[특허]Nanoparticles having oligonucleotides attached thereto and uses therefor

[미국특허] Nanoparticles having oligonucleotides attached thereto and uses therefor 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12Q-001/68 C12Q-001/70 G01N-033/53 G01N-015/06 G05B-021/00
출원번호	US-0702002 (2007-02-02)
등록번호	US-8323888 (2012-12-04)
발명자 / 주소	Mirkin, Chad A. Letsinger, Robert L. Mucic, Robert C. Storhoff, James J. Elghanian, Robert Taton, Thomas A.
출원인 / 주소	Nanosphere, Inc.
대리인 / 주소	Pletta, Gregory T.
인용정보	피인용 횟수 : 2 인용 특허 : 127

초록 ▼

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

대표청구항 ▼

1. A method for detecting nucleic acids comprising: a) contacting a sample comprising a target nucleic acid with a substrate having a first type of oligonucleotides attached thereto, the first type of oligonucleotides comprising a sequence complementary to a first portion of the sequence of the target nucleic acid to form a target nucleic acid bound to said substrate by one or more of said first type of oligonucleotides;b) contacting the target nucleic acid bound to the substrate with a first type of nanoparticles having a second type of oligonucleotides attached thereto, the second type of oligonucleotides having a sequence complementary to a second portion of the sequence of the target nucleic acid, thereby forming a nanoparticle-oligonucleotide conjugate bound to the substrate; andc) observing detectable changes in optical properties or optoelectronic properties on the substrate resulting from the presence of the oligonucleotide conjugate; said method optionally comprising enhancing said detectable change by deposition of metal on said nanoparticle prior to said detecting; wherein said second type of oligonucleotide is bound to said nanoparticle by a disulfide containing functionality; andwherein said oligonucleotides attached to said substrate are attached to the substrate in an array. 2. The method of claim 1, where said nanoparticle is comprised of metal. 3. The method of claim 2, wherein said disulfide containing functionality is an alkanedisulfide covalently bound to the 5′ or 3′ ends of said second type of oligonucleotide. 4. The method of claim 3, wherein said metal is selected from gold, silver, copper and platinum. 5. The method of claim 1, wherein the size of the said nanoparticles is from about 5 nm to about 150 nm in mean diameter. 6. The method of claim 1, wherein the size of the said nanoparticles is from about 5 to about 50 nm in mean diameter. 7. The method of claim 1, wherein the size of the said nanoparticles is from about 10 to about 30 nm in mean diameter. 8. The method of claim 1, wherein the nucleic acid is from a biological source. 9. The method of claim 1, wherein the nucleic acid is a product of a polymerase chain reaction amplification. 10. The method of claim 1, comprising deposition of metal on said nanoparticle prior to said detecting. 11. The method of claim 10, wherein said metal is silver. 12. The method of claim 4, comprising deposition of metal on said nanoparticle prior to said detecting. 13. The method of claim 12, wherein said metal is silver. 14. The method of claim 1, wherein observing a detectable change is conducted by detecting the presence of said target nucleic acid, the quantity of said target nucleic acid, or both, with an optical scanner. 15. The method of claim 12, wherein observing a detectable change is conducted by detecting the presence of said target nucleic acid, the quantity of said target nucleic acid, or both, with an optical scanner. 16. The method of claim 1, wherein said second type of oligonucleotide comprises oligonucleotides of a single sequence bound to said nanoparticle by said disulfide containing functionality and a third oligonucleotide with a first portion and a second portion; wherein a portion of said second type of oligonucleotide has a sequence complementary to the first portion of the sequence of the third oligonucleotide; andwherein the second portion of the third oligonucleotide is said sequence complementary to a second portion of the sequence of the target nucleic acid. 17. The method of claim 12 wherein said second type of oligonucleotide comprises oligonucleotides of a single sequence bound to said nanoparticle by said disulfide containing functionality and a third oligonucleotide with a first portion and a second portion; wherein a portion of said second type of oligonucleotide has a sequence complementary to the first portion of the sequence of the third oligonucleotide with two portions; andwherein the second portion of the third oligonucleotide with two portions is said sequence complementary to a second portion of the sequence of the target nucleic acid. 18. The method of claim 13, wherein said second type of oligonucleotide comprises oligonucleotides of a single sequence bound to said nanoparticle by said disulfide containing functionality and a third oligonucleotide with a first portion and a second portion; wherein a portion of said second type of oligonucleotide has a sequence complementary to the first portion of the sequence of the third oligonucleotide with two portions; andwherein the second portion of the third oligonucleotide with two portions is said sequence complementary to a second portion of the sequence of the target nucleic acid.

