Topical composition, topical composition precursor, and methods for manufacturing and using
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-047/00
A61K-009/00
A61K-009/14
A61K-008/73
A61K-008/81
A01N-025/00
출원번호
US-0079158
(2005-03-14)
등록번호
US-8318818
(2012-11-27)
발명자
/ 주소
Roszell, James A.
Jezior, Bruce
출원인 / 주소
Skinvisible Pharmaceuticals, Inc.
대리인 / 주소
Merchant & Gould, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
72
초록▼
A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeat
A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeating pyrrolidone/alkylene groups wherein the alkylene groups contain at least 10 carbon atoms, and a hydrophilic polymer composition including repeating carboxylic groups and/or repeating hydroxyl groups. A topical composition precursor and methods for manufacturing and using a topical composition are provided by the invention.
대표청구항▼
1. A method for using a topical composition, the method comprising: (a) applying the topical composition containing an active ingredient to skin tissue so that the topical composition adheres to the skin tissue and holds the active ingredient in proximity to the skin tissue for a length of time suff
1. A method for using a topical composition, the method comprising: (a) applying the topical composition containing an active ingredient to skin tissue so that the topical composition adheres to the skin tissue and holds the active ingredient in proximity to the skin tissue for a length of time sufficient to allow delivery of the active ingredient to the skin tissue, the topical composition comprising: (i) at least 70 wt. % water;(ii) the active ingredient comprising an antimicrobial agent, an antifungal agent, an anti-inflammatory agent, or an anti-viral agent;(iii) a complex formed by melt processing a hydrophobic polymer composition and a hydrophilic polymer composition at a temperature of at least 50° C. and at a water concentration of less than 1 wt. %, wherein: (A) the hydrophobic polymer composition comprising repeating pyrrolidone/alkylene groups, wherein the alkylene groups contain at least 10 carbon atoms; and(B) the hydrophilic polymer composition selected from the group consisting of starch, cellulose, and mixtures thereof. 2. A method according to claim 1, further comprising a step of: (a) washing the skin tissue after the step of applying the topical composition. 3. A method according to claim 1, wherein the hydrophobic polymer composition comprises at least two different poly(vinylpyrrolidone/alkylene) polymers, wherein the alkylene group of each polymer contains at least 10 carbon atoms. 4. A method according to claim 1, wherein the poly(vinylpyrrolidone/alkylene) polymer comprises poly(vinylpyrrolidone/1-eicosene). 5. A method according to claim 1, wherein the poly(vinylpyrrolidone/alkylene) polymer comprises poly(vinypyrrolidone/hexadecene). 6. A method according to claim 1, wherein the complex comprises about 72 wt. % to about 98 wt. % of the hydrophobic polymer composition and about 2 wt. % to about 25 wt. % of the hydrophilic polymer composition. 7. A method according to claim 1, wherein the topical composition holds the active ingredient in proximity to the skin tissue for at least 4 hours. 8. A method according to claim 1, wherein the hydrophilic polymer composition comprises starch. 9. A method according to claim 1, wherein the hydrophilic polymer composition comprises starch having a weight average molecular weight of above 50,000 to about 20,000,000. 10. A method according to claim 1, wherein the hydrophilic polymer composition comprises partially hydrolyzed starch. 11. A method according to claim 1, wherein the hydrophilic polymer composition comprises cellulose. 12. A method according to claim 1, wherein the hydrophilic polymer composition comprises carboxymethyl cellulose. 13. A method according to claim 1, wherein the hydrophilic polymer composition comprises cellulose having a weight average molecular weight of about 50,000 to about 15,000,000. 14. A method according to claim 1, wherein the topical composition comprises 70 wt. % to about 96 wt. % water. 15. A method according to claim 1, wherein the composition further comprises about 0.5 wt. % to about 5 wt. % surfactant. 16. A method according to claim 15, wherein the surfactant is selected from the group consisting of an ethoxylated surfactant, a propoxylated surfactant, an ethoxylated-propoxylated surfactant, and a mixture thereof. 17. A method according to claim 1, further comprising a step of: (a) removing the topical composition from the skin issue as a result of natural exfoliation of the skin.
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