm) antigen (Asc s 1);Aedes aegyptii (mosquito) apyrase (Aed a 1);Aedes aegyptii (mosquito) antigen (Aed a 2);Hevea brasiliensis (rubber) elongation factor (Hev b 1);Hevea brasiliensis (rubber) 1,3-glucanase (Hev b 2);Hevea brasiliensis (rubber) antigen (Hev b 3);Hevea brasiliensis (rubber) component of microhelix protein complex (Hev b 4);Hevea brasiliensis (rubber) antigen (Hev b 5);Hevea brasiliensis (rubber) hevein precursor (Hev b 6.01);Hevea brasiliensis (rubber) hevein (Hev b 6.02);Hevea brasiliensis (rubber) C-terminal fragment antigen (Hev b 6.03);Hevea brasiliensis (rubber) patatin homologue (Hev b 7);Hevea brasiliensis (rubber) profilin (Hev b 8);Hevea brasiliensis (rubber) enolase (Hev b 9);Hevea brasiliensis (rubber) Mn-superoxide dismut (Hev b 10);Ctenocephalides felis felis (cat flea) antigen (Cte f 1);Homo sapiens (human autoallergen) antigen (Hom s 1);Homo sapiens (human autoallergen) antigen (Hom s 2);Homo sapiens (human autoallergen) antigen (Hom s 3);Homo sapiens (human autoallergen) antigen (Hom s 4); andHomo sapiens (human autoallergen) antigen (Hom s 5),the expressed protein allergen being encapsulated within the dead E. coli, so that the expressed protein allergen is not exposed to the subject's IgE antibodies during administration; and a pharmaceutically acceptable carrier, so that one or more symptoms of the subject's allergy to the protein allergen is reduced or decreased. 2. A method of treating allergy in a subject susceptible to an allergic response to a protein allergen, the method comprising a step of: administering to a subject, via the subject's rectum, a composition comprising:dead E. coli that has expressed a protein allergen selected from the group consisting of:Ambrosia artemisiifolia (short ragweed) antigen E (Amb a 1);Ambrosia artemisiifolia (short ragweed) antigen K (Amb a 2);Ambrosia artemisiifolia (short ragweed) Ra3 antigen (Amb a 3);Ambrosia artemisiifolia (short ragweed) Ra5 antigen (Amb a 5);Ambrosia artemisiifolia (short ragweed) Ra6 antigen (Amb a 6);Ambrosia artemisiifolia (short ragweed) Ra7 antigen (Amb a 7);Ambrosia trifida (giant ragweed) Ra5G antigen (Amb t 5);Artemisia vulgaris (mugwort) antigen (Art v 1);Artemisia vulgaris (mugwort) antigen (Art v 2);Helianthus annuus (sunflower) antigen (Hel a 1);Helianthus annuus (sunflower) profilin (Hel a 2);Mercurialis annua (annual mercury) profilin (Mer a 1);Cynodon dactylon (Bermuda grass) antigen (Cyn d 1);Cynodon dactylon (Bermuda grass) antigen (Cyn d 7);Cynodon dactylon (Bermuda grass) profilin (Cyn d 12);Dactylis glomerata (orchard grass) AgDg1 antigen (Dac g 1);Dactylis glomerata (orchard grass) antigen (Dac g 2);Dactylis glomerata (orchard grass) antigen (Dac g 3);Dactylis glomerata (orchard grass) antigen (Dac g 5);Holcus lanatus (velvet grass) antigen (Hol l 1);Lolium perenne (rye grass) group I antigen (Lol p 1);Lolium perenne (rye grass) group II antigen (Lol p 2);Lolium perenne (rye grass) group III antigen (Lol p 3);Lolium perenne (rye grass) group IX antigen (Lol p 5);Lolium perenne (rye grass) antigen (Lol p Ib);Lolium perenne (rye grass) trypsin (Lol p 11);Phalaris aquatica (canary grass) antigen (Pha a 1);Phleum pratense (timothy grass) antigen (Phl p 1);Phleum pratense (timothy grass) antigen (Phl p 2);Phleum pratense (timothy grass) antigen (Phl p 4);Phleum pratense (timothy grass) antigen Ag 25 (Phl p 5);Phleum pratense (timothy grass) antigen (Phl p 6);Phleum pratense (timothy grass) profilin (Phl p 12);Phleum pratense (timothy grass) polygalacturonase (Phl p 13);Poa pratensis (Kentucky blue grass) group I antigen (Poa p 1);Poa pratensis (Kentucky blue grass) antigen (Poa p 5);Sorghum halepense (Johnson grass) antigen (Sor h 1);Alnus glutinosa (alder) antigen (Aln g 1);Betula verrucosa (birch) antigen (Bet v 1);Betula verrucosa (birch) profilin (Bet v 2);Betula verrucosa (birch) antigen (Bet v 3);Betula verrucosa (birch) antigen (Bet v 4);Betula verrucosa (birch) isoflavone reductase homologue (Bet v 5);Betula verrucosa (birch) cyclophilin (Bet v 7);Carpinus betulus (hornbeam) antigen (Car b 1);Castanea sativa (chestnut) Bet v 1 homologue (Cas s 1);Castanea sativa (chestnut) chitinase (Cas s 5);Corylus avelana (hazel) antigen (Cor a 1);Quercus alba (white oak) antigen (Que a 1);Cryptomeria japonica (sugi) antigen (Cry j 1);Cryptomeria japonica (sugi) antigen (Cry j 2);Juniperus ashei (mountain cedar) antigen (Jun a 1);Juniperus ashei (mountain cedar) antigen (Jun a 3);Juniperus oxycedrus (prickly juniper) calmodulin-like antigen (Jun o 2);Juniperus sabinoides (mountain cedar) antigen (Jun s 1);Juniperus virginiana (eastern red cedar) antigen (Jun v 1);Fraxinus excelsior (ash) antigen (Fra e 1);Ligustrum vulgare (privet) antigen (Lig v 1);Olea europea (olive) antigen (Ole e 1);Olea europea (olive) profilin (Ole e 2);Olea europea (olive) antigen (Ole e 3);Olea europea (olive) antigen (Ole e 4);Olea europea (olive) superoxide dismutase (Ole e 5);Olea europea (olive) antigen (Ole e 6);Syringa vulgaris (lilac) antigen (Syr v 1);Acarus siro (mite) fatty acid-binding protein (Aca s 13);Blomia tropicalis (mite) antigen (Blo t 5);Blomia tropicalis (mite) Bt11a antigen (Blo t 12);Blomia tropicalis (mite) Bt6 fatty acid-binding protein (Blo t);Dermatophagoides pteronyssinus (mite) antigen P1 (Der p 1);Dermatophagoides pteronyssinus (mite) antigen (Der p 2);Dermatophagoides pteronyssinus (mite) trypsin (Der p 3);Dermatophagoides pteronyssinus (mite) amylase (Der p 4);Dermatophagoides pteronyssinus (mite) antigen (Der p 5);Dermatophagoides pteronyssinus (mite) chymotrypsin (Der p 6);Dermatophagoides pteronyssinus (mite) antigen (Der p 7);Dermatophagoides pteronyssinus (mite) glutathione transferase (Der