Oxygen enhancing membrane systems for implantable devices
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/05
A61B-005/00
출원번호
US-0410555
(2006-04-25)
등록번호
US-8255030
(2012-08-28)
발명자
/ 주소
Petisce, James
Tapsak, Mark A.
Simpson, Peter C.
Carr-Brendel, Victoria
Brauker, James H.
출원인 / 주소
DexCom, Inc.
대리인 / 주소
Knobbe, Martens, Olson & Bear, LLP.
인용정보
피인용 횟수 :
7인용 특허 :
380
초록▼
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic rea
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
대표청구항▼
1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the device comprising: a sensor configured for implantation in a host, the sensor configured to operatively connect with electronic circuitry configured to generate a signal associated with a concentra
1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the device comprising: a sensor configured for implantation in a host, the sensor configured to operatively connect with electronic circuitry configured to generate a signal associated with a concentration of an analyte in a host; anda membrane located over the sensor and configured to control a flux of oxygen and the analyte therethrough, wherein the membrane comprises a material having an oxygen permeability of from about 5 Barrers to about 1000 Barrers. 2. The device of claim 1, wherein the material comprises a copolymer comprising a fluorocarbon segment. 3. The device of claim 2, wherein the fluorocarbon segment is perfluorinated. 4. The device of claim 2, wherein the copolymer further comprises a polycarbonate segment. 5. The device of claim 2, wherein the copolymer has an oxygen solubility of about 50-volume %. 6. The device of claim 2, wherein the membrane comprises a blend, wherein the blend comprises the copolymer and a hydrophilic polymer. 7. The device of claim 6, wherein the hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone, polyhydroxyethyl methacrylate, polyvinylalcohol, polyacrylic acid, polyethers, and copolymers thereof. 8. The device of claim 1, wherein the membrane has a thickness of from about 3 microns to about 65 microns. 9. The device of claim 1, wherein the membrane comprises an enzyme domain, wherein the enzyme domain comprises an enzyme configured to react with the analyte. 10. The device of claim 1, wherein the membrane is configured to limit or block passage of interfering species therethrough. 11. The device of claim 1, wherein the membrane is configured to provide protection to the sensor from a biological environment. 12. The device of claim 1, wherein the material has an oxygen permeability of at least about 10 Barrers. 13. The device of claim 1, wherein the material has an oxygen permeability of at least about 100 Barrers. 14. The device of claim 1, wherein the material has an oxygen permeability of at least about 500 Barrers. 15. The device of claim 1, wherein the material has an oxygen permeability of at least about 800 Barrers. 16. The device of claim 1, wherein the analyte is glucose. 17. The device of claim 1, wherein the membrane has an oxygen permeability from about 30 Barrers to about 1000 Barrers. 18. The device of claim 1, wherein the membrane comprises a domain that has an oxygen permeability from about 30 Barrers to about 1000 Barrers. 19. The device of claim 1, wherein the material has an oxygen solubility that is from about three times to about ten times greater than an oxygen solubility of aqueous media. 20. An implantable device for continuous in vivo measurement of a glucose concentration in a host, the device comprising: a sensor operatively connected to electronic circuitry configured to generate a signal associated with a concentration of glucose in a host; anda membrane located over the sensor and configured to control a flux of oxygen and glucose therethrough, wherein the membrane comprises a material having an oxygen permeability of from about 5 Barrers to about 1000 Barrers, wherein the material comprises a copolymer comprising a fluorocarbon segment and a polycarbonate segment, wherein the membrane has a thickness of from about 3 microns to about 65 microns, and wherein the membrane comprises an enzyme domain comprising an enzyme configured to react with glucose. 21. The device of claim 20, wherein the material has an oxygen solubility that is from about three times to about ten times greater than an oxygen solubility of aqueous media.
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이 특허에 인용된 특허 (380)
Allen Douglas J. (Indianapolis IN) Nevin Robert S. (Albuquerque NM), Acrylic copolymer membranes for biosensors.
Shults, Mark C.; Brauker, James H.; Carr-Brendel, Victoria; Tapsak, Mark A.; Markovic, Dubravka; Updike, Stuart J.; Rhodes, Rathbun K., Analyte measuring device.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S. ; Friedman Keith A. ; Colman Fredric C., Analyte monitoring device and methods of use.
