Biodegradable, non-toxic biological adhesive for use in abdominal surgery
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/10
A61K-031/718
A61K-031/715
A61K-031/70
A61K-033/30
출원번호
US-0507623
(2006-08-22)
등록번호
US-8252333
(2012-08-28)
발명자
/ 주소
Cueto-Garcia, Jorge
출원인 / 주소
Cueto-Garcia, Jorge
대리인 / 주소
Michal, Robert P.
인용정보
피인용 횟수 :
2인용 특허 :
15
초록▼
A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to prevent anastomosis of a surgical wound in the digestive system of a patient, and for affixing a prost
A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to prevent anastomosis of a surgical wound in the digestive system of a patient, and for affixing a prosthesis during a hernia operation.
대표청구항▼
1. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on t
1. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, and said dextrin dispersion contains 45-75 weight % solids, based on the total weight of the formulation, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, wherein said formulation protects and seals anastomosis and suture lines in internal body cavities, and having a resistance to humidity to provide temporary protection of the anastomosis from at least the 2nd to the 14th post-operative days. 2. An adhesive formulation according to claim 1, wherein said formulation consists essentially of said dextrin, said at least one adhesiveness modifier agent, and said at least one antibiotic. 3. An adhesive formulation according to claim 1, wherein said dispersion is a dispersion of said dextrin in water. 4. An adhesive formulation according to claim 1, wherein said formulation contains 90-96 weight % of said dispersion, based on the total weight of the formulation. 5. An adhesive formulation according to claim 1, wherein said dextrin dispersion has a solids content of 60-68%. 6. An adhesive formulation according to claim 1, wherein said dextrin dispersion has a viscosity of 12,000-18,000 cp. 7. An adhesive formulation according to claim 1, wherein said dextrin dispersion has a viscosity of 15,000-18,000 cp. 8. An adhesive formulation according to claim 1, wherein said dextrin is a maltodextrin. 9. An adhesive formulation according to claim 1, wherein said at least one adhesiveness modifier agent further comprises an additional insoluble metal oxide. 10. An adhesive formulation according to claim 1, wherein said at least one adhesiveness modifier agent further comprises a calcium, iron, titanium, zirconium, cobalt, or additional zinc compound. 11. An adhesive formulation according to claim 1, wherein said at least one antibiotic is kanamycin. 12. An adhesive formulation according to claim 1, wherein said formulation contains 0.1-1 weight % of said at least one antibiotic, based on the total weight of the formulation. 13. An adhesive formulation according to claim 12, wherein said formulation contains 0.2-0.5 weight % of said at least one antibiotic, based on the total weight of the formulation. 14. An adhesive formulation according to claim 12, wherein said at least one antibiotic is kanamycin. 15. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities comprising dextrin as a dispersion, and at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation protects and seals anastomosis and suture lines in internal body cavities. 16. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation heals a wound within at least one of the gastrointestinal, respiratory and urinary systems of a patient, and the adhesive formulation protects against dehiscences of anastomosis of at least one of the gastrointestinal, respiratory and urinary systems. 17. A non-toxic biological adhesive formulation for affixing a prosthesis in a patient during a hernia operation, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation affixes a prosthesis in a patient during a hernia operation. 18. A non-toxic biological adhesive formulation for occluding a fistula within a patient, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation occludes a fistula within a patient. 19. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation is biodegradable and metabolized products thereof are non-toxic. 20. A non-toxic biological, adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation is biodegradable and biocompatible. 21. A non-toxic biological adhesive formulation for temporarily protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % solids, wherein said dextrin dispersion as a pH of 8-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation is biologically degradable and provides temporary protection and sealing of anastomosis and suture lines from the 2nd to the 14th post-operative day. 22. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-73 weight % dextrin solids, wherein said dextrin dispersion has a pH of 3-9 and a viscosity of 12,000-25,000 cp, and wherein said formulation protects and seals anastomosis and suture lines in internal body cavities. 23. A non-toxic biological adhesive formulation for protecting and sealing anastomosis and suture lines in internal body cavities, said formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, based on the total weight of the formulation, and said dextrin dispersion contains 45-75 weight % dextrin solids, wherein said dextrin dispersion has a pH of 8-9 and a viscosity of 12,000-25000 cp, and wherein said formulation protects and seals an anastomosis and provides temporary protection of the anastomosis from the 2nd to the 14th post-operative days. 24. An adhesive formulation according to claim 17, wherein said formulation contains 8-19 weight % of said at least one adhesiveness modifier agent, based on the total weight of the formulation.
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이 특허에 인용된 특허 (15)
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