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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0569367 (2009-09-29) |
등록번호 | US-8268144 (2012-09-18) |
발명자 / 주소 |
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출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 453 |
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agen
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
1. A sensor for determining a concentration of an analyte in a sample, the sensor comprising: a first substrate and a second substrate disposed over the first substrate, wherein the first and second substrates define a sensor comprising a proximal end and a distal end, the distal end being configure
1. A sensor for determining a concentration of an analyte in a sample, the sensor comprising: a first substrate and a second substrate disposed over the first substrate, wherein the first and second substrates define a sensor comprising a proximal end and a distal end, the distal end being configured and arranged for insertion into a sensor reader, a first side edge and a second side edge extending from the proximal end to the distal end of the sensor, and the proximal end of the sensor comprising first and second extensions;a spacer disposed between the first and second substrates and defining a first aperture along the first side edge of the sensor, a second aperture along the second side edge of the sensor, and a sample chamber extending with a substantially uniform width from the first aperture to the second aperture;a working electrode disposed on the first substrate;an analyte-responsive enzyme disposed on the working electrode;a counter electrode disposed on the second substrate, wherein the working electrode and the counter electrode are positioned relative to the sample chamber to generate an analyte-responsive signal when sample containing analyte is disposed in the sample chamber;an indicator electrode disposed on at least one of the first and second substrates and positioned relative to a sample flow path within the sample chamber to indicate that, when sample contacts the indicator electrode, the sample chamber is filled with sample. 2. The sensor of claim 1, wherein the analyte is glucose or a ketone. 3. The sensor of claim 1, wherein portions of the first and second side edges proximate to the first and second apertures are straight. 4. The sensor of claim 1, wherein the sample chamber comprises two opposing straight edges extending between the first and second openings of the first and second side edges. 5. The sensor of claim 1, wherein the indicator electrode is configured and arranged to aid in electrolysis of the analyte. 6. The sensor of claim 5, wherein the counter electrode extends over substantially all of the sample chamber. 7. The sensor of claim 1, wherein the sensor comprises a second indicator electrode, wherein the first indicator electrode is positioned relative to the sample chamber to determine when the sample chamber begins to fill with sample and the second indicator electrode is positioned relative to the sample chamber to determine when the sample chamber is filled with sample. 8. The sensor of claim 7, wherein the working electrode and the counter electrode are positioned between the first and second indicator electrodes. 9. The sensor of claim 1, wherein the sample chamber comprises two opposing edges between the first and second side edges, the edges defining an expanded region in the sample chamber. 10. The sensor of claim 1, further comprising a diffusible redox mediator disposed in the sample chamber. 11. The sensor of claim 10, wherein the diffusible redox mediator is disposed on the working electrode. 12. The sensor of claim 1, further comprising a second electron transfer agent disposed in the sample chamber. 13. The sensor of claim 12, wherein the second electron transfer agent is disposed on the working electrode. 14. The sensor of claim 12, wherein the second electron transfer agent is diffusible. 15. The sensor of claim 1, wherein the working electrode extends over substantially all of the sample chamber. 16. The sensor of claim 1, wherein the sample chamber is sized to contain a volume of no more 1 μl of sample. 17. The sensor of claim 1, wherein the sample chamber is sized to contain a volume of no more than 0.5 μL, of sample. 18. The sensor of claim 1, wherein at least a portion of the working electrode is no more than 200 μm from a portion of the counter electrode. 19. The sensor of claim 1, wherein the indicator electrode is configured and arranged for use as a counter electrode. 20. The sensor of claim 1, wherein the indicator electrode is configured and arranged for use as a working electrode. 21. The sensor of claim 1, wherein the indicator electrode is disposed on at least one of the first and second substrates and positioned, relative to a sample flow path within the sample chambers after the working and counter electrodes to indicate when the sample chamber is sufficiently filled with sample. 22. A sensor for determining a concentration of analyte in a sample, the sensor comprising: a first substrate and a second substrate disposed over the first substrate, wherein the first and second substrates define a sensor comprising a proximal end and a distal end, the distal end being configured and arranged for insertion into a sensor reader, a first side edge and a second side edge extending from the proximal end to the distal end of the sensor, and the proximal end of the sensor comprising first and second extensions;a spacer disposed between the first and second substrates and defining a first aperture along the first side edge of the sensor, a second aperture along the second side edge of the sensor, and a sample chamber extending with a substantially uniform width from the first aperture to the second aperture;a working electrode disposed on the first substrate;an analyte-responsive enzyme disposed on the working electrode;a counter electrode disposed on the second substrate, wherein the working electrode and the counter electrode are positioned relative to the sample chamber to generate an analyte-responsive signal when sample containing analyte is disposed in the sample chamber; andan indicator electrode disposed on at least one of the first and second substrates and positioned relative to the sample chamber to determine when the sample chamber contains sample. 23. A sensor for determining a concentration of analyte in a sample, the sensor comprising: a first substrate and a second substrate disposed over the first substrate, wherein the first and second substrates define a sensor comprising a proximal end and a distal end, the distal end being configured and arranged for insertion into a sensor reader, a first side edge and a second side edge extending from the proximal end to the distal end of the sensor, and the proximal end of the sensor comprising first and second extensions;a spacer disposed between the first and second substrates and defining a first aperture along the first side edge of the sensor, a second aperture along the second side edge of the sensor, and a sample chamber extending with a substantially uniform width from the first aperture to the second aperture;a working electrode disposed on the first substrate;an analyte-responsive enzyme disposed on the working electrode;a counter electrode disposed on the second substrate, wherein the working electrode and the counter electrode are positioned relative to the sample chamber to generate an analyte-responsive signal when sample containing analyte is disposed in the sample chamber; andan indicator electrode disposed on at least one of the first and second substrates, wherein the indicator electrode is configured and arranged to aid in electrolysis of the analyte. 24. A sensor for determining a concentration of analyte in a sample, the sensor comprising: a first substrate and a second substrate disposed over the first substrate, wherein the first and second substrates define a sensor comprising a proximal end and a distal end, the distal end being configured and arranged for insertion into a sensor reader, a first side edge and a second side edge extending from the proximal end to the distal end of the sensor, and the proximal end of the sensor comprising first and second extensions;a spacer disposed between the first and second substrates and defining a first aperture along the first side edge of the sensor, a second aperture along the second side edge of the sensor, and a sample chamber extending with a substantially uniform width from the first aperture to the second aperture;a working electrode disposed on the first substrate;an analyte-responsive enzyme disposed on the working electrode;a counter electrode disposed on the second substrate, wherein the working electrode and the counter electrode are positioned relative to the sample chamber to generate an analyte-responsive signal when sample containing analyte is disposed in the sample chamber; andan indicator electrode disposed on at least one of the first and second substrates, wherein the indicator electrode comprises first and second indicator electrodes, the first indicator electrode is positioned relative to the sample chamber to determine when the sample chamber begins to fill with sample and the second indicator electrode is positioned relative to the sample chamber to determine when the sample chamber is filled with sample.
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