Causey ; III James D. ; Kovelman Paul H. ; Purvis Richard E. ; Mastrototaro John J., Analyte sensor and holter-type monitor system and method of using the same.
Bcker Dirk (Heidelberg DEX) Haar Hans-Peter (Wiesloch DEX) Blasberg Peter (Weinheim DEX) Kotulla Reinhard (Lambsheim DEX), Analytical system for monitoring a substance to be analyzed in patient-blood.
Blackburn Gary ; Creager Stephen E. ; Fraser Scott ; Irvine Bruce D. ; Meade Thomas J. ; O'Connor Stephen D. ; Terbrueggen Robert H. ; Vielmetter Jost G. ; Welch Thomas W., Binding acceleration techniques for the detection of analytes.
Grasel Timothy G. (Madison WI) Cooper Stuart L. (Madison WI), Biocompatible polyurethanes modified with lower alkyl sulfonate and lower alkyl carboxylate.
Eugene P. Goldberg ; Ali Yahiaoui ; Khalid Mentak MA; Theresa Rivero Erickson ; James Seeger, Biofunctional surface modified ocular implants, surgical instruments, medical devices, prostheses, contact lenses and the like.
Shaffer Thomas H. (Lansdowne PA) Wolfson Marla R. (Philadelphia PA) Miller Thomas F. (Philadelphia PA) Foust ; III Raymond (Philadelphia PA), Breathable liquid elimination analysis.
Goldberg Eugene P. (Gainesville FL) Yahiaoui Ali (Gainesville FL) Burns James (Holliston MA), Combined plasma and gamma radiation polymerization method for modifying surfaces.
Gough David A. (Cardiff CA) Lucisano Joseph Y. (La Jolla CA) Armour Jon C. (La Jolla CA) McKean Brian D. (San Diego CA), Complete glucose monitoring system with an implantable, telemetered sensor module.
Sternina Larisa F. (Moscow SUX) Mikhailovich Victor (Moscow SUX) Fedotov Alexander F. (Moscow SUX) Shkolnik Mark I. (Moscow SUX) Strukova Vera V. (Moscow SUX), Composite membrane of a hydrophilic asymmetric membrane coated with an organosiloxane block copolymer.
Gale,David C.; Kleine,Klaus; Abbate,Anthony J.; Atladottir,Svava Maria; Pacetti,Stephen D., Compositions containing fast-leaching plasticizers for improved performance of medical devices.
Lee Chi-Long (Midland MI) Gornowicz Gerald A. (Midland MI) Larkin Frank P. (Roswell GA) Mikami Ryuzo (Ichihara JPX), Container, method and composition for controlling the release of a volatile liquid from an aqueous mixture.
Ward Robert S. (Lafayette CA) White Kathleen A. (Pleasant Hill CA), Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecul.
Olstein Alan (Mendota Heights MN), Cross-linked gas permeable membrane of a cured perfluorinated urethane polymer, and optical gas sensors fabricated there.
Olstein Alan (Mendota Heights MN), Cross-linked gas permeable membrane of a cured perfluorinated urethane polymer, and optical gas sensors fabricated there.
Van Antwerp William Peter ; Mastrototaro John Joseph ; Lane Stephen M. ; Satcher ; Jr. Joe H. ; Darrow Christopher B. ; Peyser Thomas A. ; Harder Jennifer, Detection of biological molecules using boronate-based chemical amplification and optical sensors.
Gross Joseph,ILX ; Reingewirtz Meir,ILX ; Katz Moshe George,ILX, Device and method of calibrating and testing a sensor for in vivo measurement of an analyte.
Berner, Bret; Dunn, Timothy C.; Farinas, Kathleen C.; Garrison, Michael D.; Kurnik, Ronald T.; Lesho, Matthew J.; Potts, Russell O.; Tamada, Janet A.; Tierney, Michael J., Device for signal processing for measurement of physiological analytes.
Roorda Wouter E. ; Dionne Keith E. ; Brown James E. ; Wright Jeremy C. ; Davis Craig R. ; Prestrelski Steven J. ; Tzannis Stelios T., Diffusional implantable delivery system.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S., Electrochemical analyte.
