[특허]Methods, kits, and compositions for generating new hair follicles and growing hair

[미국특허] Methods, kits, and compositions for generating new hair follicles and growing hair 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/00
출원번호	US-0443122 (2007-09-27)
등록번호	US-8252749 (2012-08-28)
국제출원번호	PCT/US2007/020842 (2007-09-27)
§371/§102 date	20100126 (20100126)
국제공개번호	WO2008/042216 (2008-04-10)
발명자 / 주소	Steinberg, David Pojasek, Kevin Prouty, Stephen Cotsarelis, George Ito, Mayumi
출원인 / 주소	Follica, Inc.
대리인 / 주소	Clark & Elbing LLP
인용정보	피인용 횟수 : 4 인용 특허 : 20

초록

The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.

대표청구항 ▼

1. A method for stimulating a hair growth on the skin of a subject, said method comprising the steps of: (a) inducing reepithelialization of the skin of said subject; and(b) contacting the cells of said skin with a composition comprising from 0.001% to 0.1% (w/v) of a compound selected from the group consisting of: leflunomide, gefitinib, erlotinib, lapatinib, canertinib, vandetanib, CL-387785, PKI166, pelitinib, HKI-272, HKI-357, and the leflunomide metabolite A771726 in an amount sufficient to generate hair follicles or stimulate hair growth on said skin. 2. The method of claim 1, wherein step (a) is performed less than two weeks prior to step (b). 3. The method of claim 1, wherein said small molecule EGFR inhibitor is gefitinib. 4. The method of claim 1, wherein said small molecule EGFR inhibitor is erlotinib. 5. The method of claim 1, wherein said small molecule EGFR inhibitor is leflunomide. 6. The method of claim 1, wherein said small molecule EGFR inhibitor is the leflunomide metabolite A771726. 7. The method of claim 1, wherein said skin is the skin of the subject's scalp or eyebrow. 8. The method of claim 1, wherein said subject suffers from balding of the scalp. 9. The method of claim 1, wherein said contacting is performed during the night. 10. The method of claim 1, wherein said contacting is performed during the day. 11. The method of claim 1, wherein said subject suffers from androgenetic alopecia. 12. The method of claim 1, wherein said subject suffers from discoid lupus erythematosis. 13. The method of claim 1, wherein said subject suffers from congenital hypotrichosis. 14. The method of claim 1, wherein said subject suffers from lichen planopilaris. 15. The method of claim 1, wherein said subject suffers from scarring alopecia. 16. The method of claim 1, further comprising the step of administering to said subject an additional biologically active agent selected from an antihistamine, an anti-inflammatory, a retinoid, an anti-androgen, an immunosuppressant, a channel opener, an antibiotic, and an antimicrobial. 17. The method of claim 1, wherein said small molecule EGFR inhibitor is administered to said subject once or twice daily.

이 특허에 인용된 특허 (20) 인용/피인용 타임라인 분석

Schnur Rodney Caughren ; Arnold Lee Daniel, Alkynyl and azido-substituted 4-anilinoquinazolines.
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Soler Jose Cabo,ESX ; Gisbert Juan Bautista Peris,ESX, Composition and topical formulation of antiandrogens of natural (plant) origin.
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Hocquaux Michel,FRX ; Bakkar Khalid,FRX ; Galey Jean Baptiste,FRX ; Terranova Eric,FRX, Composition for slowing down the loss of hair based on pyrimidine N-oxides triaminosubstituted or their sulfoconjugated.
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Green Martin R. (Water Stratford GB3), Cosmetic composition containing an aryl-substituted ethylene.
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Panaretto Basil A. (Cheltenham AUX) Moore Geoffrey P. M. (North Ryde AUX) Robertson Duncan M. (Mosman AUX), Defleecing compounds.
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Barrows, Thomas H., Filamentary means for introducing agents into tissue of a living host.
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Tankovich Nikolai I. ; Zhao Zhong-Quan ; Fairchild Paul, Hair removal method.
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Bauman, John G; Guilford, William J; Parkinson, John F; Skuballa, Werner; Subramanyam, Babu, Lipoxin A4 analogs.
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McDaniel, David H., Method and apparatus for the stimulation of hair growth.
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Jimenez Joaquin J. (Miami FL) Yunis Adel A. (Miami FL), Method of preventing and treating chemotherapy-induced alopecia.
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McDaniel, David, Process for stimulating hair growth.
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Barker Andrew J. (Macclesfield GB2), Quinazoline derivatives useful for treatment of neoplastic disease.
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Kobayashi Koji,JPX ; Fukunishi Hirotada,JPX ; Magara Tsunao,JPX, Quinazolinone derivative, hair growth promoter and external composition for skin using the same.
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Henry James P. ; Ahluwalia Gurpreet S., Reduction of hair growth.
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McDaniel David H., Reduction, elimination, or stimulation of hair growth.
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Barrows,Thomas H., Scaffolds for tissue engineered hair.
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Sanner, Mark A.; Helal, Chris J.; Cooper, Christopher B., Thiazole derivatives.
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Weber, Paul J.; Da Silva, Luiz B.; Rubenchik, Alexander M., Tissue removal using biocompatible materials.
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Seung Yeob Lee KR; Jin Seok Kang KR; Jeom Soon Shim KR; Seung Wook Lim KR; Seung Hee Han KR; Byoung Kwang Lee KR; Young Hyo Yu KR; Jong Keun Chung KR, Topical composition containing human epidermal growth factor.
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Max Werner Scheiwe DE; Shitotomo Yamauchi JP, Topical formulation of alkyl-, phenyl-pyridone.
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이 특허를 인용한 특허 (4) 인용/피인용 타임라인 분석

Wang, Jingyi; Fan, Chuanwen; Zhang, Long; Guo, Zhongru; Li, Ying; Yang, Shaobo; Yan, Shousheng; Zhu, Jianrong; Yang, Qingmin; Zhang, Minghui, 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors.
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Cotsarelis, George; Ito, Mayumi, Methods for generating new hair follicles, treating baldness, and hair removal.
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Cotsarelis, George; Ito, Mayumi, Methods for generating new hair follicles, treating baldness, and hair removal.
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Ross, Christopher; Roberts, David; Lawson, Anne M., Tin-free catalysts for cross-linked polyethylene pipe and wire.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Methods, kits, and compositions for generating new hair follicles and growing hair 원문보기