초록 ▼

The present invention concerns sample pick-up and metering devices, analytical test systems for determining an analyte in a sample liquid and their use for this purpose and methods for determining an analyte in a sample liquid. They comprise or use a sample pick-up and metering device according to t

The present invention concerns sample pick-up and metering devices, analytical test systems for determining an analyte in a sample liquid and their use for this purpose and methods for determining an analyte in a sample liquid. They comprise or use a sample pick-up and metering device according to the invention which consists of a support and a metering element integrated into the support for taking up a defined volume of sample liquid and a closed liquid compartment located on the support which contains a defined volume of a liquid where the liquid compartment on the support can be opened.

대표청구항 ▼

1. A method for determining an analyte in a liquid sample comprising: a) providing an analytical test system comprising: a sample pick-up and metering device comprising: a metering element that picks up and retains a defined volume of the liquid sample,a support which contains at least one closed li

1. A method for determining an analyte in a liquid sample comprising: a) providing an analytical test system comprising: a sample pick-up and metering device comprising: a metering element that picks up and retains a defined volume of the liquid sample,a support which contains at least one closed liquid compartment in which a defined volume of a liquid is contained, wherein the support, the liquid compartment, and the metering element form one constructional unit, andthe metering element is fixedly connected to the support, anda reaction cuvette;b) contacting the metering element with the liquid sample to be analyzed such that the defined volume of the liquid sample remains in the metering element;c) introducing the sample pick-up and metering device into the reaction cuvette;d) opening at least one liquid compartment on the support such that the liquid contained in this liquid compartment flows into the reaction cuvette and comes there into contact with the liquid sample contained in the metering element in such a manner that the liquid sample from the metering element is provided in the reaction cuvette and a reaction mixture is formed; ande) determining the analyte on the basis of a characteristic measured quantity for the analyte. 2. The method according to claim 1 further comprising adding reagents for the determination of the analyte and/or intermixing the reaction mixture. 3. The method according to claim 1 further comprising determining the analyte on the basis of a characteristic measured quantity for the analyte by optical detection methods. 4. An analytical test system for determining an analyte in a liquid sample comprising: a support including a closed liquid compartment in which a defined volume of a liquid is contained, the liquid compartment being closed by a liquid-tight and gas-tight foil that can be pulled off or pierced, anda metering element including a capillary that picks up and retains a defined volume of the liquid sample; anda reaction cuvette defining a volume that receives the support;wherein the liquid compartment is configured to be opened to release the liquid contained in the liquid compartment into the reaction cuvette to mix with the liquid sample and facilitate analyte determination. 5. A sample pick-up and metering device comprising: a metering element; anda support which contains at least one closed liquid compartment in which a defined volume of a liquid is contained, wherein the metering element includes a capillary with two free openings that picks up and retains a defined volume of liquid sample and forms one constructional unit with the support and the liquid compartment, andthe liquid compartment is closed by a liquid-tight and gastight foil, which when pulled causes the defined volume of the liquid contained in the liquid compartment to come into contact and mix with the defined volume of liquid sample contained in the metering element. 6. The sample pick-up and metering device according to claim 5, wherein the support is configured such that after opening the liquid compartment, the liquid contained in the liquid compartment comes into contact with and is mixed with the defined volume of the liquid sample contained in the metering element. 7. The sample pick-up and metering device according to claim 5, wherein at least one liquid contained in the liquid compartment is a buffer solution or diluent solution or a reagent solution. 8. The sample pick-up and metering device according to claim 5, wherein two or more liquid compartments that are separate from one another are present on the support. 9. The sample pick-up and metering device according to claim 8, wherein said compartments are opened simultaneously or sequentially. 10. An analytical test system for determining an analyte in a liquid sample comprising: a sample pick-up and metering device according to claim 5, anda reaction cuvette. 11. The analytical test system according to claim 10 further comprising a mixing device. 12. The analytical test system according to claim 10, wherein the reaction cuvette contains one or more devices which enable a determination of the analyte in the reaction cuvette. 13. The analytical test system according to claim 10, wherein the specific reagent liquids required to determine the analyte are contained in one or more liquid compartments on the support of the sample pick-up and metering device. 14. The analytical test system according to claim 10, wherein the specific reagents required to determine the analyte are contained in the reaction cuvette. 15. The analytical test system according to claim 14, wherein said reagents are in a dry chemistry form. 16. The analytical test system according to claim 10, wherein the analyte is determined by sequential detection reactions. 17. The analytical test system according to claim 10, wherein the analyte is haemoglobin A1 c and said liquid sample is blood.