IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0873751
(2007-10-17)
|
등록번호 |
US-8293530
(2012-10-23)
|
발명자
/ 주소 |
- Burgess, James E.
- Campbell, Phil G.
- Weiss, Lee E.
- Smith, Jason
|
출원인 / 주소 |
- Carnegie Mellon University
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
13 인용 특허 :
70 |
초록
▼
A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form
A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form a final bioplastic construct.
대표청구항
▼
1. A method for making a plasma based plastic comprising: a) collecting a quantity of plasma, wherein said plasma is separated from whole blood; b) clotting said plasma; c) drying said clotted plasma, wherein said drying comprises lyophilization; d) contacting a quantity of the clotted dried plasma
1. A method for making a plasma based plastic comprising: a) collecting a quantity of plasma, wherein said plasma is separated from whole blood; b) clotting said plasma; c) drying said clotted plasma, wherein said drying comprises lyophilization; d) contacting a quantity of the clotted dried plasma with at least one plasticizer to make a dough; and e) shaping and heating said dough to make a bioplastic article. 2. The method according to claim 1, wherein at least one plasticizer is added to said quantity of plasma either before or after the step of clotting said plasma. 3. The method according to claim 1, wherein a crosslinking agent is added to said quantity of plasma either before or after the step of clotting said plasma. 4. The method according to claim 1, wherein said quantity of plasma is a pooled quantity of plasma from a plurality of mammalian donors and wherein a crosslinking agent is added to said quantity of plasma either before or after the step of clotting said plasma. 5. The method according to claim 1, wherein said quantity of plasma is a pooled quantity of plasma from a plurality of human donors. 6. The method according to claim 1, wherein said quantity of plasma is collected from a single human donor. 7. A method for making a plasma based plastic comprising: a) collecting a quantity of human plasma, wherein said plasma is separated from whole blood; b) clotting said plasma; c) drying said clotted plasma, wherein said drying comprises lyophilization; d) contacting a quantity of the clotted dried plasma with at least one plasticizer to make a dough; and e) shaping and heating said dough to make a bioplastic article. 8. The method according to claim 1 or 7, wherein said dough is heated at a temperature between 55-65° C. 9. The method according to claim 1 or 7, wherein said dough is heated at a temperature of no higher than 150° C. 10. The method according to claim 1 or 7, wherein the dough is shaped and heated at a pressure between 9-25 kilopounds per square inch. 11. The method according to claim 1 or 7, wherein the dough is shaped and heated at a pressure of at least 10.7 kilopounds per square inch or higher. 12. The method according to claim 1 or 7, wherein a porogen compound is added to the dough prior to shaping and heating. 13. The method according to claim 1 or 7, wherein said plasma is collected via apheresis. 14. The method according claim 1 or 7, wherein said plasma is whole plasma. 15. The method according to claim 1 or 7, wherein said plasma is platelet-rich plasma or platelet-poor plasma. 16. The method according to claim 1 or 7, wherein said plasma is plasma from which one or more constitutents has been removed. 17. The method according to claim 1 or 7 wherein the at least one plasticizer is selected from the group consisting of glycerol and water. 18. The method according to claim 1 or 7 wherein a stabilizer is added to said quantity of plasma and wherein said stabilizer is selected from the group consisting of glycogen, sorbitol, mannitol, trehalose, maltitol, xylitol, isomaltitol, erythritol, amylase, amylopectin, inositol hexasulphate, sulphated beta-cyclodextran, and combinations thereof. 19. The method according to claim 1 or 7 wherein the dough is crosslinked by adding genipin as a powder to the clotted dried plasma in the amount of about 2% by weight of the dried plasma. 20. The method according to claim 19 wherein said genipin is solubilized in alcohol before adding said genipin to the dough. 21. The method according to claim 1 or 7 wherein the clotted dried plasma is adjusted to a percentage water by weight of 5-15%. 22. The method according to claim 1 or 7 wherein ammonium acetate is added to the dough prior to shaping and heating. 23. The method according to claim 1 or 7 wherein prior to shaping and heating, the dough is combined with a quantity of particulate ammonium acetate crystals, pre-sized to 150-250 microns, and wherein during the shaping and heating the ammonium acetate crystals sublimate to result in a controlled porous plastic with a pore size of 150-250 microns. 24. The method according to claim 1 or 7 wherein said quantity of plasma is clotted, dried and comminuted to a particle size distribution of between 38-500 microns. 25. The method according to claim 1 or 7 wherein the dough is heated at a temperature between 100-140° C. 26. The method according to claim 1 or 7 wherein prior to shaping and heating, up to 10% nanoparticulate tricalcium phosphate is added to the dough.
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