IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0109574
(2008-04-25)
|
등록번호 |
US-8317823
(2012-11-27)
|
발명자
/ 주소 |
- Pavcnik, Dusan
- Kaufman, John
- Fette, Clay D.
|
출원인 / 주소 |
- Cook Biotech Incorporated
|
대리인 / 주소 |
Woodard, Emhardt, Moriarty, McNett & Henry LLP
|
인용정보 |
피인용 횟수 :
3 인용 특허 :
66 |
초록
▼
An absorbable and expandable closure member used to occlude or exclude a body lumen or cavity, such as a blood vessel, fallopian tube, duct, aneurysmal sac, etc., comprising a closure member comprising one of more sheets of a biomaterial that are rolled, stacked, or folded to form a multilayer const
An absorbable and expandable closure member used to occlude or exclude a body lumen or cavity, such as a blood vessel, fallopian tube, duct, aneurysmal sac, etc., comprising a closure member comprising one of more sheets of a biomaterial that are rolled, stacked, or folded to form a multilayer construct of a generally cylindrical configuration for deployment through a delivery system, either as a singularly or part of a multiplicity of closure members. The biomaterial is derived from a source material, such as small intestinal submucosa or another remodelable material (e.g., an extracellular matrix) having properties for stimulating ingrowth of adjacent tissue into the biomaterial deployed within the bodily lumen. The closure member is deployed to the bodily lumen from a delivery sheath, cartridge, and/or over a inner guiding member, such as a wire guide or catheter.
대표청구항
▼
1. A method for plugging a bodily passageway, comprising: providing an implantable plug member suitable for delivery to the bodily passageway, wherein the passageway is a gastroenteric fistula, the implantable plug member having a first end and a second end and including one or more sheets of a bioc
1. A method for plugging a bodily passageway, comprising: providing an implantable plug member suitable for delivery to the bodily passageway, wherein the passageway is a gastroenteric fistula, the implantable plug member having a first end and a second end and including one or more sheets of a biocompatible extracellular matrix material harvested from collagenous-based mammalian tissue and processed to remove cells with the one or more sheets, prior to implantation, including adjacent layers contacting one another and providing biocompatible extracellular matrix material extending across the full width of the plug member for closing the bodily passageway with the biocompatible extracellular matrix material upon implantation, the extracellular matrix material, prior to implantation, forming an exposed outer surface of the plug member between said first end and said second end of the plug member and being effective upon implantation to stimulate angiogenesis and tissue ingrowth from adjacent native tissue such that the passageway becomes occluded with native tissue of the patient; anddelivering the plug member to the bodily passageway such that the plug member provides the biocompatible extracellular matrix material extending across the bodily passageway so as to close the passageway with the biocompatible extracellular matrix material. 2. The method of claim 1, wherein the biocompatible extracellular matrix material comprises small intestinal submucosa. 3. The method of claim 1, wherein the one or more sheets are configured to form a generally cylindrical construct. 4. The method of claim 3, wherein the one or more sheets are rolled and compressed to form the construct. 5. The method of claim 3, wherein the one or more sheets are folded and compressed to form the construct. 6. The method of claim 1, wherein the extracellular matrix material includes a lyophilized extracellular matrix material. 7. A method for plugging a bodily passageway, comprising: providing a plug member suitable for delivery to the bodily passageway, wherein the passageway is a gastroenteric fistula, the plug member including one or more sheets of a remodelable extracellular matrix material stabilized by compression to provide an implantable construct that, prior to implantation, includes adjacent layers of the one or more sheets contacting one another with the remodelable extracellular matrix material extending across the full width of the implantable construct for closing the bodily passageway with the remodelable extracellular matrix material upon implantation, the remodelable extracellular matrix material obtained in sheet form from a collagenous-based tissue source and effective to become infiltrated and replaced by native tissue upon implantation such that the bodily passageway generally becomes permanently occluded; anddelivering the plug member to the bodily passageway so that the plug member provides the remodelable extracellular matrix material extending across the bodily passageway so as to close the passageway with the remodelable extracellular matrix material. 8. The method of claim 7, wherein the one or more sheets are configured to form a generally cylindrical construct that includes the remodelable extracellular matrix material spanning the entirety of the length of the generally cylindrical construct. 9. The method of claim 8, wherein the one or more sheets are rolled and compressed to form the construct. 10. The method of claim 8, wherein the one or more sheets are folded and compressed to form the construct. 11. The method of claim 7, wherein the remodelable extracellular matrix material comprises small intestinal submucosa. 12. The method of claim 7, wherein the remodelable extracellular matrix material includes a lyophilized extracellular matrix material. 13. A method for closing a passageway in a body of a patient, comprising: providing an implantable construct suitable for delivery to the passageway, wherein the passageway is a fistula, the implantable construct including a remodelable extracellular matrix sheet material isolated as a sheet material from a collagenous-based tissue source and being effective upon implantation to stimulate the ingrowth of native tissue into the extracellular matrix sheet material so that the extracellular matrix sheet material becomes infiltrated and replaced by native tissue of the patient in said passageway for closing said passageway, the extracellular matrix sheet material being stabilized in a compressed, rolled configuration in said implantable construct with the remodelable extracellular matrix sheet material extending across the full width of the implantable construct; anddelivering the implantable construct to the passageway such that the implantable construct provides the extracellular matrix sheet material extending across the passageway so as to close the passageway with the extracellular matrix sheet material. 14. The method of claim 13, wherein the extracellular matrix material exhibits an angiogenic character. 15. The method of claim 13, wherein the extracellular matrix material includes a lyophilized extracellular matrix material. 16. The method of claim 13, wherein the extracellular matrix material comprises small intestinal submucosa. 17. The method of claim 13, wherein the implantable construct is generally cylindrical.
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