Soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61F-013/00
A61K-009/70
A61L-015/16
출원번호
US-0103967
(2005-04-12)
등록번호
US-8323675
(2012-12-04)
발명자
/ 주소
Greenawalt, Keith E.
출원인 / 주소
Genzyme Corporation
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
23인용 특허 :
361
초록▼
A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising: a three-dimensional mesh sheet comprising at least two types of yarn interlooped or intertwined to define at least two layers, wherein one of the at least two layers is substantially non-biodegr
A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising: a three-dimensional mesh sheet comprising at least two types of yarn interlooped or intertwined to define at least two layers, wherein one of the at least two layers is substantially non-biodegradable and porous to allow for tissue ingrowth and another of the at least two layers is substantially biodegradable; and an adhesion barrier in the form of a film, foam or gel, the adhesion barrier polymerized to, and entrapping therein, at least some of the yarns of the substantially biodegradable layer, the substantially biodegradable layer making a connection between the adhesion barrier and the substantially non-biodegradable layer to decrease the likelihood of delamination therefrom, the adhesion barrier being an external layer on a first side of the prosthesis and the substantially non-biodegradable layer being an external layer on the side of the prosthesis opposite the first side, the substantially biodegradable layer being positioned between the substantially non-biodegradable layer and the adhesion barrier.
대표청구항▼
1. A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising: a three-dimensional mesh sheet constructed and arranged to repair a defect of an abdominal wall or a pelvic cavity wall comprising at least two different yarns interlooped or intertwined to d
1. A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising: a three-dimensional mesh sheet constructed and arranged to repair a defect of an abdominal wall or a pelvic cavity wall comprising at least two different yarns interlooped or intertwined to define at least two layers, wherein one of the at least two layers is substantially non-biodegradable and porous to allow for tissue ingrowth and another of the at least two layers is substantially biodegradable; andan adhesion barrier in the form of a film, foam or gel, the adhesion barrier polymerized to, and entrapping therein, at least some of the yarns of the substantially biodegradable layer, the substantially biodegradable layer making a connection between the adhesion barrier and the substantially non-biodegradable layer to decrease the likelihood of delamination therefrom, the adhesion barrier being an external layer on a first side of the prosthesis and the substantially non-biodegradable layer being an external layer on the side of the prosthesis opposite the first side, the substantially biodegradable layer being positioned between the substantially non-biodegradable layer and the adhesion barrier. 2. The soft tissue prosthesis of claim 1, wherein the one of the at least two different yarns is non-biodegradable yarn. 3. The soft tissue prosthesis of claim 2, wherein the non-biodegradable yarn is selected from polypropylene, polyethylene terephthalate or a combination thereof. 4. The soft tissue prosthesis of claim 2, wherein the non-biodegradable yarn has a diameter of about 0.005 inches. 5. The soft tissue prosthesis of claim 1, wherein one of the at least two different yarns is biodegradable yarn. 6. The soft tissue prosthesis of claim 5, wherein the biodegradable yarn is selected from poly (glycolic) acid, polylactic acid, polydioxanone, polycaprolactone, calcium alginate or a combination thereof. 7. The soft tissue prosthesis of claim 5, wherein the biodegradable yarn has a diameter no greater than about 90 denier. 8. The soft tissue prosthesis of claim 1, wherein the three-dimensional mesh includes at least one non-biodegradable monofilament yarn and at least one biodegradable multifilament yarn. 9. The soft tissue prosthesis of claim 1, wherein the adhesion barrier comprises a crosslinked polymer hydrogel. 10. The soft tissue prosthesis of claim 1, wherein the adhesion barrier comprises at least one polyanionic polysaccharide modified by reaction with carbodiimide. 11. The soft tissue prosthesis of claim 1, wherein the adhesion barrier comprises a crosslinked polymer hydrogel and at least one polyanionic polysaccharide modified by reaction with carbodiimide. 12. The soft tissue prosthesis of claim 11, wherein the crosslinked polymer hydrogel comprises one or more hydrophilic blocks, one or more biodegradable blocks, and one or more crosslinking blocks. 13. The soft tissue prosthesis of claim 11, wherein the crosslinked polymer hydrogel is formed by photopolymerization of monomers comprising photopolymerizable poly(ethylene glycol)-trimethylene carbonate/lactate multi-block polymer endcapped with acrylate esters. 14. The soft tissue prosthesis of claim 11, wherein the at least one polyanionic polysaccharide modified by reaction with carbodiimide comprises carbodiimide-modified hyaluronic acid and carbodiimide-modified carboxymethylcellulose. 15. The soft tissue prosthesis of claim 1, wherein the adhesion barrier is in the form of a film or foam. 16. The soft tissue prosthesis of claim 1, wherein the adhesion barrier is in the form of a gel. 17. The soft tissue prosthesis of claim 1, wherein the surgical prosthesis has moisture content of less than about 2%. 18. The soft tissue prosthesis of claim 1, wherein the surgical prosthesis has moisture content of less than about 1.2%. 19. The soft tissue prosthesis of claim 1, wherein the adhesion barrier has a density of about 5 grams total polymer per square foot. 20. The soft tissue prosthesis of claim 1, wherein the substantially non-biodegradable layer has an external surface comprising a macroporous structure. 21. The soft tissue prosthesis of claim 20, wherein the macroporous structure has a pore size of about 100 microns or more. 22. The soft tissue prosthesis of claim 20, wherein the substantially non-biodegradable layer comprises a yarn selected from polypropylene, polyethylene terephthalate or a combination thereof. 23. The soft tissue prosthesis of claim 20, wherein the substantially biodegradable layer comprises a yarn selected from poly(glycolic) acid, polylactic acid, polydioxanone, polycaprolactone, calcium alginate or a combination thereof. 24. The soft tissue prosthesis of claim 20, wherein the barrier comprises a crosslinked polymer hydrogel and at least one polyanionic polysaccharide modified by reaction with carbodiimide. 25. The soft tissue prosthesis of claim 24, wherein the crosslinked polymer hydrogel comprises one or more hydrophilic blocks, one or more biodegradable blocks, and one or more crosslinking blocks. 26. The soft tissue prosthesis of claim 24, wherein the crosslinked polymer hydrogel is formed by polymerization of monomers comprising photopolymerizable poly(ethylene glycol)-trimethlyene carbonate/lactate multi-block polymers endcapped with acrylate esters. 27. The soft tissue prosthesis of claim 24, wherein the at least one polyanionic polysaccharide modified by reaction with carbodiimide comprises carbodiimide-modified hyaluronic acid and carbodiimide-modified carboxymethylcellulose. 28. The soft tissue prosthesis of claim 1 in which the mesh has a macroporous structure.
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