James Say ; Michael F. Tomasco ; Adam Heller ; Yoram Gal IL; Behrad Aria ; Ephraim Heller ; Phillip John Plante ; Mark S. Vreeke, Electrochemical analyte sensor.
Ross Pepi (745 Contra Costa Ave. Berkely ; Alameda CA) Madou Marc J. (3680 Bryant St. Palo Alto ; Santa Clara CA) Reyes Zoila (317 Yale Rd. Menlo Park ; San Mateo CA) Jensen Joel F. (641 Towle Way Pa, Electrochemical cncentration detector method.
Ross Pepi (Berkely CA) Madou Marc J. (Palo Alto CA) Reyes Zoila (Menlo Park CA) Jensen Joel F. (Palo Alto CA) Wing Sharon W. (Cupertino CA) Rimer Virginia G. (Mountain View CA), Electrochemical concentration detector device.
Maley Thomas C. (Medway MA) D\Orazio Paul A. (Mendon MA) Dalzell Bonnie C. (Sherborn MA) Edelman Peter G. (Franklin MA) Flaherty James E. (Attleboro MA) Mason Richard W. (Millis MA) McCaffrey Robert , Electrochemical sensors.
D\Orazio Paul A. (Mishawaka IN) Eddy ; Jr. Arthur R. (Depew NY) Fogt Eric J. (Maple Grove MN) Jones James E. (Elkhart IN) Oberhardt Bruce J. (Mishawaka IN), Enzyme electrode membrane.
Gregg Brian A. (13940 Braun Dr. Golden CO 80401) Heller Adam (5317 Valburn Cir. Austin TX 78731) Kerner Wolfgang (Universitat Zu Lubeck ; Klinik Fur Innerere Medizin ; Razeburger Allee 160 D-2400 Lub, Enzyme electrodes.
Lord Peter C. (Santa Clarita CA) Van Antwerp William P. (Brentwood CA) Mastrototaro John J. (Los Angeles CA) Cheney ; II Paul S. (Beverly Hills CA) Schnabel Nannette M. (Valencia CA), Flex circuit connector.
Mueller Karl F. (New York NY) Plankl Walter L. (Yorktown Heights NY), Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymer hydrogels and contact lenses thereof.
Mueller Karl F. (New York NY) Plankl Walter L. (Yorktown Heights NY), Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymers and contact lenses thereof.
Ford, Russell; Lesho, Matthew J.; Potts, Russell O.; Tierney, Michael J.; Wei, Charles W., Formulation and manipulation of databases of analyte and associated values.
Avrillon Ren (Maison Laffite FRX) Deschamps Andr (Noisy le Roi FRX) Driancourt Alain (Bourg la Reine FRX) Mileo Jean-Claude (Saint Ismier FRX) Robert Eric (Rueil Malmaison FRX), Gas separation membrane.
Schulman Joseph H. (Santa Clarita CA) Rule ; III Orville R. (Los Angeles CA) Whitmoyer David I. (Los Angeles CA) Lebel Ronald J. (Sherman Oaks CA) Lucisano Joseph Y. (Saugus CA) Mann Alfred E. (Bever, Glucose monitoring system.
Lai, Yu-Chin; Baccei, Louis J., Hydrogel from polysiloxane-containing urethane prepolymer, tris (trimethylsiloxy) silylpropyl methacrylate, and a hydrophilic comonomer.
Lai, Yu-Chin; Baccei, Louis J., Hydrogel from polysiloxane-containing urethane prepolymer, tris (trimethylsiloxy) silylpropyl methacrylate, and a hydrophilic comonomer.
Keogh Philip L. (Pittsford NY) Kunzler Jay F. (Canadaigua NY) Niu Gregory C. C. (Lexington MA), Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hy.
Allen Douglas J. (Indianapolis IN) Johnson Kirk W. (Indianapolis IN) Nevin Robert S. (Indianapolis IN), Hydrophilic polyurethane membranes for electrochemical glucose sensors.
Bennetto Hugh P. (London GB3) Delaney Gerard M. (London GB3) Mason Jeremy R. (London GB3) Thurston Christopher F. (London GB3) Stirling John L. (London GB3) DeKeyzer David R. (Old Woking GB3), Immobilized enzyme electrodes.
Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Scharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasconcellos Alfred V. ; Lysaght M, Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products.
Butler Mark D. ; Davidson Daniel F. ; Mish Stanley L. ; Moore ; III James W., Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein.
Lin Leu-Fen H. ; Collins Franklin D. ; Doherty Daniel H. ; Lile Jack ; Bektesh Susan, Implantable device containing GDNF secreting cells for treating nerve damage and methods of use.
Schulman, Joseph H.; Byers, Charles L.; Adomian, Gerald E.; Colvin, Michael S., Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces.
Joseph H. Schulman ; Charles L. Byers ; Gerald E. Adomian ; Michael S. Colvin, Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces.
Schulman Joseph H. ; Byers Charles L. ; Adomian Gerald E. ; Colvin Michael S., Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces.
Bessman Samuel P. (2025 Zonal Ave. Los Angeles CA 90033) Layne Ennis C. (9128 Huntington Dr. San Gabriel CA 91775) Thomas Lyell J. (1900 Pelican Ave. San Pedro CA 90732), Implantable glucose sensor.
Wilson George S. (Lawrence KS) Bindra Dilbir S. (Lawrence KS) Hill Brian S. (Lawrence KS) Thevenot Daniel R. (Paris Cedex FRX) Sternberg Robert (Thiais FRX) Reach Gerard (Paris Cedex KS FRX) Zhang Ya, Implantable glucose sensor.
Erickson Brian J. (Woodbury MN) Hilgers Michael E. (Roseville MN) Hendrickson Tracy A. (Minnetonka MN) Shapland J. Edward (Shoreview MN) Solomon Frank A. (Plymouth MN) Knudson Mark B. (Shoreview MN), Interstitial fluid collection and constituent measurement.
Erickson Brian J. ; Hilgers Michael E. ; Hendrickson Tracy A. ; Shapland J. Edward ; Solomon Frank A. ; Knudson Mark B., Interstitial fluid collection and constituent measurement.
Say, James L.; Sakslund, Henning; Tomasco, Michael F.; Audett, Jay D.; Cho, Hyun; Yamasaki, Duane O.; Heller, Adam, Mass transport limited in vivo analyte sensor.
Pfeiffer Ernst (Stauffenbergstr. 34 89075 Ulm DEX) Sternberg Fabio (Robert-Stolz-Str. 17 89231 Neu-Ulm DEX), Method and apparatus for continuously monitoring the concentration of a metabolyte.
Pizziconi Vincent B. (3535 E. Highline Canal Rd. Phoenix AZ 85040) Towe Bruce C. (2331 S. Paseo Loma Cir. Mesa AZ 85202), Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids.
Luong John H. T. (Mount Royal CAX) Male Keith B. (Pierrfonds CAX) Cattaneo Maurice V. (Outremont CAX), Method and system for determining bioactive substances.
Mier Randall M. (215 Nepean Avenue #1107 Ottawa ; Ontario NJ CAX K2P 0B7) Piznik Sylvia (12 Corrinne Ct. Jackson NJ 08527) Lauks Imants R. (1011 Yardley-Morrisville Rd. Yardley PA 19067) Davis Graham, Method of forming a permselective layer.
Duan Daniel C. (St. Paul MN) Schaberg Mark S. (Maplewood MN) Fogarty Terence M. (Hudson WI) Howard ; Jr. William L. (Manhattan Beach CA) Wood Kenneth B. (St. Paul MN), Method of making blood gas sensors overcoats using permeable polymeric compositions.
Tietje-Girault Jordis (1088 Ropraz En Vernay CHX) Seddon Brian J. (Chemin De Fonadel 37 Prilly ; Lausanne ; CH1008 CHX) McAleer Jerome F. (52 Nobles ; Grove Wantage ; Oxfordshire OX12 ONR GBX), Method of making gas permeable membranes for amperometric gas electrodes.
Cozzette Stephen N. (Hightstown NJ) Davis Graham (Plainsboro NJ) Itak Jeanne (Hamilton NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Ottawa NJ CAX) Piznik Sylvia (Jackson NJ) Smit Nicolaas (Hight, Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor.
