Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostasis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/36
A61K-038/39
A61K-047/48
A61P-007/02
C07K-014/745
출원번호
US-0082109
(2011-04-07)
등록번호
US-8283320
(2012-10-09)
발명자
/ 주소
Wolff, Jørgen
출원인 / 주소
Ferrosan Medical Devices A/S
대리인 / 주소
Ball, Jonathan D.
인용정보
피인용 횟수 :
0인용 특허 :
101
초록▼
A haemostatic kit to be used as a medical device provides for a containment unit and a haemostatic agent in said containment unit, said haemostatic agent occupying less than 90% of the volume of the containment unit. This allows for facile and consequently sterile preparation of, for instance, a gel
A haemostatic kit to be used as a medical device provides for a containment unit and a haemostatic agent in said containment unit, said haemostatic agent occupying less than 90% of the volume of the containment unit. This allows for facile and consequently sterile preparation of, for instance, a gelatin paste for use in haemostatis when combined with saline, thrombin or another agent to assist in haemostatis.
대표청구항▼
1. A medical device for preparing a haemostatic paste, consisting of: i) a containment unit defining a first internal volume and being comprised of a material impermeable to a fluid, wherein the containment unit further comprises an opening to an external environment and a closure-unit for closing t
1. A medical device for preparing a haemostatic paste, consisting of: i) a containment unit defining a first internal volume and being comprised of a material impermeable to a fluid, wherein the containment unit further comprises an opening to an external environment and a closure-unit for closing the opening,wherein the opening is re-closable with the at least one closure-unit, andii) a sterile haemostatic agent in powder form contained in said containment unit and having a second volume of less than 90% of the first internal volume of the containment unit; wherein said sterile haemostatic agent is capable of forming a putty-like paste in the presence of a third volume of liquid; andiii) an outer packaging defining a sterile barrier seal enclosing said containment unit; wherein the remaining volume of at least 10% of the internal volume is a void volume allowing for the addition of a third volume of liquid from an external environment to the sterile haemostatic agent in powder form through the opening and mixing of the sterile haemostatic agent in powder form and the added liquid within the containment unit without present exposure to an environment external to that of the containment unit. 2. The medical device according to claim 1, wherein the at least one opening is separated from said external environment by the closure-unit during the mixing. 3. The medical device according to claim 1, wherein said haemostatic agent in powder form is gelatine. 4. The medical device according claim 1, wherein said haemostatic agent in powder form is collagen. 5. The medical device according to claim 1, wherein the volume of said haemostatic agent is less than 80% of the internal volume of the containment unit. 6. The medical device according to claim 1, wherein said haemostatic agent is provided in an amount from about 0.5 to 5 g. 7. The medical device according to claim 1, wherein the haemostatic agent is provided in an amount of about 1 g, and the volume of the containment unit is 50 to 100 cubic centimetres. 8. The medical device according to claim 1, wherein said containment unit is rigid or semi-rigid and comprises a wide-mouth opening. 9. The medical device according to claim 8, wherein said containment unit and closure unit is made of a material selected from the group of polypropylene, polyethylene, PVC and PET. 10. The medical device according to claim 9, wherein the containment unit is made from substantially rigid polyethylene or polypropylene, and has a single opening which may be sealed with a threaded, polyethylene or polypropylene closure. 11. The medical device according to claim 1, wherein said outer packaging comprises a laminated foil pouch. 12. A haemostatic kit comprising i) the medical device according to claim 1, andii) a third volume of a sterile liquid in a second containment unit whose internal volume is physically separated from the containment unit of the medical device,wherein the kit is suitable for adding said liquid to said containment unit of the medical device. 13. The haemostatic kit according to claim 12, wherein said third volume of liquid is selected from the group of water, an aqueous solution, saline, an aqueous solution comprising an isotonicity-adjusting agent, an aqueous solution comprising thrombin and/or an aqueous solution comprising a bacteriostatic agent. 14. A process for preparing a haemostatic paste comprising the steps of: A) removing the outer packaging of the medical device according to claim 1,B) opening the containment unit to the external environment,C) adding a sterile liquid to said containment unit,D) re-closing the at least one opening of the containment unit by the closure-unit, andE) mixing the liquid and the sterile haemostatic agent contained in the containment unit without substantial exposure of said haemostatic agent and said liquid to an environment external to the containment unit, thereby preparing the haemostatic paste. 15. The process according to claim 14, wherein said sterile liquid of step C) is added by pouring the liquid through the at least one opening of the containment unit. 16. The process according to claim 14, wherein said mixing of step E) is performed by shaking the containment unit. 17. The process according to claim 14, wherein the containment unit is transferred into a sterile field before opening said containment unit in step B). 18. The process according to claim 14, wherein the sterile liquid of step C) is added in a volume less than 35% of the second volume of haemostatic agent. 19. The process according to claim 14, wherein the haemostatic paste of step E) is a putty-like paste.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (101)
Ashton Gregory (Markham OH CAX) Cooper John T. (West Chester OH) Hawkins Craig A. (Toronto CAX), Absorbent core having improved dry/wet integrity.