p 8);Dermatophagoides pteronyssinus (mite) collagenolytic serine prot. (Der p 9);Dermatophagoides pteronyssinus (mite) tropomyosin (Der p 10);Dermatophagoides pteronyssinus (mite) apolipophorin like p (Der p 14);Dermatophagoides microceras (mite) antigen (Der m 1);Dermatophagoides farinae (mite) antigen (Der f 1);Dermatophagoides farinae (mite) antigen (Der f 2);Dermatophagoides farinae (mite) antigen (Der f 3);Dermatophagoides farinae (mite) tropomyosin (Der f 10);Dermatophagoides farinae (mite) paramyosin (Der f 11);Dermatophagoides farinae (mite) Mag 3, apolipophorin (Der f 14);Euroglyphus maynei (mite) apolipophorin (Eur m 14);Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0101);Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0102);Bos domesticus (cow) Ag3, lipocalin (Bos d 2);Bos domesticus (cow) alpha-lactalbumin (Bos d 4);Bos domesticus (cow) beta-lactalbumin (Bos d 5);Bos domesticus (cow) serum albumin (Bos d 6);Bos domesticus (cow) immunoglobulin (Bos d 7);Bos domesticus (cow) casein (Bos d 8);Canis familiaris (dog) antigen (Can f 1);Canis familiaris (dog) antigen (Can f 2);Canis familiaris (dog) albumin (Can f ?);Equus caballus (horse) lipocalin (Equ c 1);Equus caballus (horse) lipocalin (Equ c 2);Felis domesticus (cat) cat-1 antigen (Fel d 1);Mus musculus (mouse) MUP antigen (Mus m 1);Rattus norvegius (rat) antigen (Rat n 1);Alternaria alternata (fungus) antigen (Alt a 1);Alternaria alternata (fungus) antigen (Alt a 2);Alternaria alternata (fungus) heat shock protein (Alt a 3);Alternaria alternata (fungus) ribosomal protein (Alt a 6);Alternaria alternata (fungus) YCP4 protein (Alt a 7);Alternaria alternata (fungus) aldehyde dehydrogenase (Alt a 10);Alternaria alternata (fungus) enloase (Alt a 11);Alternaria alternata (fungus) acid ribosomal protein P1 (Alt a 12);Cladosporium herbarum (fungus) antigen (Cla h 1);Cladosporium herbarum (fungus) antigen (Cla h 2);Cladosporium herbarum (fungus) aldehyde dehydrogenase (Cla h 3);Cladosporium herbarum (fungus) ribosomal protein);Cladosporium herbarum (fungus) YCP4 protein (Cla h 5);Cladosporium herbarum (fungus) enolase (Cla h 6);Cladosporium herbarum (fungus) acid ribosomal protein P1 (Cla h 12);Aspergillus flavus (fungus) alkaline serine proteinase (Asp fl 13);Aspergillus Fumigatus (fungus) antigen (Asp f 1);Aspergillus Fumigatus (fungus) antigen (Asp f 2);Aspergillus Fumigatus (fungus) peroxisomal protein (Asp f 3);Aspergillus Fumigatus (fungus) antigen (Asp f 4);Aspergillus Fumigatus (fungus) metalloprotease (Asp f 5);Aspergillus Fumigatus (fungus) Mn superoxide dismutase (Asp f 6);Aspergillus Fumigatus (fungus) antigen (Asp f 7);Aspergillus Fumigatus (fungus) ribosomal protein P2 (Asp f 8);Aspergillus Fumigatus (fungus) antigen (Asp f 9);Aspergillus Fumigatus (fungus) aspartis protease (Asp f 10);Aspergillus Fumigatus (fungus) peptidyl-prolyl isomerase (Asp f 11);Aspergillus Fumigatus (fungus) heat shock protein P70 (Asp f 12);Aspergillus Fumigatus (fungus) alkaline serine proteinase (Asp f 13);Aspergillus Fumigatus (fungus) antigen (Asp f 15);Aspergillus Fumigatus (fungus) antigen (Asp f 16);Aspergillus Fumigatus (fungus) antigen (Asp f 17);Aspergillus Fumigatus (fungus) vacuolar serine (Asp f 18);Aspergillus niger (fungus) beta-xylosidase (Asp n 14);Aspergillus niger (fungus) antigen (Asp n 18);Aspergillus niger (fungus) vacuolar serine proteinase;Aspergillus oryzae (fungus) TAKA-amylase A (Asp o 2);Aspergillus oryzae (fungus) alkaline serine proteinase (Asp o 13);Penicillium brevicompactum (fungus) alkaline serine proteinase (Pen b 13);Penicillium citrinum (fungus) heat shock protein P70 (Pen c 1);Penicillium citrinum (fungus) peroxisomal membrane protein (Pen c 3);Penicillium citrinum (fungus) alkaline serine proteinase (Pen c 13);Penicillium notatum (fungus) N-acetyl glucosaminidase (Pen n 1);Penicillium notatum (fungus) alkaline serine proteinase (Pen n 13);Penicillium notatum (fungus) vacuolar serine proteinase (Pen n 18);Penicillium oxalicum (fungus) vacuolar serine proteinase (Pen o 18);Trichophyton rubrum (fungus) antigen (Tri r 2);Trichophyton rubrum (fungus) serine protease (Tri r 4);Trichophyton tonsurans (fungus) antigen (Tri t 1);Trichophyton tonsurans (fungus) serine protease (Tri t 4);Candida albicans (fungus) antigen (Cand a 1);Candida boidinii (fungus) antigen (Cand b 2);Malassezia furfur (fungus) antigen (Mal f 1);Malassezia furfur (fungus) MF1 peroxisomal membrane protein (Mal f 2);Malassezia furfur (fungus) MF2 peroxisomal membrane protein (Mal f 3);Malassezia furfur (fungus) antigen (Mal f 4);Malassezia furfur (fungus) antigen (Mal f 5);Malassezia furfur (fungus) cyclophilin homologue (Mal f 6);Psilocybe cubensis (fungus) antigen (Psi c 1);Psilocybe cubensis (fungus) cyclophilin (Psi c 2);Coprinus comatus (shaggy cap) antigen (Cop c 1);Coprinus comatus (shaggy cap) antigen (Cop c 2);Coprinus comatus (shaggy cap) antigen (Cop c 3);Coprinus comatus (shaggy cap) antigen (Cop c 5);Coprinus comatus (shaggy cap) antigen (Cop c 7);Aedes aegyptii (mosquito) apyrase (Aed a 1);Aedes aegyptii (mosquito) antigen (Aed a 2);Apis mellifera (honey bee) phospholipase A2 (Api m 1);Apis mellifera (honey bee) hyaluronidase (Api m 2);Apis mellifera (honey bee) melittin (Api m 4);Apis mellifera (honey bee) antigen (Api m 6);Bombus pennsylvanicus (bumble bee) phospholipase (Bom p 1);Bombus pennsylvanicus (bumble bee) protease (Bom p 4);Blattella germanica (German cockroach) Bd90k (Bla g 1);Blattella germanica (German cockroach) aspartic protease (Bla g 2);Blattella germanica (German cockroach) calycin (Bla g 4);Blattella germanica (German cockroach) glutathione transferase (Bla g 5);Blattella germanica (German cockroach) troponin C (Bla g 