IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0685655
(2010-01-11)
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등록번호 |
US-8295912
(2012-10-23)
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발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
124 인용 특허 :
266 |
초록
▼
In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive age
In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.
대표청구항
▼
1. A method of inhibiting a function of a a plexus of autonomic nerves traveling with an artery comprising: providing an external detecting device to detect a location of the artery of a patient, wherein the location of the artery is expressed in a first three dimensional coordinate reference frame;
1. A method of inhibiting a function of a a plexus of autonomic nerves traveling with an artery comprising: providing an external detecting device to detect a location of the artery of a patient, wherein the location of the artery is expressed in a first three dimensional coordinate reference frame;placing a therapeutic energy source in the first three dimensional coordinate reference frame;modeling a delivery of energy to regions on at least two sides of the artery where the autonomic nerves travel to determine a power level for the therapeutic energy source, wherein the act of modeling considers heat transfer due to blood flow in the artery; anddelivering therapeutic energy from the therapeutic energy source, through a skin of the patient, to the regions on the at least two sides of the artery, wherein the act of delivering the therapeutic energy is based on a result from the act of modeling;wherein the delivered therapeutic energy at least partially inhibits the function of the autonomic nerves traveling with the artery. 2. The method of claim 1 wherein the therapeutic energy is ultrasound. 3. The method of claim 1 wherein the artery is a renal artery. 4. The method of claim 1 wherein the artery is located using a doppler ultrasound signal. 5. The method of claim 1, wherein the detecting device is configured to detect the location of the artery by detecting a position of a reference location in the artery using a fiducial, wherein the fiducial is placed internal to the patient, and wherein the act of delivering is performed based on the detected position of the reference location. 6. The method of claim 5 wherein said fiducial is a catheter placed in the artery of the patient. 7. The method of claim 6 wherein said catheter is detectable using a radiofrequency signal. 8. The method of claim 1 wherein the therapeutic energy from the energy source is delivered in a distribution along a length of the artery. 9. The method of claim 1 wherein the therapeutic energy is ionizing radiation. 10. The method of claim 1, wherein the therapeutic energy comprises low intensity ultrasound. 11. The method of claim 1, wherein at least one of the regions comprises an adventitial region of the artery. 12. The method of claim 1, wherein at least one of the regions is adjacent to the artery. 13. The method of claim 1, wherein the therapeutic energy is delivered to a first nerve fiber at a first one of the regions on a first one of the at least two sides of the artery, and to a second nerve fiber at a second one of the regions on a second one of the at least two sides of the artery. 14. A system to inhibit a function of a nerve traveling with a renal artery comprising: a detector to determine a location of the renal artery from a position external to a patient;an ultrasound component to deliver therapeutic energy through a skin of the patient from at least two directions to the nerve surrounding the renal artery; anda modeling algorithm configured to receive the location of the renal artery in a three dimensional coordinate space and a position of the ultrasound component in the three dimensional coordinate space, and determine the directions and energy level of the therapeutic energy using the location of the renal artery and the position of the ultrasound component wherein the modeling algorithm considers heat transfer due to blood flow in the renal artery, and wherein the modeling algorithm is configured to generate an output for operating the ultrasound component to create multiple lesions around the renal artery. 15. The system of claim 14, further comprising a fiducial, locatable by the detector from a position outside the patient, adapted to be temporarily placed in the renal artery of the patient. 16. The system of claim 15, wherein the fiducial is a passive reflector of ultrasound. 17. The system of claim 15, wherein the fiducial generates radiofrequency energy. 18. The system of claim 15, wherein the fiducial is activated to transmit energy based on a signal from an ultrasound or magnetic field generator. 19. The system of claim 14 wherein the modeling algorithm is configured to generate the output for operating the ultrasound component to create the lesions around the artery in which a major axis of at least one of the lesions is longitudinal along a length of the artery. 20. The system of claim 19 wherein the lesions are around the renal artery just proximal to a bifurcation of the renal artery in a hilum of a kidney. 21. The system of claim 14 wherein the modeling algorithm is configured to generate the output for operating the ultrasound component to create a circumferential lesion formed by the multiple lesions around the renal artery. 22. A method of inhibiting nerve function, comprising: placing a therapeutic energy source in a three dimensional coordinate space that is external to a patient;delivering first therapeutic energy from the therapeutic energy source, through a skin of the patient, to a first region on a first side of the artery; anddelivering second therapeutic energy from the therapeutic energy source, through the skin of the patient, to a second region on a second side of the artery;wherein the delivered first therapeutic energy at least partially inhibits a function of a first nerve fiber in the first region;wherein the delivered second therapeutic energy at least partially inhibits a function of a second nerve fiber in the second region; andwherein the method further comprises applying a model of tissue heating that accounts for a convective heat transfer to model heat transfer due to blood flow through the artery, and a conductive heat transfer to model heat transfer from the therapeutic energy source through tissue in a region of the artery, to calculate power and phase for the therapeutic energy source to produce a desired degree of heating of the first nerve fiber. 23. The method of claim 22, wherein the therapeutic energy comprises low intensity ultrasound. 24. The method of claim 22, wherein the first region comprises an adventitial region of the artery. 25. The method of claim 22, wherein the first region is adjacent to the artery. 26. The method of claim 22, wherein the therapeutic energy is ultrasound. 27. The method of claim 22, wherein the artery is a renal artery. 28. The method of claim 22, further comprising: determining a position of a reference location in the artery using a fiducial, wherein the fiducial is placed internal to the patient, and wherein the act of delivering the first therapeutic energy is performed based on the determined position of the reference location. 29. The method of claim 28, wherein the fiducial is at a catheter placed in the artery of the patient. 30. The method of claim 29, wherein the catheter is detectable using a radiofrequency signal. 31. The method of claim 22, wherein the first therapeutic energy from the energy source is delivered in a distribution along a length of the artery.
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