Sadozai, Khalid K.; Kuo, Jing-wen; Sherwood, Charles H., Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers.
Epstein Gordon H. ; Lempert Todd E. ; Martin Brian B., Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method.
Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Hopkinton MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Bru, Collagen wound healing matrices and process for their production.
Pfeifer Thomas,DEX ; Weitzel Dietmar,DEX ; Kneip Wolfgang,DEX ; Vohwinkel Bernhard,DEX ; von Brand Axel,DEX, Component mixing apparatus and system including a movable cannula.
Donald G. Wallace ; George H. Chu ; Jacqueline Anne Schroeder, Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
Yannas Ioannis V. (Newtown Center MA) Gordon Philip L. (Lexington MA) Huang Chor (Avon Lake OH) Silver Frederick H. (Danville NH) Burke John F. (Belmont MA), Crosslinked collagen-mucopolysaccharide composite materials.
Haynes Duncan H (4051 Barbarossa Ave. Miami FL 33133) Bodeker Ben H. (3925 Dunes Way Burtonsville MD 20866) Kline Mark D. (11403 Ashley Dr. Rockville MD 20852), Drug releasing surgical implant or dressing material.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Illum Lisbeth (Nottingham GBX), Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving mater.
Yves Delmotte BE; Arnold Bilstad ; David Amrani ; James DiOrio ; Atif M. Yardimci ; David W. Pennington ; James S. Slepicka ; Cristina Stadler, Fibrin delivery device and method for forming fibrin on a surface.
Hashimoto, Masamichi; Umeda, Toshihiko; Arai, Kazuhiko; Miyata, Yoshiaki; Yamamoto, Osamu; Himeda, Yasukazu, Hyaluronic acid gel composition, process for producing the same, and medical material containing the same.
Yoshiaki Miyata JP; Akio Okamoto JP; Masatoshi Kawata JP; Kazuhiro Oshima JP; Masamichi Hashimoto JP; Kazuhiko Arai JP; Tomio Sawada JP, Hyaluronic acid gel, a method of its production and medical material containing it.
Harvey Michael A. ; Kremer Richard D. ; Burghoff Robert L. ; King Thomas H., Methods and devices for collecting and storing clinical samples for genetic analysis.
Sawyer Philip N. (Brooklyn NY) Sawyer Philip M. (Menlo Park CA) Reich Cary J. (Laguna Hills CA), Methods for sealing of staples and other fasteners in tissue.
Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
Nabai Hossein (14555 Levan Rd. ; Suite 410 Livonia MI 48154) Rahbari Homayoon (1314 N. Macomb St. ; P.O. Box 360 Monroe MI 48161), Skin biopsy plug and method.
Perbellini Alberto (Padua ITX) Toffano Gino (Montegrotto Terme ITX) Romeo Aurelio (Rome ITX), Spongy material consisting essentially of hyaluronic acid or its derivatives, and its use in microsurgery.
Trevino Leo A. ; Schutt Ernest George ; Klein David H. ; Tarara Thomas E. ; Weers Jeffry G. ; Kabalnov Alexey, Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement.
Kuo Jing-Wen (Stoneham MA) Swann David A. (Lexington MA) Prestwich Glenn D. (Harbor NY), Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH), Weighted collagen microsponge for immobilizing bioactive material.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH), Weighted collagen microsponge for immobilizing bioactive material.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH) Maffia Gennaro J. (Leba, Weighted collagen microsponge for immobilizing bioactive materials.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.