[특허]Methods for testing milk

[미국특허] Methods for testing milk 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12Q-001/68 C07H-021/00 A01K-043/00 G01N-033/02 A23C-009/154 A61K-035/16 A61K-038/17
출원번호	US-0079932 (2011-04-05)
등록번호	US-8278046 (2012-10-02)
발명자 / 주소	Medo, Elena M. Lee, Martin L. Rechtman, David J.
출원인 / 주소	Prolacta Bioscience
대리인 / 주소	Cooley LLP
인용정보	피인용 횟수 : 5 인용 특허 : 34

초록

The disclosure is related generally to methods for testing mammary fluid (including milk) to establish or confirm the identity of the donor of the mammary fluid. Such methods are useful in the milk-bank business to improve safety.

대표청구항 ▼

1. A method for processing a donated human breast milk obtained from a specific subject comprising: (a) testing a donated biological sample from the specific subject to obtain at least one reference identity marker profile for at least one marker;(b) testing a sample of the donated human breast milk to obtain at least one identity marker profile for the at least one marker in step (a);(c) comparing the identity marker profiles of steps (a) and (b), wherein a match between the identity marker profiles indicates that the donated human breast milk was obtained from the specific subject;(d) processing the donated human breast milk whose identity marker profile has been matched with a reference identity marker profile, wherein the processing comprises: (i) filtering the donated human breast milk;(ii) heat treating the donated human breast milk;(iii) separating the donated human breast milk into cream and skim;(iv) adding a portion of the cream to the skim to form a human milk composition; and(v) pasteurizing the human milk composition to produce a processed human breast milk composition. 2. A processed human milk composition suitable for administration to an infant made by the process of claim 1. 3. The method of claim 1 wherein the processed human breast milk composition comprises: (a) a human protein constituent of 35-85 mg/mL(b) a human fat constituent of 60-110 mg/mL(c) a human carbohydrate constituent of 60-140 mg/mL. 4. The method of claim 1, wherein the method further comprises adding to the processed human breast milk one or more constituents selected from the group consisting of: calcium, chloride, copper, iron, magnesium, manganese, phosphorus, potassium, sodium, and zinc. 5. The method of claim 1, wherein the testing of the donated human breast milk of step (b) and the testing of the donated biological sample of step (a) comprises nucleic acid typing. 6. The method of claim 5, wherein the nucleic acid typing comprises a method selected from the group consisting of: STR analysis, HLA analysis, multiple gene analysis, and a combination thereof. 7. The method of claim 1, wherein the donated human breast milk sample of step (b) comprises a mixture of one or more breast milk samples from the specific subject. 8. The method of claim 1, wherein the testing of the donated human breast milk sample of step (b) and the testing of the donated biological sample of step (a) comprises antibody testing to obtain a self-antigen profile. 9. The method of claim 1, wherein the identity marker profiles obtained in steps (a) and (b) comprise peptide markers. 10. The method of claim 1, wherein the donated biological sample is selected from a group consisting of: milk, saliva, buccal cell, hair root, and blood. 11. The method of claim 1, wherein lack of a match between the identity marker profiles obtained in steps (a) and (b) indicates contamination of the donated human breast milk sample. 12. The method of claim 1, wherein steps (a) through (c) are carried out at a human breast milk donation center or at a milk processing facility. 13. The method of claim 1, wherein steps (a) and (b) are carried out at different facilities. 14. The method of claim 13, wherein step (a) is carried out at a human breast milk donation facility and step (b) is carried out at a milk processing facility. 15. The method of claim 3 wherein the method further comprises adding the processed human breast milk composition to human breast milk to obtain a fortified human breast milk sample.

