[특허]Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins

[미국특허] Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-005/00
출원번호	US-0016728 (2011-01-28)
등록번호	US-8278098 (2012-10-02)
발명자 / 주소	Alitalo, Kari Jeltsch, Markku M.
출원인 / 주소	Vegenics Pty Limited
대리인 / 주소	Marshall, Gerstein & Borun LLP
인용정보	피인용 횟수 : 2 인용 특허 : 75

초록 ▼

The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.

대표청구항 ▼

1. A method of modulating the growth of mammalian endothelial cells or mammalian endothelial precursor cells, comprising contacting the cells with a polypeptide comprising an amino acid sequence that is at least 95% identical to a chimeric vascular endothelial growth factor (VEGF) amino acid sequence selected from the group consisting of SEQ ID NO: 241 (construct 11-3) or SEQ ID NO: 209 (construct 13-1), wherein the polypeptide binds to human VEGFR-1 and human VEGFR-2, andwherein the polypeptide further includes one or more amino acid sequences selected from the group consisting of a prepro-VEGF-C signal peptide, a prepro-VEGF-C amino-terminal propeptide, and a prepro-VEGF-C carboxy-terminal pro-peptide. 2. The method according to claim 1, wherein the contacting comprises administering a composition comprising said polypeptide and a pharmaceutically acceptable carrier to a mammalian subject. 3. The method according to claim 2, wherein the mammalian subject is a human. 4. The method according to claim 1, wherein the polypeptide comprises a prepro-VEGF-C carboxy terminal propeptide. 5. The method according to claim 1, wherein the polypeptide is purified. 6. A method of modulating the growth of mammalian hematopoietic progenitor cells, comprising the step of contacting the cells with a polypeptide in an amount effective to modulate the growth of the cells, wherein the polypeptide comprising an amino acid sequence of the formula: XN-V/PHD-XC,wherein XN comprises amino acids 1-111 of SEQ ID NO: 22 or a fragment thereof;wherein V/PHD comprises an amino acid sequence at least 95% identical to the amino acid sequence of SEQ ID NO: 241 (construct 11-3) or SEQ ID NO: 209 (construct 13-1);wherein XC comprises amino acids 217-419 of SEQ ID NO: 22 or a fragment thereof;wherein XN and XC are each identical to an amino acid sequence in a naturally occurring human VEGF-C precursor protein; andwherein the polypeptide binds human VEGFR-1 and human VEGFR-2. 7. The method according to claim 6, wherein the contacting comprises administering a composition comprising said polypeptide and a pharmaceutically acceptable carrier to a mammalian subject. 8. The method according to claim 7, wherein the mammalian subject is a human. 9. The method according to claim 6, wherein the polypeptide is purified. 10. A method of modulating the growth of mammalian endothelial cells or mammalian endothelial precursor cells, comprising contacting the cells with a polypeptide comprising an amino acid sequence of the formula: XN-V/PHD-XC,wherein XN comprises amino acids 1-111 of SEQ ID NO: 22 or a fragment thereof;wherein V/PHD comprises an amino acid sequence at least 95% identical to an amino acid sequence of the formula: NH2-X1-X2-X3-X4-X5-X6-X7-X8-X9-COOHwherein X1 is amino acids 3-11 of SEQ ID NO: 128; wherein X2 is SEQ ID NO: 129; wherein X3 is SEQ ID NO: 130; wherein X4 is SEQ ID NO: 131; wherein X5 is SEQ ID NO: 132; wherein X6 is SEQ ID NO: 142; wherein X7 is SEQ ID NO: 134; wherein X8 is SEQ ID NO: 135; and wherein X9 is SEQ ID NO: 136; orwherein X1 is amino acids 3-11 of SEQ ID NO: 128; wherein X2 is SEQ ID NO: 129; wherein X3 is SEQ ID NO: 130; wherein X4 is SEQ ID NO: 131; wherein X5 is SEQ ID NO: 141; wherein X6 is SEQ ID NO: 133; wherein X7 is SEQ ID NO: 134; wherein X8 is SEQ ID NO: 135; and wherein X9 is SEQ ID NO: 136;wherein XC comprises amino acids 217-419 of SEQ ID NO: 22 or a fragment thereof;wherein XN and XC are each identical to an amino acid sequence in a naturally occurring human VEGF-C precursor protein; andwherein the polypeptide binds to human VEGFR-1 and human VEGFR-2. 11. The method according to claim 10, wherein the contacting comprises administering a composition comprising said polypeptide and a pharmaceutically acceptable carrier to a mammalian subject. 12. The method according to claim 11, wherein the mammalian subject is a human.

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[미국특허] Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins 원문보기

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