[특허]Method for screening neurogenic agents

[미국특허] Method for screening neurogenic agents 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/567
출원번호	US-0852922 (2007-09-10)
등록번호	US-8293488 (2012-10-23)
발명자 / 주소	Kelleher-Andersson, Judith Johe, Karl K.
출원인 / 주소	Neuralstem, Inc.
대리인 / 주소	Morrison & Foerster LLP
인용정보	피인용 횟수 : 0 인용 특허 : 29

초록 ▼

A method for discovering neurogenic drugs is revealed. The method allows for systematic screening of test agents such as libraries of compounds. The method consists of exposing test agents to cultures of differentiating neural progenitor cells and measuring their effects on increasing the overall ce

대표청구항 ▼

1. A method of identifying a neurogenic agent, which comprises: (a) providing a stable human neural progenitor cell line, wherein (i) the cell line is derived from the hippocampus,(ii) the cell line has been expanded for at least ten cell doublings without substantially differentiating, and(iii) the cell line is capable of generating at least 40% neurons upon differentiation by mitogen withdrawal;(b) plating undifferentiated cells of said cell line into a culture with a serum-free, mitogen-free medium;(c) contacting the cells with a test agent which is a fused imidazole, an aminopyrimidine, a nicotinamide, an aminomethyl phenoxypiperidine or an aryloxypiperidine;(d) incubating the cells in the presence of the test agent for 3-7 days;(e) quantitatively determining the formation of neurons from said cells; andidentifying the test agent as a neurogenic agent if said test agent increases the number or proportion of neurons by at least ten percent (10%). 2. The method of claim 1, wherein the cell line comprises a genetic modification to enhance the mitotic capacity of the cells. 3. The method of claim 2, wherein the genetic modification includes inducing overexpression of a c-myc protein fused to a ligand-binding domain of estrogen receptor.

이 특허에 인용된 특허 (29) 인용/피인용 타임라인 분석

Kung, Hank F.; Kung, Mei-Ping; Zhuang, Zhi-Ping, Amyloid plaque aggregation inhibitors and diagnostic imaging agents.
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Edmondson, Scott D.; Fisher, Michael H.; Kim, Dooseop; Maccoss, Malcolm; Parmee, Emma R.; Weber, Ann E.; Xu, Jinyou, Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes.
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Bernard Ora (North Balwyn AUX) Bartlett Perry F. (North Carlton AUX), Generation of neural precursor cell lines.
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Anderson David J. (Altadena CA) Stemple Derek L. (Newton MA), Immoralized neural crest stem cells and methods of making.
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Johe Karl K., In vitro generation of differentiated neurons from cultures of mammalian multipotential CNS stem cells.
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Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny.
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Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vitro growth and proliferation of multipotent neural stem cells and their progeny.
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Anderson David J. ; Stemple Derek L., In vitro method for obtaining an isolated population of mammalian neural crest stem cells.
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Williams Robert L. (Warrndyte AUX) Gough Nicholas M. (North Balwyn AUX) Hilton Douglas J. (Warrandyte AUX), In vitro propagation of embryonic stem cells.
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Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vivo genetic modification of growth factor-responsive neural precursor cells.
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Sagen Jacqueline (6724 N. Rockwell St. Chicago IL 60645) Perlow Mark (1253 Fitzgerald Dr. Munster IN 46321) Pappas George D. (506 W. Roscoe St. Chicago IL 60657) Pollard Harvey B. (11008 Lamplighter , Inducing analgesia by implantation of cells releasing neuroactive substances.
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Johe Karl K., Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mam.
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Anderson David J. ; Stemple Derek L., Mammalian multipotent neural stem cells.
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Anderson David J. ; Stemple Derek L., Mammalian multipotent neural stem cells.
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Anderson David J. (Altadena CA) Stemple Derek L. (Pasadena CA), Mammalian neural crest stem cells.
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Sagen Jacqueline (2509 W. Farwell Chicago IL 60645) Sortwell Caryl E. (4548 N. Sheridan Chicago IL 60640) Pappas George D. (506 W. Roscoe St. Chicago IL 60657), Method for alleviating depression.
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Bowen David C. ; Johe Karl K., Method for generating dopaminergic cells derived from neural precursors.
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Gage Fred H. (La Jolla CA) Rosenberg Michael B. (San Diego CA) Friedmann Theodore (La Jolla CA), Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system.
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Szabo, Csaba; Jagtap, Prakash; Southan, Garry; Salzman, Andrew, Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives.
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Weiss,Samuel; Reynolds,Brent; Hammang,Joseph P.; Baetge,E. Edward, Methods of screening biological agents.
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Anderson David J. (Altadena CA) Stemple Derek L. (Newton MA), Neural chest stem cell assay.
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Samuel Weiss CA; Brent Reynolds CA; Joseph P. Hammang ; E. Edward Baetge, Neural transplantation using proliferated multipotent neural stem cells and their progeny.
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Luskin Marla B., Neuronal progenitor cells and uses thereof.
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Lee Virginia (Philadelphia PA) Pleasure Samuel (Philadelphia PA), Preparation of pure cultures of post-mitotic human neurons.
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Boss Barbara D. (Alameda CA) Spector Dennis H. (Oakland CA), Proliferated neuron progenitor cell product and process.
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Gage Fred H. ; Ray Jasodhara ; Hoshimaru Minoru,JPX, Regulatable retrovirus system for genetic modification of cells.
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Carpenter,Melissa K.; Denham,Jerrod J.; Inokuma,Margaret S.; Thies,R. Scott, Screening small molecule drugs using neural cells differentiated from human embryonic stem cells.
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Wilson Elaine L. (New York NY) Gabrilove Janice (New York NY), Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors.
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Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents.
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[미국특허] Method for screening neurogenic agents 원문보기