6);Periplaneta americana (American cockroach) Cr-PII (Per a 1);Periplaneta americana (American cockroach) Cr-PI (Per a 3);Periplaneta americana (American cockroach) tropomyosin (Per a 7);Chironomus thummi thummi (midge) hemoglobin (Chi t 1-9);Chironomus thummi thummi (midge) component III (Chi t 1.01);Chironomus thummi thummi (midge) component IV (Chi t 1.02);Chironomus thummi thummi (midge) component I (Chi t 2.0101);Chironomus thummi thummi (midge) component IA (Chi t 2.0102);Chironomus thummi thummi (midge) component II-beta (Chi t 3);Chironomus thummi thummi (midge) component IIIA (Chi t 4);Chironomus thummi thummi (midge) component VI (Chi t 5);Chironomus thummi thummi (midge) component VIIA (Chi t 6.01);Chironomus thummi thummi (midge) component IX (Chi t 6.02);Chironomus thummi thummi (midge) component VIIB (Chi t 7);Chironomus thummi thummi (midge) component VIII (Chi t 8);Chironomus thummi thummi (midge) component X (Chi t 9);Dolichovespula maculata (white face hornet) phospholipase (Dol m 1);Dolichovespula maculata (white face hornet) hyaluronidase (Dol m 2);Dolichovespula maculata (white face hornet) antigen 5 (Dol m 5);Dolichovespula arenaria (yellow hornet) antigen 5 (Dol a 5);Polistes annularies (wasp) phospholipase A1 (Pol a 1);Polistes annularies (wasp) hyaluronidase (Pol a 2);Polistes annularies (wasp) antigen 5 (Pol a 5);Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 1);Polistes dominulus (Mediterranean paper wasp) serine protease (Pol d 4);Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 5);Polistes exclamans (wasp) phospholipase A1 (Pol e 1);Polistes exclamans (wasp) antigen 5 (Pol e 5);Polistes fuscatus (wasp) antigen 5 (Pol f 5);Polistes metricus (wasp) antigen 5 (Pol m 5);Vespa crabo (European hornet) phospholipase (Vesp c 1);Vespa crabo (European hornet) antigen 5 (Vesp c 5.0101);Vespa crabo (European hornet) antigen 5 (Vesp c 5.0102);Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.01);Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.02);Vespa mandarina (giant Asian hornet) antigen (Vesp m 5);Vespula flavopilosa (yellowjacket) antigen 5 (Ves f 5);Vespula germanica (yellowjacket) antigen 5 (Ves g 5);Vespula maculifrons (yellowjacket) phospholipase A1 (Ves m 1);Vespula maculifrons (yellowjacket) hyaluronidase (Ves m 2);Vespula maculifrons (yellowjacket) antigen 5 (Ves m 5);Vespula pennsylvanica (yellowjacket) (antigen 5Ves p 5);Vespula squamosa (yellowjacket) antigen 5 (Ves s 5);Vespula vidua (wasp) antigen (Ves vi 5);Vespula vulgaris (yellowjacket) phospholipase A1 (Ves v 1);Vespula vulgaris (yellowjacket) hyaluronidase (Ves v 2);Vespula vulgaris (yellowjacket) antigen 5 (Ves v 5);Myrmecia pilosula (Australian jumper ant) antigen (Myr p 1);Myrmecia pilosula (Australian jumper ant) antigen (Myr p 2);Solenopsis geminata (tropical fire ant) antigen (Sol g 2);Solenopsis geminata (tropical fire ant) antigen (Sol g 4);Solenopsis invicta (fire ant) antigen (Sol i 2);Solenopsis invicta (fire ant) antigen (Sol i 3);Solenopsis invicta (fire ant) antigen (Sol i 4);Solenopsis saevissima (Brazilian fire ant) antigen (Sol s 2);Gadus callarias (cod) allergen M (Gad c 1);Salmo salar (Atlantic salmon) parvalbumin (Sal s 1);Gallus domesticus (chicken) ovomucoid (Gal d 1);Gallus domesticus (chicken) ovalbumin (Gal d 2);Gallus domesticus (chicken) conalbumin; A22 (Gal d 3);Gallus domesticus (chicken) lysozyme (Gal d 4);Gallus domesticus (chicken) serum albumin (Gal d 5);Metapenaeus ensis (shrimp) tropomyosin (Met e 1);Penaeus aztecus (shrimp) tropomyosin (Pen a 1);Penaeus indicus (shrimp) tropomyosin (Pen i 1);Todarodes pacificus (squid) tropomyosin (Tod p 1);Haliotis Midae (abalone) antigen (Hal m 1);Apium graveolens (celery) Bet v 1 homologue (Api g 1);Apium graveolens (celery) profilin (Api g 4);Apium graveolens (celery) antigen (Api g 5);Brassica juncea (oriental mustard) 2S albumin (Bra j 1);Brassica rapa (turnip) prohevein-like protein (Bar r 2);Hordeum vulgare (barley) BMAI-1 (Hor v 1);Zea mays (maize, corn) lipid transfer protein (Zea m 14);Corylus avellana (hazelnut) Bet v 1 homologue (Cor a 1.0401);Malus domestica (apple) Bet v 1 homologue (Mal d 1);Malus domestica (apple) lipid transfer protein (Mal d 3);Pyrus communis (pear) Bet v 1 homologue (Pyr c 1);Pyrus communis (pear) profilin (Pyr c 4);Pyrus communis (pear) isoflavone reductase homologue (Pyr c 5);Oryza sativa (rice) antigen (Ory s 1);Persea americana (avocado) endochitinase (Pers a 1);Prunus armeniaca (apricot) Bet v 1 homologue (Pru ar 1);Prunus armeniaca (apricot) lipid transfer protein (Pru ar 3);Prunus avium (sweet cherry) Bet v 1 homologue (Pru av 1);Prunus avium (sweet cherry) thaumatin homologue (Pru av 2);Prunus avium (sweet cherry) profilin (Pru av 4);Prunus persica (peach) lipid transfer protein (Pru p 3);Sinapis alba (yellow mustard) 2S albumin (Sin a 1);Glycine max (soybean) HPS (Gly m 1.0101);Glycine max (soybean) HPS (Gly m 1.0102);Glycine max (soybean) antigen (Gly m 2);Glycine max (soybean) profilin (Gly m 3);Arachis hypogaea (peanut) vicilin (Ar a h 1);Arachis hypogaea (peanut) (conglutin Ar a h 2);Arachis hypogaea (peanut) glycinin (Ar a h 3);Arachis hypogaea (peanut) glycinin (Ar a h 4);Arachis hypogaea (peanut) (profilin Ar a h 5);Arachis hypogaea (peanut) conglutin homologue (Ar a h 6);Arachis hypogaea (peanut) conglutin homologue (Ar a h 7);Actinidia chinensis (kiwi) cysteine protease (Act c 1);Solanum tuberosum (potato) patatin (Sol t 1);Bertholletia excelsa (Brazil nut) 2S albumin (Ber e 1);Juglans regia (English walnut) 2S albumin (Jug r 1);Juglans regia (English walnut) vicilin (Jug r 2);Ricinus communis (castor bean) 2S albumin (Ric c 1);Anisakis simplex (nematode) antigen (Ani s 1);Anisakis