이 특허에 인용된 특허 (34) 인용/피인용 타임라인 분석

Herman, Ira; Welch, Alice Y., β-cap73 control of normal and abnormal cell migration.
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Ceriani Robeto L. ; Peterson Jerry A. ; Larocca David J., 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein.
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Schuster David M. (Poolesville MD) Berninger Mark S. (Gaithersburg MD), Amplification of nucleic acid molecules.
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Peterson Jerry A. (Lafayette CA) Yolken Robert H. (Baltimore MD) Newburg David S. (Newtonville MA), Anti-diarrheic product and method of treating rotavirus-associated infection.
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Hochstedler Judy R. ; Hochstedler Curtis G., Breast pump.
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McMahon, Robert J.; Locniskar, Mary Frances; Rumsey, Steven Charles; Anthony, Joshua C.; Wungtanagorn, Ratchapong, Compositions and methods of formulation for enteral formulas containing sialic acid.
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Sagara Kazuhiko (Yamanashi JPX) Ueda Kunio (Yamanashi JPX) Shimada Toshikazu (Yamanashi JPX) Ishii Toshiaki (Tokorozawa JPX), Continuous production process of cheese curds and production process of cheese therefrom.
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Seiberling Dale A. (Roscoe IL), Continuous separating and standardizing of milk.
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McMahon, Robert J.; Locniskar, Mary Frances; Rumsey, Steven Charles; Anthony, Joshua C.; Wantanagorn, Ratchapong, Enteral compositions containing caseinoglycomacropeptide having an enhanced concentration of sialic acid.
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Bjursell Karl G. (Partille SEX) Carlsson Peter N. I. (Goteborg SEX) Enerback Curt S. M. (Molndal SEX) Hansson Stig L. (Ume SEX) Lidberg Ulf F. P. (Goteborg SEX) Nilsson Jeanette A. (Goteborg SEX) Tor, Genomic DNA sequences encoding human BSSL/CEL.
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Wong Ernest,CAX ; Fauconnier Theresa,CAX ; Nguyen Tam,CAX ; Pollak Alfred,CAX ; Rakhit Suman,CAX, Glycopeptide-chelator conjugates.
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Chow, Robert; Tonai, Richard, High throughput methods of HLA typing.
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Tabb David L. (Elkhart IN) Tyhach Richard J. (Elkhart IN), Homogeneous specific binding assay test device having copolymer enhancing substance.
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Wells, John Cowper Kingston; Hageman, Robert Johan Joseph; Boehm, Gunther; Georgi, Gilda; Sawatzki, Gunther; Bindels, Jacob Geert, Infant formula.
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Gaull Gerald E. ; Gaull by Florence McSherry, Infant formula compositions and method of making.
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Gaull Gerald E., Infant formula compositions and nutrition containing genetically engineered human milk proteins.
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Mowery Kevin M. ; Bartley John P. ; Hantak Robert J. ; Etling Richard E. ; Read Joseph R., Integrated system monitoring use of materials, controlling and monitoring delivery of materials and providing automated.
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Foley, Richard M.; Britto, James J.; Shafer, Ryan, Method and apparatus for storing milk.
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Lindquist, Anders, Method and plant for producing a sterile milk product.
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Sanford Michael D. (Arlington TX), Method and system for inventoring a distributed plurality of items on a supply.
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Erlich Henry A. (Oakland CA) Horn Glenn T. (Framingham MA) Bugawan Teodorica (San Leandro CA) Begovich Ann B. (El Cerrito CA), Method for HLA DP typing.
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Morcol Tulin ; Bell Steve J. D., Method for processing milk.
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Holm ; deceased Sune (late of Lund SEX Ingrid Birgitta Elisabet ; ne Jansson ; Eva Christina Holm ; Claes Frederick Holm ; executors) Malmberg Rolf (Lund SEX) Svensson Kjell (S. Sandby SEX), Method for producing milk with a lowered bacterial content.
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Medo, Elena Maria, Method of producing nutritional products from human milk tissue and compositions thereof.
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Medo, Elena M.; Lee, Martin L.; Rechtman, David J., Methods for testing milk.
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Grant Elena M. (Beaverton OR) Grant ; Jr. David N. (Beaverton OR), Portable electric breast pump.
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Barrett-Reis Bridget ; Reynolds Patricia A. ; Montalto Michael B. ; O'Connor Deborah L., Powdered human milk fortifier.
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Binder Wilhelm (Tiefenbach DEX) Raudszus Gerhard (Zachenberg DEX), Process and apparatus for taking a representative milk sample.
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Moller Wolfgang (Oberusel DEX) Stephan Wolfgang (Stadtprozelten DEX) Hies Henry (Rodermark DEX), Process for the sterile filtration of milk.
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Ettinger Anna C. (11557 Hartland Rd. Fenton MI 48430), Reduction of gastrointestinal disease-producing organisms with sialic acid and gangliosides.
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Kamarel A. Reza, Refrigeration-shelf-stable ultra-pasteurized or pasteurized infant formula.
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Schnhuber Max-J. (Seefeldquai 1 CH 8008 Zrich CHX), System for recording data relating to specific lots of materials, particularly to milk lots.
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Ammann Arthur J. (San Rafael CA), Treatment of HIV-associated immune thrombocytopenic purpura.
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Beck Lee R. ; Ishida Atsunori,JPX ; Yoshikai Yasunobu,JPX ; Murosaki Shinji,JPX ; Kubo Chiharu,JPX ; Hidaka Yoshio,JPX ; Nomoto Kikuo,JPX, Use of hyperimmune milk to prevent suppression of T-lymphocyte production.
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이 특허를 인용한 특허 (5) 인용/피인용 타임라인 분석

Medo, Elena M.; Eaker, Scott, Compositions of human lipids and methods of making and using same.
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Medo, Elena M.; Eaker, Scott, Compositions of human lipids and methods of making and using same.
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Medo, Elena M.; Lee, Martin L.; Rechtman, David J.; Fournell, Joseph, Human milk compositions and methods of making and using same.
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Fournell, Joseph; Eaker, Scott; Elster, Scott; Rechtman, David J., Human milk permeate compositions and methods of making and using same.
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Medo, Elena M.; Lee, Martin L.; Rechtman, David J., Methods for testing milk.
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[미국특허] Methods for testing milk 원문보기