Cozzette Stephen N.,CAX ; Davis Graham ; Lauks Imants R. ; Mier Randall M. ; Piznik Sylvia ; Smit Nicolaas ; Van der Werf Paul ; Wieck Henry J., Methods for microdispensing patterened layers.
Wohlstadter Jacob N. ; Wilbur James ; Sigal George ; Martin Mark ; Guo Liang-Hong ; Fischer Alan ; LeLand Jon, Multi-array, multi-specific electrochemiluminescence testing.
Winters Suzanne (Salt Lake City UT) Solen Kenneth A. (Orem UT) Sanders Clifton G. (Salt Lake City UT) Mortensen J. D. (Sandy UT) Berry Gaylord (Salt Lake City UT), Multifunctional thrombo-resistant coating and methods of manufacture.
Domb Abraham J.,ILX ; Gref Ruxandra,FRX ; Minamitake Yoshiharu,JPX ; Peracchia Maria Teresa,ITX ; Langer Robert S., Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers.
Clark ; Jr. Leland (Cincinnati OH), Polarographic method for measuring both analyte and oxygen with the same detecting electrode of an electroenzymatic sens.
Gulati,Poonam S.; Chattaraj,Sarnath; Minnoor,Elango S.; Levin,Eugene; Zhu,Xiao; Van Antwerp,William P., Polypeptide formulations and methods for making, using and characterizing them.
Hammar W. James (St. Paul MN) Staral John S. (St. Paul MN), Polyurethanes and polyurethane/polyureas crosslinked using 2-glyceryl acrylate or 2-glyceryl methacrylate.
Cozzette Stephen N. (Nepean CAX) Davis Graham (Plainsboro NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Morrisvile PA) Piznik Sylvia (Jackson NJ) Smit Nicolaas (Hightstown NJ) Van Der Werf Paul (, Process for the manufacture of wholly microfabricated biosensors.
Cozzette Stephen N. (Nepean NJ CAX) Davis Graham (Plainsboro NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Morrisvile PA) Piznik Sylvia (Jackson NJ) Smit Nicolaas (Hightstown NJ) Van Der Werf Pau, Process for the manufacture of wholly microfabricated biosensors.
Cozzette Stephen N.,CAX ; Davis Graham ; Lauks Imants R. ; Mier ; deceased Randall M. ; Piznik Sylvia ; Smit Nicolaas ; Van Der Werf Paul ; Wieck Henry J. ; Steiner Susan ; Itak Jeanne, Process for the manufacture of wholly microfabricated biosensors.
Kaufmann Rudolf (Burghausen DEX) Mller Johann (Burghausen DEX) Wegehaupt Karl-Heinrich (Burghausen DEX), Process for the preparation of organopolysiloxanes.
Richard D Antanavich ; Randel Dorian, RETRIEVABLE BIOARTIFICIAL IMPLANTS HAVING DIMENSIONS ALLOWING RAPID DIFFUSION OF OXYGEN AND RAPID BIOLOGICAL RESPONSE TO PHYSIOLOGICAL CHANGE, PROCESSES FOR THEIR MANUFACTURE, AND METHODS FOR THEIR U.
Shin, John J.; Holtzclaw, Kris R.; Dangui, Nandita D.; Kanderian, Jr., Sami; Mastrototaro, John J.; Hong, Peter I., Real time self-adjusting calibration algorithm.
Babcock Walter C. (Bend OR) Friesen Dwayne T. (Bend OR), Semipermeable thin-film membranes comprising siloxane, alkoxysilyl and aryloxysilyl oligomers and copolymers.
Karinka, Shridhara Alva; Moser, Isabella; Jobst, Gerhard; Tietjen, Uwe; Petrou, Panagiota S.; Herberth, Uwe; Urban, Gerald, Sensor having electrode for determining the rate of flow of a fluid.
Berner Bret ; Dunn Timothy C. ; Farinas Kathleen C. ; Garrison Michael D. ; Kurnik Ronald T. ; Lesho Matthew J. ; Potts Russell O. ; Tamada Janet A. ; Tierney Michael J., Signal processing for measurement of physiological analysis.