simplex (nematode) paramyosin (Ani s 2);Ascaris suum (worm) antigen (Asc s 1);Aedes aegyptii (mosquito) apyrase (Aed a 1);Aedes aegyptii (mosquito) antigen (Aed a 2);Hevea brasiliensis (rubber) elongation factor (Hev b 1);Hevea brasiliensis (rubber) 1,3-glucanase (Hev b 2);Hevea brasiliensis (rubber) antigen (Hev b 3);Hevea brasiliensis (rubber) component of microhelix protein complex (Hev b 4);Hevea brasiliensis (rubber) antigen (Hev b 5);Hevea brasiliensis (rubber) hevein precursor (Hev b 6.01);Hevea brasiliensis (rubber) hevein (Hev b 6.02);Hevea brasiliensis (rubber) C-terminal fragment antigen (Hev b 6.03);Hevea brasiliensis (rubber) patatin homologue (Hev b 7);Hevea brasiliensis (rubber) profilin (Hev b 8);Hevea brasiliensis (rubber) enolase (Hev b 9);Hevea brasiliensis (rubber) Mn-superoxide dismut (Hev b 10);Ctenocephalides felis felis (cat flea) antigen (Cte f 1);Homo sapiens (human autoallergen) antigen (Hom s 1);Homo sapiens (human autoallergen) antigen (Hom s 2);Homo sapiens (human autoallergen) antigen (Hom s 3);Homo sapiens (human autoallergen) antigen (Hom s 4); andHomo sapiens (human autoallergen) antigen (Hom s 5), the expressed protein allergen being encapsulated within the dead E. coli; and a pharmaceutically acceptable carrier, wherein the administered dead E. coli are taken up by antigen presenting cells in the subject, the recombinant version of the allergen protein is released and processed inside the antigen presenting cells, and the processed protein is displayed on the antigen presenting cell surface, so that one or more symptoms of the subject's allergy to the protein allergen is reduced or decreased. 3. A method of treating allergy in a subject susceptible to an allergic response to a protein allergen, the method comprising a step of: administering to a subject, via the subject's rectum, a composition comprising: dead E. coli that has expressed non-secreted version of a protein allergen selected from the group consisting of:Ambrosia artemisiifolia (short ragweed) antigen E (Amb a 1);Ambrosia artemisiifolia (short ragweed) antigen K (Amb a 2);Ambrosia artemisiifolia (short ragweed) Ra3 antigen (Amb a 3);Ambrosia artemisiifolia (short ragweed) Ra5 antigen (Amb a 5);Ambrosia artemisiifolia (short ragweed) Ra6 antigen (Amb a 6);Ambrosia artemisiifolia (short ragweed) Ra7 antigen (Amb a 7);Ambrosia trifida (giant ragweed) Ra5G antigen (Amb t 5);Artemisia vulgaris (mugwort) antigen (Art v 1);Artemisia vulgaris (mugwort) antigen (Art v 2);Helianthus annuus (sunflower) antigen (Hel a 1);Helianthus annuus (sunflower) profilin (Hel a 2);Mercurialis annua (annual mercury) profilin (Mer a 1);Cynodon dactylon (Bermuda grass) antigen (Cyn d 1);Cynodon dactylon (Bermuda grass) antigen (Cyn d 7);Cynodon dactylon (Bermuda grass) profilin (Cyn d 12);Dactylis glomerata (orchard grass) AgDg1 antigen (Dac g 1);Dactylis glomerata (orchard grass) antigen (Dac g 2);Dactylis glomerata (orchard grass) antigen (Dac g 3);Dactylis glomerata (orchard grass) antigen (Dac g 5);Holcus lanatus (velvet grass) antigen (Hol l 1);Lolium perenne (rye grass) group I antigen (Lol p 1);Lolium perenne (rye grass) group II antigen (Lol p 2);Lolium perenne (rye grass) group III antigen (Lol p 3);Lolium perenne (rye grass) group IX antigen (Lol p 5);Lolium perenne (rye grass) antigen (Lol p Ib);Lolium perenne (rye grass) trypsin (Lol p 11);Phalaris aquatica (canary grass) antigen (Pha a 1);Phleum pratense (timothy grass) antigen (Phl p 1);Phleum pratense (timothy grass) antigen (Phl p 2);Phleum pratense (timothy grass) antigen (Phl p 4);Phleum pratense (timothy grass) antigen Ag 25 (Phl p 5);Phleum pratense (timothy grass) antigen (Phl p 6);Phleum pratense (timothy grass) profilin (Phl p 12);Phleum pratense (timothy grass) polygalacturonase (Phl p 13);Poa pratensis (Kentucky blue grass) group I antigen (Poa p 1);Poa pratensis (Kentucky blue grass) antigen (Poa p 5);Sorghum halepense (Johnson grass) antigen (Sor h 1);Alnus glutinosa (alder) antigen (Aln g 1);Betula verrucosa (birch) antigen (Bet v 1);Betula verrucosa (birch) profilin (Bet v 2);Betula verrucosa (birch) antigen (Bet v 3);Betula verrucosa (birch) antigen (Bet v 4);Betula verrucosa (birch) isoflavone reductase homologue (Bet v 5);Betula verrucosa (birch) cyclophilin (Bet v 7);Carpinus betulus (hornbeam) antigen (Car b 1);Castanea sativa (chestnut) Bet v 1 homologue (Cas s 1);Castanea sativa (chestnut) chitinase (Cas s 5);Corylus avelana (hazel) antigen (Cor a 1);Quercus alba (white oak) antigen (Que a 1);Cryptomeria japonica (sugi) antigen (Cry j 1);Cryptomeria japonica (sugi) antigen (Cry j 2);Juniperus ashei (mountain cedar) antigen (Jun a 1);Juniperus ashei (mountain cedar) antigen (Jun a 3);Juniperus oxycedrus (prickly juniper) calmodulin-like antigen (Jun o 2);Juniperus sabinoides (mountain cedar) antigen (Jun s 1);Juniperus virginiana (eastern red cedar) antigen (Jun v 1);Fraxinus excelsior (ash) antigen (Fra e 1);Ligustrum vulgare (privet) antigen (Lig v 1);Olea europea (olive) antigen (Ole e 1);Olea europea (olive) profilin (Ole e 2);Olea europea (olive) antigen (Ole e 3);Olea europea (olive) antigen (Ole e 4);Olea europea (olive) superoxide dismutase (Ole e 5);Olea europea (olive) antigen (Ole e 6);Syringa vulgaris (lilac) antigen (Syr v 1);Acarus siro (mite) fatty acid-binding protein (Aca s 13);Blomia tropicalis (mite) antigen (Blo t 5);Blomia tropicalis (mite) Bt11a antigen (Blo t 12);Blomia tropicalis (mite) Bt6 fatty acid-binding protein (Blo t);Dermatophagoides pteronyssinus (mite) antigen P1 (Der p 1);Dermatophagoides pteronyssinus (mite) antigen (Der p 2);Dermatophagoides pteronyssinus (mite) trypsin (Der p 3);Dermatophagoides pteronyssinus (mite) amylase (Der p 4);Dermatophagoides pteronyssinus (mite) antigen (Der p 5);Dermatophagoides pteronyssinus (mite) chymotrypsin (Der p 6);Dermatophagoides pteronyssinus (mite) antigen (Der p 7);Dermatophagoides pteronyssinus (mite) glutathione transferase (Der p 8);Dermatophagoides pteronyssinus (mite) collagenolytic serine prot. (Der p 9);Dermatophagoides pteronyssinus (mite) tropomyosin (Der p 10);Dermatophagoides pteronyssinus (mite) apolipophorin like p (Der p 14);Dermatophagoides microceras (mite) antigen (Der m 1);Dermatophagoides farinae (mite) antigen (Der f 1);Dermatophagoides farinae (mite) antigen (Der f 2);Dermatophagoides farinae (mite) antigen (Der f 3);Dermatophagoides farinae (mite) tropomyosin (Der f 10);Dermatophagoides farinae (mite) paramyosin (Der f 11);Dermatophagoides farinae (mite) Mag 3, apolipophorin (Der f 14);Euroglyphus maynei (mite) apolipophorin (Eur m 14);Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0101);Lepidoglyphus destructor (storage mite) antigen (Lep d 2.0102);Bos domesticus (cow) Ag3, lipocalin (Bos d 2);Bos domesticus (cow) alpha-lactalbumin (Bos d 4);Bos domesticus (cow) beta-lactalbumin (Bos d 5);Bos domesticus (cow) serum albumin (Bos d 6);Bos domesticus (cow) immunoglobulin (Bos d 7);Bos domesticus (cow) casein (Bos d 8);Canis familiaris (dog) antigen (Can f 1);Canis familiaris (dog) antigen (Can f 2);Canis familiaris (dog) albumin (Can f ?);Equus caballus (horse) lipocalin (Equ c 1);Equus caballus (horse) lipocalin (Equ c 2);Felis domesticus (cat) cat-1 antigen (Fel d 1);Mus musculus (mouse) MUP antigen (Mus m 1);Rattus norvegius (rat) antigen (Rat n 1);Alternaria alternata (fungus) antigen (Alt a 1);Alternaria alternata (fungus) antigen (Alt a 2);Alternaria alternata (fungus) heat shock protein (Alt a 3);Alternaria alternata (fungus) ribosomal protein (Alt a 6);Alternaria alternata (fungus) YCP4 protein (Alt a 7);Alternaria alternata (fungus) aldehyde dehydrogenase (Alt a 10);Alternaria alternata (fungus) enloase (Alt a 11);Alternaria alternata (fungus) acid ribosomal protein P1 (Alt a 12);Cladosporium herbarum (fungus) antigen (Cla h 1);Cladosporium herbarum (fungus) antigen (Cla h 2);Cladosporium herbarum (fungus) aldehyde dehydrogenase (Cla h 3);Cladosporium herbarum (fungus) ribosomal protein);Cladosporium herbarum (fungus) YCP4 protein (Cla h 5);Cladosporium herbarum (fungus) enolase (Cla h 6);Cladosporium herbarum (fungus) acid ribosomal protein P1 (Cla h 12);Aspergillus flavus (fungus) alkaline serine proteinase (Asp fl 13);Aspergillus Fumigatus (fungus) antigen (Asp f 1);Aspergillus Fumigatus (fungus) antigen (Asp f 2);Aspergillus Fumigatus (fungus) peroxisomal protein (Asp f 3);Aspergillus Fumigatus (fungus) antigen (Asp f 4);Aspergillus Fumigatus (fungus) metalloprotease (Asp f 5);Aspergillus Fumigatus (fungus) Mn superoxide dismutase (Asp f 6);Aspergillus Fumigatus (fungus) antigen (Asp f 7);Aspergillus Fumigatus (fungus) ribosomal protein P2 (Asp f 8);Aspergillus Fumigatus (fungus) antigen (Asp f 9);Aspergillus Fumigatus (fungus) aspartis protease (Asp f 10);Aspergillus Fumigatus (fungus) peptidyl-prolyl isomerase (Asp f 11);Aspergillus Fumigatus (fungus) heat shock protein P70 (Asp f 12);Aspergillus Fumigatus (fungus) alkaline serine proteinase (Asp f 13);Aspergillus Fumigatus (fungus) antigen (Asp f 15);Aspergillus Fumigatus (fungus) antigen (Asp f 16);Aspergillus Fumigatus (fungus) antigen (Asp f 17);Aspergillus Fumigatus (fungus) vacuolar serine (Asp f 18);Aspergillus niger (fungus) beta-xylosidase (Asp n 14);Aspergillus niger (fungus) antigen (Asp n 18);Aspergillus niger (fungus) vacuolar serine proteinase;Aspergillus oryzae (fungus) TAKA-amylase A (Asp o 2);Aspergillus oryzae (fungus) alkaline serine proteinase (Asp o 13);Penicillium brevicompactum (fungus) alkaline serine proteinase (Pen b 13);Penicillium citrinum (fungus) heat shock protein P70 (Pen c 1);Penicillium citrinum (fungus) peroxisomal membrane protein (Pen c 3);Penicillium citrinum (fungus) alkaline serine proteinase (Pen c 13);Penicillium notatum (fungus) N-acetyl glucosaminidase (Pen n 1);Penicillium notatum (fungus) alkaline serine proteinase (Pen n 13);Penicillium notatum (fungus) vacuolar serine proteinase (Pen n 18);Penicillium oxalicum (fungus) vacuolar serine proteinase (Pen o 18);Trichophyton rubrum (fungus) antigen (Tri r 2);Trichophyton rubrum (fungus) serine protease (Tri r 4);Trichophyton tonsurans (fungus) antigen (Tri t 1);Trichophyton tonsurans (fungus) serine protease (Tri t 4);Candida albicans (fungus) antigen (Cand a 1);Candida boidinii (fungus) antigen (Cand b 2);Malassezia furfur (fungus) antigen (Mal f 1);Malassezia furfur (fungus) MF1 peroxisomal membrane protein (Mal f 2);Malassezia furfur (fungus) MF2 peroxisomal membrane protein (Mal f 3);Malassezia furfur (fungus) antigen (Mal f 4);Malassezia furfur (fungus) antigen (Mal f 5);Malassezia furfur (fungus) cyclophilin homologue (Mal f 6);Psilocybe cubensis (fungus) antigen (Psi c 1);Psilocybe cubensis (fungus) cyclophilin (Psi c 2);Coprinus comatus (shaggy cap) antigen (Cop c 1);Coprinus comatus (shaggy cap) antigen (Cop c 2);Coprinus comatus (shaggy cap) antigen (Cop c 3);Coprinus comatus (shaggy cap) antigen (Cop c 5);Coprinus comatus (shaggy cap) antigen (Cop c 7);Aedes aegyptii (mosquito) apyrase (Aed a 1);Aedes aegyptii (mosquito) antigen (Aed a 2);Apis mellifera (honey bee) phospholipase A2 (Api m 1);Apis mellifera (honey bee) hyaluronidase (Api m 2);Apis mellifera (honey bee) melittin (Api m 4);Apis mellifera (honey bee) antigen (Api m 6);Bombus pennsylvanicus (bumble bee) phospholipase (Bom p 1);Bombus pennsylvanicus (bumble bee) protease (Bom p 4);Blattella germanica (German cockroach) Bd90k (Bla g 1);Blattella germanica (German cockroach) aspartic protease (Bla g 2);Blattella germanica (German cockroach) calycin (Bla g 4);Blattella germanica (German cockroach) glutathione transferase (Bla g 5);Blattella germanica (German cockroach) troponin C (Bla g 6);Periplaneta americana (American cockroach) Cr-PII (Per a 1);Periplaneta americana (American cockroach) Cr-PI (Per a 3);Periplaneta americana (American cockroach) tropomyosin (Per a 7);Chironomus thummi thummi (midge) hemoglobin (Chi t 1-9);Chironomus thummi thummi (midge) component III (Chi t 1.01);Chironomus thummi thummi (midge) component IV (Chi t 1.02);Chironomus thummi thummi (midge) component I (Chi t 2.0101);Chironomus thummi thummi (midge) component IA (Chi t 2.0102);Chironomus thummi thummi (midge) component II-beta (Chi t 3);Chironomus thummi thummi (midge) component IIIA (Chi t 4);Chironomus thummi thummi (midge) component VI (Chi t 5);Chironomus thummi thummi (midge) component VIIA (Chi t 6.01);Chironomus thummi thummi (midge) component IX (Chi t 6.02);Chironomus thummi thummi (midge) component VIIB (Chi t 7);Chironomus thummi thummi (midge) component VIII (Chi t 8);Chironomus thummi thummi (midge) component X (Chi t 9);Dolichovespula maculata (white face hornet) phospholipase (Dol m 1);Dolichovespula maculata (white face hornet) hyaluronidase (Dol m 2);Dolichovespula maculata (white face hornet) antigen 5 (Dol m 5);Dolichovespula arenaria (yellow hornet) antigen 5 (Dol a 5);Polistes annularies (wasp) phospholipase A1 (Pol a 1);Polistes annularies (wasp) hyaluronidase (Pol a 2);Polistes annularies (wasp) antigen 5 (Pol a 5);Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 1);Polistes dominulus (Mediterranean paper wasp) serine protease (Pol d 4);Polistes dominulus (Mediterranean paper wasp) antigen (Pol d 5);Polistes exclamans (wasp) phospholipase A1 (Pol e 1);Polistes exclamans (wasp) antigen 5 (Pol e 5);Polistes fuscatus (wasp) antigen 5 (Pol f 5);Polistes metricus (wasp) antigen 5 (Pol m 5);Vespa crabo (European hornet) phospholipase (Vesp c 1);Vespa crabo (European hornet) antigen 5 (Vesp c 5.0101);Vespa crabo (European hornet) antigen 5 (Vesp c 5.0102);Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.01);Vespa mandarina (giant Asian hornet) antigen (Vesp m 1.02);Vespa mandarina (giant Asian hornet) antigen (Vesp m 5);Vespula flavopilosa (yellowjacket) antigen 5 (Ves f 5);Vespula germanica (yellowjacket) antigen 5 (Ves g 5);Vespula maculifrons (yellowjacket) phospholipase A1 (Ves m 1);Vespula maculifrons (yellowjacket) hyaluronidase (Ves m 2);Vespula maculifrons (yellowjacket) antigen 5 (Ves m 5);Vespula pennsylvanica (yellowjacket) (antigen 5Ves p 5);Vespula squamosa (yellowjacket) antigen 5 (Ves s 5);Vespula vidua (wasp) antigen (Ves vi 5);Vespula vulgaris (yellowjacket) phospholipase A1 (Ves v 1);Vespula vulgaris (yellowjacket) hyaluronidase (Ves v 2);Vespula vulgaris (yellowjacket) antigen 5 (Ves v 5);Myrmecia pilosula (Australian jumper ant) antigen (Myr p 1);Myrmecia pilosula (Australian jumper ant) antigen (Myr p 2);Solenopsis geminata (tropical fire ant) antigen (Sol g 2);Solenopsis geminata (tropical fire ant) antigen (Sol g 4);Solenopsis invicta (fire ant) antigen (Sol i 2);Solenopsis invicta (fire ant) antigen (Sol i 3);Solenopsis invicta (fire ant) antigen (Sol i 4);Solenopsis saevissima (Brazilian fire ant) antigen (Sol s 2);Gadus callarias (cod) allergen M (Gad c 1);Salmo salar (Atlantic salmon) parvalbumin (Sal s 1);Gallus domesticus (chicken) ovomucoid (Gal d 1);Gallus domesticus (chicken) ovalbumin (Gal d 2);Gallus domesticus (chicken) conalbumin; A22 (Gal d 3);Gallus domesticus (chicken) lysozyme (Gal d 4);Gallus domesticus (chicken) serum albumin (Gal d 5);Metapenaeus ensis (shrimp) tropomyosin (Met e 1);Penaeus aztecus (shrimp) tropomyosin (Pen a 1);Penaeus indicus (shrimp) tropomyosin (Pen i 1);Todarodes pacificus (squid) tropomyosin (Tod p 1);Haliotis Midae (abalone) antigen (Hal m 1);Apium graveolens (celery) Bet v 1 homologue (Api g 1);Apium graveolens (celery) profilin (Api g 4);Apium graveolens (celery) antigen (Api g 5);Brassica juncea (oriental mustard) 2S albumin (Bra j 1);Brassica rapa (turnip) prohevein-like protein (Bar r 2);Hordeum vulgare (barley) BMAI-1 (Hor v 1);Zea mays (maize, corn) lipid transfer protein (Zea m 14);Corylus avellana (hazelnut) Bet v 1 homologue (Cor a 1.0401);Malus domestica (apple) Bet v 1 homologue (Mal d 1);Malus domestica (apple) lipid transfer protein (Mal d 3);Pyrus communis (pear) Bet v 1 homologue (Pyr c 1);Pyrus communis (pear) profilin (Pyr c 4);Pyrus communis (pear) isoflavone reductase homologue (Pyr c 5);Oryza sativa (rice) antigen (Ory s 1);Persea americana (avocado) endochitinase (Pers a 1);Prunus armeniaca (apricot) Bet v 1 homologue (Pru ar 1);Prunus armeniaca (apricot) lipid transfer protein (Pru ar 3);Prunus avium (sweet cherry) Bet v 1 homologue (Pru av 1);Prunus avium (sweet cherry) thaumatin homologue (Pru av 2);Prunus avium (sweet cherry) profilin (Pru av 4);Prunus persica (peach) lipid transfer protein (Pru p 3);Sinapis alba (yellow mustard) 2S albumin (Sin a 1);Glycine max (soybean) HPS (Gly m 1.0101);Glycine max (soybean) HPS (Gly m 1.0102);Glycine max (soybean) antigen (Gly m 2);Glycine max (soybean) profilin (Gly m 3);Arachis hypogaea (peanut) vicilin (Ar a h 1);Arachis hypogaea (peanut) (conglutin Ar a h 2);Arachis hypogaea (peanut) glycinin (Ar a h 3);Arachis hypogaea (peanut) glycinin (Ar a h 4);Arachis hypogaea (peanut) (profilin Ar a h 5);Arachis hypogaea (peanut) conglutin homologue (Ar a h 6);Arachis hypogaea (peanut) conglutin homologue (Ar a h 7);Actinidia chinensis (kiwi) cysteine protease (Act c 1);Solanum tuberosum (potato) patatin (Sol t 1);Bertholletia excelsa (Brazil nut) 2S albumin (Ber e 1);Juglans regia (English walnut) 2S albumin (Jug r 1);Juglans regia (English walnut) vicilin (Jug r 2);Ricinus communis (castor bean) 2S albumin (Ric c 1);Anisakis simplex (nematode) antigen (Ani s 1);Anisakis simplex (nematode) paramyosin (Ani s 2);Ascaris suum (worm) antigen (Asc s 1);Aedes aegyptii (mosquito) apyrase (Aed a 1);Aedes aegyptii (mosquito) antigen (Aed a 2);Hevea brasiliensis (rubber) elongation factor (Hev b 1);Hevea brasiliensis (rubber) 1,3-glucanase (Hev b 2);Hevea brasiliensis (rubber) antigen (Hev b 3);Hevea brasiliensis (rubber) component of microhelix protein complex (Hev b 4);Hevea brasiliensis (rubber) antigen (Hev b 5);Hevea brasiliensis (rubber) hevein precursor (Hev b 6.01);Hevea brasiliensis (rubber) hevein (Hev b 6.02);Hevea brasiliensis (rubber) C-terminal fragment antigen (Hev b 6.03);Hevea brasiliensis (rubber) patatin homologue (Hev b 7);Hevea brasiliensis (rubber) profilin (Hev b 8);Hevea brasiliensis (rubber) enolase (Hev b 9);Hevea brasiliensis (rubber) Mn-superoxide dismut (Hev b 10);Ctenocephalides felis felis (cat flea) antigen (Cte f 1);Homo sapiens (human autoallergen) antigen (Hom s 1);Homo sapiens (human autoallergen) antigen (Hom s 2);Homo sapiens (human autoallergen) antigen (Hom s 3);Homo sapiens (human autoallergen) antigen (Hom s 4); andHomo sapiens (human autoallergen) antigen (Hom s 5), the expressed protein allergen being encapsulated within the dead E. coli; and a pharmaceutically acceptable carrier, so that one or more symptoms of the subject's allergy to the protein allergen is reduced or decreased. 4. A method of treating peanut allergy in a subject susceptible to an allergic response to a protein allergen, the method comprising a step of: administering to a subject, via the subject's rectum, a composition comprising: dead E. coli that has expressed a protein allergen selected from the group consisting of peanut allergens Ara h 1, Ara h 2, and Ara h 3, the expressed protein allergen being encapsulated within the dead E. coli; anda pharmaceutically acceptable carrier, wherein the administered dead E. coli are taken up by antigen presenting cells in the subject, the recombinant version of the peanut allergen is released and processed inside the antigen presenting cells, and the processed allergen is displayed on the antigen presenting cell surface, so that one or more symptoms of the subject's allergy to the protein allergen is reduced or decreased. 5. A method of treating peanut allergy in a subject susceptible to an allergic response to a protein allergen, the method comprising a step of: administering to a subject, via the subject's rectum, a composition comprising: dead E. coli that has expressed a non-secreted version of a protein allergen selected from the group consisting of peanut allergens Ara h 1, Ara h 2, and Ara h 3, the expressed protein allergen being encapsulated within the dead E. coli; anda pharmaceutically acceptable carrier, so that one or more symptoms of the subject's allergy to the protein allergen is reduced or decreased. 6. The method of any one of claims 1, 2 and 3, wherein the subject is a mammal. 7. The method of any one of claims 1, 2 and 3, wherein the subject is a human. 8. The method of any one of claims 1, 2 and 3, wherein in the step of administering, the composition is delivered in the form of a suppository. 9. The method of any one of claims 1, 2 and 3, wherein in the step of administering, the composition is delivered in the form of an enema. 10. The method of any one of claims 1, 2 and 3, wherein in the step of administering, the composition is delivered using a rectal catheter. 11. The method of any one of claims 1, 2 and 3, further comprising a step of identifying a subject susceptible to an allergic response to a protein allergen, wherein the subject is identified as an individual with an elevated level of IgE antibodies that bind with the protein allergen, and wherein the step of administering comprises administering to the identified subject. 12. The method of any one of claims 1, 2 and 3, further comprising a step of identifying a subject susceptible to an allergic response to a protein allergen, wherein the subject is identified as an individual with a positive skin prick test to the protein allergen, and wherein the step of administering comprises administering to the identified subject. 13. The method of any one of claims 1, 2 and 3, further comprising a step of identifying a subject susceptible to an allergic response to a protein allergen, wherein the subject is identified as an individual having a characteristic selected from the group consisting of a prior display of allergic symptoms when exposed to the protein allergen and a familial relationship with an individual who previously displayed allergic symptoms when exposed to the protein allergen, and wherein the step of administering comprises administering to the identified subject. 14. A method of treating peanut allergy in a subject susceptible to an allergic response to a protein allergen selected from the group consisting of peanut allergens Ara h 1, Ara h 2, and Ara h 3, the method comprising: administering to a subject, via the subject's rectum, a composition comprising: dead E. coli cells having expressed a peanut allergen selected from the group consisting of Ara h1 of SEQ ID NO: 2, Ara h2 of SEQ ID NO: 4 and Ara h3 of SEQ ID NO: 6 so that the expressed allergen is encapsulated within the dead E. coli cells and is not exposed to the subject's IgE antibodies during administration; anda pharmaceutically acceptable carrier, so that one or more symptoms of the subject's allergy to the protein allergen is reduced or decreased. 