A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that
A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.
대표청구항▼
1. A disposable cassette configured for operative association with a base unit to replace a volume of a first liquid with a substantially equal volume of a second liquid, the disposable cassette comprising: the first fluid flow network for the first liquid and the second fluid flow network for the s
1. A disposable cassette configured for operative association with a base unit to replace a volume of a first liquid with a substantially equal volume of a second liquid, the disposable cassette comprising: the first fluid flow network for the first liquid and the second fluid flow network for the second liquid, the first fluid flow network comprising an inlet port and an outlet port for the first liquid, and the second fluid flow network comprising an inlet port and an outlet port for the second liquid;a first balancing pod and a second balancing pod, each balancing pod separated into a first chamber and a second chamber by a flexible membrane configured to provide a seal between the first chamber and the second chamber, wherein the first chamber is in fluid communication with the first fluid flow network and the second chamber is in fluid communication with the second fluid flow network; the first chamber of each of the first and second balancing pods having at least one first chamber balancing pod port for ingress and/or egress of the first liquid, each at least one first chamber balancing pod port in fluid communication with a valve to permit a fluid flow between the first chamber and the inlet port of the first fluid flow network, and in fluid communication with a valve to permit a fluid flow between the first chamber and the outlet port of the first fluid flow network, and;the second chamber of each of the first and second balancing pods having at least one second chamber balancing pod port for ingress and/or egress of the second liquid, each at least one second chamber balancing pod port in fluid communication with a valve to permit a fluid flow between the second chamber and the inlet port of the second fluid flow network, and in fluid communication with a valve to permit a fluid flow between the second chamber and the outlet port of the second fluid flow network; anda first reciprocating positive displacement membrane pump and a second reciprocating positive displacement membrane pump both in fluid communication with the second fluid flow network,the first reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the second fluid flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the first balancing pod;the second reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the second fluid flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the second balancing pod; wherein the disposable cassette can be operated by the base unit so thata first volume of the second liquid can be drawn through the inlet port of the second fluid flow network by the first reciprocating positive displacement membrane pump, stored in the first reciprocating positive displacement membrane pump, and pumped to the second chamber of the first balancing pod to displace the flexible membrane of the first balancing pod and move a first volume of the first liquid out of the first chamber of the first balancing pod to exit the cassette through the outlet port of the first fluid flow network, anda second volume of the second liquid can be drawn through the inlet port of the second fluid flow network by the second reciprocating positive displacement membrane pump, stored in the second reciprocating positive displacement membrane pump, and pumped to the second chamber of the second balancing pod to displace the flexible membrane of the second balancing pod and move a second volume of the first liquid out of the first chamber of the second balancing pod to exit the cassette through the outlet port of the first fluid flow network. 2. The disposable cassette of claim 1, wherein the first and second reciprocating positive displacement membrane pumps and each of the valves has a fluidic control port through which a fluid under a positive or a negative pressure can actuate each pump and each of the valves to permit directed movement of the first and the second liquids within the cassette. 3. The disposable cassette of claim 1, wherein the valves are pneumatically actuated fluid valves, and the cassette comprises a top plate, a middle plate and a bottom plate, the top plate defining the first fluid flow network for the first liquid and the second fluid flow network for the second liquid; the middle plate providing support for at least one flexible membrane; andthe bottom plate defining control chambers and fluidic control ports configured and positioned to operate the valves and the pumps. 4. The disposable cassette of claim 1, further comprising a metering pump, the metering pump comprising a metering pump inlet port in fluid communication through a metering inlet valve with the inlet port of the second fluid flow network, and a metering pump outlet port in fluid communication through a metering outlet valve with the outlet port of the second fluid flow network. 5. The disposable cassette of claim 4, wherein the metering pump is a reciprocating positive displacement membrane pump having an actuation chamber and a fluidic control port through which a fluid under a positive or a negative pressure can actuate the metering pump. 6. The disposable cassette of claim 5, wherein the metering pump is actuated by a pneumatic pressure or a vacuum, and the metering inlet valve and the metering outlet valve of said metering pump are pneumatically actuated fluid valves. 