초록 ▼

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.

대표청구항 ▼

1. A method of ablating cardiac tissue, the method comprising: providing a tissue ablation device including a plurality of ablating elements and at least one adjustment structure coupled to at least one of the plurality of ablating elements;placing the tissue ablation device in a first position on a

1. A method of ablating cardiac tissue, the method comprising: providing a tissue ablation device including a plurality of ablating elements and at least one adjustment structure coupled to at least one of the plurality of ablating elements;placing the tissue ablation device in a first position on an epicardial surface;activating the at least one of the plurality of ablating elements at least once to emit ultrasonic energy focused in at least one dimension towards tissue to be ablated; andadjusting the at least one adjustment structure, wherein movement of the adjustment structure physically moves at least one of the plurality of ablating elements relative to the tissue, and wherein movement of the at least one of the plurality of ablating elements moves a focus of the ultrasonic energy emitted by the at least one of the plurality of ablating elements into at least one preset position relative to the tissue to be ablated without relocating the device from the first position on the epicardial surface. 2. The method according to claim 1, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure such that the focus of the ultrasonic energy is proximate an endocardial surface of the cardiac tissue. 3. The method according to claim 2, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure such that the focus of the ultrasonic energy is closer than about 1 mm to about 3 mm to the endocardial surface of the cardiac tissue. 4. The method according to claim 2, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure such that the focus of the ultrasonic energy is proximate the endocardial surface of the cardiac tissue and within a thickness of the cardiac tissue. 5. The method according to claim 2, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure such that the focus of the ultrasonic energy is proximate the endcoardial surface of the cardiac tissue and at least partially outside a thickness of the cardiac tissue within a blood pool. 6. The method according to claim 1, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure such that the focus of the ultrasonic energy is proximate an epicardial surface of the cardiac tissue. 7. The method according to claim 6, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure such that the focus is located within the innermost about 3 mm of endocardial tissue adjacent a blood pool. 8. The method according to claim 1, wherein the step of adjusting the at least one adjustment structure comprises adjusting the at least one adjustment structure to move a focus of the ultrasonic energy emitted by the at least one of the plurality of ablating elements into a plurality of positions relative to the tissue to be ablated, whereby a substantially continuous lesion is created in the cardiac tissue. 9. The method according to claim 8, wherein the substantially continuous lesion is a transmural lesion. 10. The method according to claim 8, wherein the adjusting step is carried out while the at least one of the plurality of ablating elements is actively ablating. 11. The method according to claim 8, wherein the adjusting step is carried out between activations of the at least one of the plurality of ablating elements. 12. The method according to claim 1, wherein the step of activating the at least one of the plurality of ablating elements to emit ultrasonic energy focused in at least one dimension comprises pulse-activating the at least one of the plurality of ablating elements to emit ultrasonic energy. 13. The method according to claim 12, wherein the step of pulse-activating the at least one of the plurality of ablating elements to emit ultrasonic energy comprises activating the at least one of the plurality of ablating elements for a pulse duration between about 0.1 seconds and about 1.5 seconds. 14. The method according to claim 13, wherein the pulse duration is between about 0.2 seconds and about 1.2 seconds. 15. The method according to claim 12, wherein the pulse duration is between about 0.25 seconds and about 1.0 seconds. 16. The method according to claim 12, wherein the step of pulse-activating the at least one of the plurality of ablating elements to emit ultrasonic energy comprises activating the at least one of the plurality of ablating elements to emit ultrasonic energy in short bursts. 17. The method according to claim 1, further comprising: monitoring a temperature of the cardiac tissue; andadjusting one or more properties of the at least one of the plurality of ablating elements to maintain the monitored temperature of the cardiac tissue below a preset threshold temperature. 18. The method according to claim 17, wherein the preset threshold temperature is about 100 degrees C. 19. A method of epicardially ablating cardiac tissue, the method comprising: providing a tissue ablation device including at least one ablating element;acoustically coupling the tissue ablation device to an epicardial surface of a heart; andactivating the at least one ablating element a first time at a first frequency for a first duration and a second time at a second frequency for a second duration to emit ultrasonic energy focused in at least one dimension towards cardiac tissue to be ablated, wherein the second duration is longer than the first duration,wherein a focus of the ultrasonic energy emitted by the at least one ablating element is located proximate the endocardium, such that a lesioning temperature can be attained proximate an interface between an endocardial surface and a cardiac blood pool. 20. The method according to claim 19, wherein the step of acoustically coupling the tissue ablation device to an epicardial surface of a heart comprises acoustically coupling the tissue ablation device to the epicardial surface of the heart across an intermediate acoustic standoff. 21. The method according to claim 19, wherein the focus of the ultrasonic energy emitted by the at least one ablating element is movable relative to the at least one ablating element by varying one or more ablating element driving parameters. 22. The method according to claim 19, wherein the focus of the ultrasonic energy emitted by the at least one ablating element is movable relative to the tissue to be ablated by varying a spatial state of the at least one ablating element without acoustically decoupling the tissue ablation device from the epicardial surface of the heart. 23. The method according to claim 19, wherein the second frequency is greater than the first frequency. 24. A method of ablating cardiac tissue, the method comprising: providing a tissue ablation device including a plurality of ablating elements, at least one of the ablating elements having an ablation energy deposition behavior versus tissue depth that can be depth-adjusted via a change in an operating parameter of the at least one ablating element;acoustically coupling the tissue ablation device to cardiac tissue to be ablated; andactivating the at least one ablating element at two or more states of the operating parameter, wherein the at least one ablating element is activated a first time at a first frequency for a first duration and a second time at a second frequency for a second duration, wherein the second duration is longer than the first duration, thereby delivering the ablation energy at two or more depths in the cardiac tissue to be ablated. 25. The method according to claim 24, wherein the plurality of ablating elements comprises a plurality of ultrasonic transducers. 26. The method according to claim 25, wherein the operating parameter is ultrasonic frequency. 27. The method according to claim 24, wherein the plurality of ablating elements comprises a plurality of laser ablating elements. 28. The method according to claim 27, wherein the operating parameter is laser wavelength.