Microfluidic-based lab-on-a-test card for a point-of-care analyzer
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
H01L-051/10
H01L-051/30
G01N-027/00
출원번호
US-0632661
(2009-12-07)
등록번호
US-8323466
(2012-12-04)
발명자
/ 주소
Kim, Sunnie Park
Shin, Young Shik
Liu, Changgeng
Kelly, Rory
Chan, Becky
출원인 / 주소
NanoIVD, Inc.
인용정보
피인용 횟수 :
9인용 특허 :
5
초록▼
A microfluidic-based lab-on-a-test card is described. The test card is used with a point-of-care (POC) analyzer. The test card is designed to receive a sample and then, with the use of the POC analyzer, quantify or count a particular substance in the sample. The test card may be comprised of multipl
A microfluidic-based lab-on-a-test card is described. The test card is used with a point-of-care (POC) analyzer. The test card is designed to receive a sample and then, with the use of the POC analyzer, quantify or count a particular substance in the sample. The test card may be comprised of multiple layers. In one embodiment, the test card includes a primary separation chamber with a filtration surface, a trapping channel, and a particle detector. The test card may also include a nanowire sensor.
대표청구항▼
1. A device for quantifying an amount of a particular substance in a sample, the device comprising: a test chamber configured to contain the sample;a source electrode;a drain electrode, the drain electrode having a lower potential than the source electrode;a semiconducting nanowire at least partiall
1. A device for quantifying an amount of a particular substance in a sample, the device comprising: a test chamber configured to contain the sample;a source electrode;a drain electrode, the drain electrode having a lower potential than the source electrode;a semiconducting nanowire at least partially positioned within the test chamber, the semiconducting nanowire being coupled to the source electrode and the drain electrode;a detector for measuring an amount of current flowing through the nanowire; anda control electrode, at least partially positioned within the test chamber, in fluid communication with the semiconducting nanowire, wherein at least a portion of a surface of the control electrode is treated with a capture agent which selectively binds to the substance;wherein the amount of current flowing through the nanowire corresponds to a voltage applied to the control electrode, and is affected by an amount of the substance which has bound to the control electrode. 2. The device of claim 1, wherein the nanowire has a width of about 1 nm to 0.99 μm. 3. The device of claim 1, wherein the nanowire is doped to a level of approximately 1016 to 1020 holes or donor atoms/cm3. 4. The device of claim 1, wherein the control electrode has a length and width of approximately 5 μm by 5 μm to about 500 μm by 500 μm. 5. The device of claim 1, wherein the control electrode has a thickness of approximately 10 nm to 200 nm. 6. The device of claim 1, wherein the capture agent is a peptide nucleic acid (PNA), an antibody, an aptamer, or a small peptide which will bind with a biomolecule. 7. The device of claim 1, wherein the capture agent on the control electrode forms a layer having a thickness of approximately 0.1 nm to 100 nm. 8. A device for quantifying an amount of a particular substance in a sample, the device comprising: a base;a source electrode coupled to the base;a drain electrode coupled to the base, the drain electrode having a lower potential than the source electrode;a semiconducting nanowire coupled to the source electrode and the drain electrode and contacting the sample; anda control electrode coupled to the base and contacting the sample, wherein at least a portion of a surface of the control electrode is treated with a capture agent which selectively binds to the substance;wherein an amount of current flowing through the nanowire corresponds to a voltage applied to the control electrode, and is affected by an amount of the substance which has bound to the control electrode. 9. The device of claim 8, wherein the nanowire has a width of about 1 nm to 0.99 μm. 10. The device of claim 8, wherein the nanowire is doped to a level of approximately 1016 to 1020 holes or donor atoms/cm3. 11. The device of claim 8, wherein the control electrode has a length and width of approximately 5 μm by 5 μm to about 500 μm by 500 μm. 12. The device of claim 8, wherein the control electrode has a thickness of approximately 10 nm to 200 nm. 13. The device of claim 8, wherein the capture agent is a peptide nucleic acid (PNA), an antibody, an aptamer, or a small peptide which will bind with a biomolecule. 14. The device of claim 8, wherein the capture agent on the control electrode forms a layer having a thickness of approximately 0.1 nm to 100 nm.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (5)
Gu, Yuandong; Padmanabhan, Aravind, Assay implementation in a microfluidic format.
Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.