7. The disposable cassette of claim 1, wherein the at least one first chamber balancing pod port comprises a single port configured for both ingress and egress of the first liquid. 8. The disposable cassette of claim 1, wherein the at least one second chamber balancing pod port comprises a single port configured for both ingress and egress of the second liquid. 9. A disposable cassette configured for operative association with a base unit of a dialysis apparatus to replace a volume of a spent dialysate from a dialyzer with a substantially equal volume of a fresh dialysate, the disposable cassette comprising: a fresh dialysate flow network and a spent dialysate flow network, the fresh dialysate flow network comprising an inlet port and an outlet port for the fresh dialysate, and the spent dialysate flow network comprising an inlet port and an outlet port for the spent dialysate;a first balancing pod and a second balancing pod, each balancing pod separated into a first chamber and a second chamber by a flexible membrane configured to provide a seal between the first chamber and the second chamber, wherein the first chamber is in fluid communication with the fresh dialysate flow network and the second chamber is in fluid communication with the spent dialysate flow network; the first chamber of each of the first and second balancing pods having at least one first chamber balancing pod port for ingress and/or egress of the fresh dialysate, each at least one first chamber balancing pod port in fluid communication with a valve to permit fluid flow between the first chamber and the inlet port of the fresh dialysate flow network, and in fluid communication with a valve to permit fluid flow between the first chamber and the outlet port of the fresh dialysate flow network, and;the second chamber of each of the first and second balancing pods having at least one second chamber balancing pod port for ingress and/or egress of the spent dialysate, each at least one second chamber balancing pod port in fluid communication with a valve to permit fluid flow between the second chamber and the inlet port of the spent dialysate flow network, and in fluid communication with a valve to permit fluid flow between the second chamber and the outlet port of the spent dialysate flow network; anda first reciprocating positive displacement membrane pump and a second reciprocating positive displacement membrane pump, both in fluid communication with the spent dialysate flow network,the first reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the spent dialysate flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the first balancing pod;the second reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the spent dialysate flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the second balancing pod; whereinthe disposable cassette can be operated by the base unit so thata first volume of the spent dialysate can be drawn through the inlet port of the spent dialysate flow network by the first reciprocating positive displacement membrane pump, stored in the first reciprocating positive displacement membrane pump, and pumped to the second chamber of the first balancing pod to displace the flexible membrane of the first balancing pod and move a first volume of fresh dialysate out of the first chamber of the first balancing pod to exit the cassette through the outlet port of the fresh dialysate flow network, anda second volume of the spent dialysate can be drawn through the inlet port of the spent dialysate flow network by the second reciprocating positive displacement membrane pump, stored in the second reciprocating positive displacement membrane pump, and pumped to the secons chamber of the second balancing pod to displace the flexible membrane of the second balancing pod and move a second volume of fresh dialysate out of the first chamber of the second balancing pod to exit the cassette through the outlet port of the fresh dialysate flow network. 10. The disposable cassette of claim 9, further comprising an ultrafiltration metering pump, a metering inlet port of said ultrafiltration metering pump being in fluid communication through a valve with the inlet port of the spent dialysate flow network, and a metering outlet port of said ultrafiltration metering pump being in fluid communication through a valve with the outlet port of the spent dialysate flow network, wherein at least a portion of fluid flow lines in fluid communication with the ultrafiltration metering pump is separate from fluid lines of the cassette that communicate with the balancing pods, andthe ultrafiltration metering pump can be operated to bypass the balancing pods so that a pre-determined amount of the spent dialysate can be pumped from a dialyzer in fluid communication with the inlet port of the spent dialysate flow network through the cassette and to the outlet port of the spent dialysate flow network without being replaced by an equal amount of fresh dialysate. 11. The disposable cassette of claim 9, wherein the at least one first chamber balancing pod port comprises a single port configured for both ingress and egress of the fresh dialysate. 12. The disposable cassette of claim 9, wherein the at least one second chamber balancing pod port comprises a single port configured for both ingress and egress of the spent dialysate.
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