15. The method of any one of claims 4, 5 and 14, wherein the protein allergen is a modified peanut allergen protein whose amino acid sequence differs from that of an intact wild-type peanut allergen protein in that at least one IgE epitope has a substitution in the modified peanut allergen protein such that the modified peanut allergen protein has a reduced ability to bind to or cross-link IgE as compared with the unmodified peanut allergen protein, the at least one IgE epitope being one that is recognized when the unmodified peanut allergen protein is contacted with serum IgE from an individual that is allergic to the unmodified peanut allergen protein, wherein: when the wild-type peanut protein has the amino acid sequence of SEQ ID NO: 2, the substitution is in an IgE epitope selected from the group consisting of: an epitope found between amino acids 25 and 34 of SEQ ID NO: 2;an epitope found between amino acids 48 and 57 of SEQ ID NO: 2;an epitope found between amino acids 65 and 74 of SEQ ID NO: 2;an epitope found between amino acids 89 and 98 of SEQ ID NO: 2;an epitope found between amino acids 97 and 106 of SEQ ID NO: 2;an epitope found between amino acids 107 and 116 of SEQ ID NO: 2;an epitope found between amino acids 123 and 132 of SEQ ID NO: 2;an epitope found between amino acids 134 and 143 of SEQ ID NO: 2;an epitope found between amino acids 294 and 303 of SEQ ID NO: 2;an epitope found between amino acids 311 and 320 of SEQ ID NO: 2;an epitope found between amino acids 325 and 334 of SEQ ID NO: 2;an epitope found between amino acids 344 and 353 of SEQ ID NO: 2;an epitope found between amino acids 393 and 402 of SEQ ID NO: 2;an epitope found between amino acids 409 and 418 of SEQ ID NO: 2;an epitope found between amino acids 461 and 470 of SEQ ID NO: 2;an epitope found between amino acids 498 and 507 of SEQ ID NO: 2;an epitope found between amino acids 525 and 534 of SEQ ID NO: 2;an epitope found between amino acids 539 and 548 of SEQ ID NO: 2;an epitope found between amino acids 551 and 560 of SEQ ID NO: 2;an epitope found between amino acids 559 and 568 of SEQ ID NO: 2;an epitope found between amino acids 578 and 587 of SEQ ID NO: 2;an epitope found between amino acids 597 and 606 of SEQ ID NO: 2;and a combination thereof; andwhen the wild-type peanut protein has the amino acid sequence of SEQ ID NO: 4, the substitution is in an IgE epitope selected from the group consisting of: an epitope found between amino acids 15 and 24 of SEQ ID NO: 4;an epitope found between amino acids 21 and 30 of SEQ ID NO: 4;an epitope found between amino acids 27 and 36 of SEQ ID NO: 4;an epitope found between amino acids 39 and 48 of SEQ ID NO: 4;an epitope found between amino acids 49 and 58 of SEQ ID NO: 4;an epitope found between amino acids 57 and 66 of SEQ ID NO: 4;an epitope found between amino acids 65 and 74 of SEQ ID NO: 4;an epitope found between amino acids 115 and 124 of SEQ ID NO: 4;an epitope found between amino acids 127 and 136 of SEQ ID NO: 4;an epitope found between amino acids 143 and 152 of SEQ ID NO: 4;and a combination thereof; andwhen the wild-type peanut protein has the amino acid sequence of SEQ ID NO: 6, the substitution is in an IgE epitope selected from the group consisting of: an epitope found between amino acids 33 and 47 of SEQ ID NO: 6;an epitope found between amino acids 240 and 254 of SEQ ID NO: 6;an epitope found between amino acids 279 and 293 of SEQ ID NO: 6;an epitope found between amino acids 303 and 317 of SEQ ID NO: 6;and a combination thereof. 16. The method of any one of claims 4, 5 and 14, wherein the subject is a mammal. 17. The method of any one of claims 4, 5 and 14, wherein the subject is a human. 18. The method of any one of claims 4, 5 and 14, wherein in the step of administering, the composition is delivered in the form of a suppository. 19. The method of any one of claims 4, 5 and 14, wherein in the step of administering, the composition is delivered in the form of an enema. 20. The method of any one of claims 4, 5 and 14, wherein in the step of administering, the composition is delivered using a rectal catheter. 21. The method of any one of claims 4, 5 and 14, further comprising a step of identifying a subject susceptible to an allergic response to a protein allergen, wherein the subject is identified as an individual with an elevated level of IgE antibodies that bind with the protein allergen, and wherein the step of administering comprises administering to the identified subject. 22. The method of any one of claims 4, 5 and 14, further comprising a step of identifying a subject susceptible to an allergic response to a protein allergen, wherein the subject is identified as an individual with a positive skin prick test to the protein allergen, and wherein the step of administering comprises administering to the identified subject. 23. The method of any one of claims 4, 5 and 14, further comprising a step of identifying a subject susceptible to an allergic response to a protein allergen, wherein the subject is identified as an individual having a characteristic selected from the group consisting of a prior display of allergic symptoms when exposed to the protein allergen and a familial relationship with an individual who previously displayed allergic symptoms when exposed to the protein allergen, and wherein the step of administering comprises administering to the identified subject. 24. The method of any one of claims 4, 5 and 14, wherein the protein allergen has an amino acid sequence that shows 100% identity with that of a wild-type allergen as it occurs in nature.
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