IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0308818
(2007-05-11)
|
등록번호 |
US-8317389
(2012-11-27)
|
우선권정보 |
DE-10 2006 030 056 (2006-06-29) |
국제출원번호 |
PCT/EP2007/004187
(2007-05-11)
|
§371/§102 date |
20090925
(20090925)
|
국제공개번호 |
WO2008/000312
(2008-01-03)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
9 인용 특허 :
9 |
초록
▼
A microtiter plate (1), which can be used in a device G, comprises a plurality of receptacles (2) disposed next to one another for a substance or fluid to be stirred and analyzed, wherein stirring rods (3) are provided for stirring. So as to drive these stirring rods, it is provided that the bottoms
A microtiter plate (1), which can be used in a device G, comprises a plurality of receptacles (2) disposed next to one another for a substance or fluid to be stirred and analyzed, wherein stirring rods (3) are provided for stirring. So as to drive these stirring rods, it is provided that the bottoms (4) of the individual receptacles (2) are displaceable and deflectable and that a stirring rod (3) penetrates each of them centrally, the rod being seized by a drive on an outer section (3b) protruding downward beyond the bottom (4) such that it can be set into a back and forth motion or a gyrating or rotary motion and thus continues the desired stirring motion on the inside of the receptacle (2).
대표청구항
▼
1. A microtiter plate (1), comprising a plurality of receptacles (2), located side by side, for receiving substances to be mixed and/or stirred and examined, and having stirring elements, and one of the stirring elements is located in individual ones of the receptacles or all the receptacles above t
1. A microtiter plate (1), comprising a plurality of receptacles (2), located side by side, for receiving substances to be mixed and/or stirred and examined, and having stirring elements, and one of the stirring elements is located in individual ones of the receptacles or all the receptacles above their base (4), and having a drive mechanism (5) for the stirring elements, the bases (4) of the receptacles (2) in the microtiter plate (1) are resilient and/or deformable; and as the stirring element, a stirring rod (3) at least one of joined to the respective base (4) or penetrating the respective base (4) is provided, a first portion (3a) of the stirring rod (3) extends from the base (4) of the receptacle (2) into an interior thereof and a second portion (3b) of the stirring rod (3) extends from the base (4) to outside the receptacle (2); and in a position for use, the second portion (3b), located outside the receptacle (2), of the stirring rod (3) is acted upon by the drive mechanism (5). 2. The microtiter plate as defined by claim 1, wherein the bases (4) of the individual receptacles (2) are embodied at least one of resiliently or as movable diaphragms by at least one of a material weakening or by selection of the material forming the bases (4). 3. The microtiter plate as defined by claim 1, wherein the stirring rods (3) are at least one of adjoined in one piece or in clamping fashion or by positive engagement to the bases (4). 4. The microtiter plate as defined by claim 1, wherein the second portions (3b) of the stirring rods (3) are acted upon by the drive mechanism (5) and are drivable synchronously. 5. The microtiter plate as defined by claim 1, wherein the second portions (3b) of the stirring rods (3) include ends, and each of the ends engage one recess in a drive element connected to the drive mechanism that is movable at least one of back and forth or in a circle relative to the receptacles (2) parallel to the microtiter plate (1). 6. The microtiter plate as defined by claim 5, wherein as the drive element for common driving of the stirring rods (3), a drive plate (6) located in a horizontal plane parallel to the underside of the microtiter plate (1) is provided, having perforations which are engaged by the second portions (3b), located outside the receptacles (2), of the stirring rods (3), and in use, a parallel relative motion between the drive plate (6) and the microtiter plate (1) is provided. 7. The microtiter plate as defined by claim 6, wherein the drive plate (6) is movable relative to the microtiter plate (1) in a closed path or in a circle; and the movable base (4) of the individual receptacles (2) centers the stirring rods (3) in such a manner that an apex of tumbling motions thereof is located in the base (4). 8. The microtiter plate as defined by claim 6, wherein the drive plate (6) that has the perforations (7), is stationary, and the microtiter plate (1) is movable relative to the drive plate (6) back and forth or in circles. 9. The microtiter plate as defined by claim 6, wherein the perforations (7) of the drive plate (6) are embodied as tapering conically down to a minimum dimension in an insertion direction of the stirring rods (3), so that the respective stirring rod fits with the end of the second portion into the minimum dimension of the drive perforation (7), and the tapering of the perforation (7) is embodied with an obliquity that corresponds to or exceeds an oblique deflection of the stirring rod (3). 10. The microtiter plate as defined by claim 6, wherein during the stirring motions, the microtiter plate (1) is stationary and the drive plate (6) is movable parallel to the microtiter plate. 11. The microtiter plate as defined by claim 1, wherein a length and a deflection of the second portion (3b) of the stirring rods (3) by the drive mechanism are selected such that the first portion (3a) of the stirring rods (3), during a stirring or tumbling motion thereof, is spaced apart from an inner wall of the receptacles (2). 12. The microtiter plate as defined by claim 1, wherein at least one of the base (4) or a diaphragm forming the base is at least one of retroactively mounted, molded or glued onto, or embodied in one piece with, the microtiter plate (1) and the stirring rods (3). 13. The microtiter plate as defined by claim 1, wherein at least one of the microtiter plate (1) or the stirring rods (3) and the bases (4) of the receptacles (2) comprise plastic. 14. The microtiter plate as defined by claim 1, wherein the receptacles (2) are provided with a reopenable closure (8), that closes all the receptacles or groups of the receptacles (2). 15. The microtiter plate as defined by claim 1, wherein a shaking drive is superimposed on the stirring drive. 16. The microtiter plate as defined by claim 1, wherein for shaking the microtiter plate provided with stirring rods, the drive for the stirring rods has an imbalance. 17. The microtiter plate as defined by claim 1, wherein the stirring rods (3) have matching dimensions. 18. The microtiter plate as defined by claim 1, wherein a length of the first portion (3a) of at least one or some or all of the stirring rods (3) is selected such that in the stirring motion, it touches an inner wall of the associated receptacle (2). 19. The microtiter plate as defined by claim 1, wherein at least a free end of the first portion (3a) of the stirring rod (3) is elastically flexible and can be pressed over at least part of a length thereof against an inner wall of the associated receptacle (2). 20. The microtiter plate as defined by claim 1, wherein at least the second portion (3b) of the stirring rod (3) is rigid and has a larger cross section than the free end of the first portion (3a). 21. The microtiter plate as defined by claim 1, wherein an end near the base (4) of the first portion (3a) of the stirring rod or rods (3) has a larger cross section than a free, flexible end thereof; and the flexible end of the first portion (3a) is longer than an end near the base (4).
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