Benjamin J. Feldman ; Adam Heller ; Ephraim Heller ; Fei Mao ; Joseph A. Vivolo ; Jeffery V. Funderburk ; Fredric C. Colman ; Rajesh Krishnan, Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator.
Goldberg Eugene P. (Gainesville FL) Burns James W. (Holliston MA) Kumar G. Sudesh (Maharastra MO INX) Osborn David C. (Manchester MO) Larson Jeffrey A. (Santa Barbara CA) Sheets John W. (Pasadena CA), Surface modified surgical instruments, devices, implants, contact lenses and the like.
Goldberg Eugene P. (Gainesville FL) Burns James W. (Natick MA) Kumar G. Sudesh (Maharastra MO INX) Osborn David C. (St. Louis MO) Larson Jeffrey A. (Monrovia CA) Sheets John W. (Clearmont CA) Yahiaou, Surface modified surgical instruments, devices, implants, contact lenses and the like.
Goldberg Eugene P. (Gainesville FL) Vahiaoui Ali (Gainesville FL), Surface modified surgical instruments, devices, implants, contact lenses and the like.
Yacynych Alexander M. (East Brunswick NJ) Piznik Sylvia S. (Jackson NJ) Reynolds Eugene R. (Highland Park NJ) Geise Robert J. (Piscataway NJ), Surface-modified electochemical biosensor.
Audrey A. Sherman ; Kurt C. Melancon ; Walter R. Romanko ; Mieczyslaw H. Mazurek ; Albert I. Everaerts, Tackified polydiorganosiloxane oligourea segmented copolymers and a process for making same.
Grill ; Jr. Warren M. (Cleveland Hts. OH) Creasey Graham H. (Cleveland Hts. OH) Ksienski David A. (Hermosa Beach CA) Veraart Claude S. (Brussels OH BEX) Mortimer J. Thomas (Chagrin Falls OH), Thin film implantable electrode and method of manufacture.
Brenner Otto (Edingen DEX) Ermert Wolfgang (Weinheim DEX) Eschwey Helmut (Gorxheimertal DEX) Esswein Gerd (Maxdorf DEX) Schuhmacher Gnter (Weinheim DEX), Tissue-compatible medical device and method for manufacturing the same.
Cheney ; II Paul S. (Beverly Hills CA) Mastrototaro John J. (Los Angeles CA) Schnabel Nannette M. (Valencia CA) Lord Peter C. (Valencia CA) Van Antwerp William P. (Los Angeles CA) Clark Raymond D. (V, Transcutaneous sensor insertion set.
Lord Peter C. (Santa Clarita CA) Van Antwerp William P. (Brentwood CA) Mastrototaro John J. (Los Angeles CA) Cheney ; II Paul S. (Beverly Hills CA) Schnabel Nannette M. (Valencia CA), Transcutaneous sensor insertion set.
Ueda Fumio (Iwakuni JPX) Hashimoto Eiichi (Iwakuni JPX) Yamada Takeyoshi (Iwakuni JPX) Mori Koh (Iwakuni JPX), Ultrathin film, process for production thereof, and use thereof for concentrating a specified gas in a gaseous mixture.
Robertson J. Richard (Alpharetta GA) Su Kai C. (Alpharetta GA) Goldenberg Merrill S. (Teaneck NJ) Mueller Karl F. (New York NY), Wettable, flexible, oxygen permeable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units.
Cozzette Stephen N. (Nepean CAX) Davis Graham (Plainsboro NJ) Itak Jeanne A. (North Brunswick NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Morrisville PA) Piznik Sylvia (Jackson NJ) Smit Nicolaa, Wholly microfabricated biosensors and process for the manufacture and use thereof.
Petisce, James R.; Tapsak, Mark A.; Simpson, Peter C.; Carr-Brendel, Victoria E.; Brauker, James H., Oxygen enhancing membrane systems for implantable devices.
Petisce, James R.; Tapsak, Mark A.; Simpson, Peter C.; Carr-Brendel, Victoria; Brauker, James H., Oxygen enhancing membrane systems for implantable devices.
Petisce, James R.; Tapsak, Mark A.; Simpson, Peter C.; Carr-Brendel, Victoria; Brauker, James H., Oxygen enhancing membrane systems for implantable devices.
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