이 특허에 인용된 특허 (127) 인용/피인용 타임라인 분석

Heller Michael J. (Encinitas CA) Tu Eugene (San Diego CA), Active programmable electronic devices for molecular biological analysis and diagnostics.
상세보기
Yguerabide Juan ; Yguerabide Evangelina E. ; Kohne David E. ; Jackson Jeffrey T., Analyte assay using particulate labels.
상세보기
Yguerabide, Juan; Yguerabide, Evangelina E.; Kohne, David E.; Jackson, Jeffrey T., Analyte assay using particulate labels.
상세보기
Peter Wagner ; Steffen Nock ; Dana Ault-Riche ; Christian Itin, Arrays of protein-capture agents and methods of use thereof.
상세보기
Dattagupta Nanibhushan (West Haven CT) Rae Peter M. M. (Hamden CT) Rabin Daniel U. (Branford CT) Huguenel Edward D. (Guilford CT), Assay for nucleic acid sequences in an unpurified sample.
상세보기
Lough David M.,DEX ; Koster Hubert, Bead linkers for immobilizing nucleic acids to solid supports.
상세보기
Blackburn Gary ; Creager Stephen E. ; Fraser Scott ; Irvine Bruce D. ; Meade Thomas J. ; O'Connor Stephen D. ; Terbrueggen Robert H. ; Vielmetter Jost G. ; Welch Thomas W., Binding acceleration techniques for the detection of analytes.
상세보기
Mirkin, Chad A.; Park, So-Jung; Nam, Jwa-Min, Bio-barcodes based on oligonucleotide-modified nanoparticles.
상세보기
Garimella,Viswanadham; Storhoff,James J., Bioconjugate-nanoparticle probes.
상세보기
Gref Ruxandra (Nancy FRX) Minamitake Yoshiharu (Brookline MA) Langer Robert S. (Newton MA), Biodegradable injectable nanoparticles.
상세보기
Bawendi Moungi G. ; Mikulec Frederic V. ; Sundar Vikram C., Biological applications of quantum dots.
상세보기
An Gang ; Vertri Robert W., Biomarkers and targets for diagnosis, prognosis and management of prostate disease.
상세보기
Kidwell David A. (Alexandria VA) Conyers Susan M. (Evanston IL), Biomolecules bound to catalytic inorganic particles, immunoassays using the same.
상세보기
Kidwell David A. (Alexandria VA) Conyers Susan M. (Kalamazoo MI), Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits co.
상세보기
Engelhardt Dean L. (New York NY) Rabbani Elazar (New York NY), Capture sandwich hybridization method and composition.
상세보기
Olsen Duane A. (7619 44 West No. 2 Tacoma WA 98466) Bernstein David (5814 Melville Rd. Sykesville MD 21784), Colloidal gold particle concentration immunoassay.
상세보기
Peter G. Schultz ; Xiaodong Xiang ; Isy Goldwasser, Combinatorial sythesis of organometallic materials.
상세보기
Patno,Timothy; Fisher,Mark; Maung,George Kyaw Soe; Westberg,Tom, DNA hybridization device and method.
상세보기
Laronga Victor (Mendon MA) Thorburn Stanley (Providence RI), Darkfield illuminator for a microscope slide.
상세보기
Hainfeld James F. (Shoreham NY) Furuya Frederic R. (Williston Park NY), Derivatized gold clusters and antibody-gold cluster conjugates.
상세보기
Singer Robert H. ; Politz Joan C. ; Taneja Krishan, Detection of hybridized oligonocleotide probes in living cells.
상세보기
Gordon Julian (Arlesheim CHX) Hawkes Richard (Allschwil IL CHX) Niday Evelyn (Arlington Heights IL) Towbin Harry (Allschwil CHX), Devices and kits for immunological analysis.
상세보기
Liu Yen-Ping (Santa Clara CA) Ullman Edwin F. (Atherton CA) Becker Martin J. (Palo Alto CA), Energy absorbing particle quenching in light emitting competitive protein binding assays.
상세보기
Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
상세보기
Ullman Edwin F. (Atherton CA), Fluorescent multiparameter particle analysis.
상세보기
Zuk Robert F. (Mountain View CA) Ullman Edwin F. (Atherton CA), Fluorescent scavenger particle immunoassay.
상세보기
Heller Michael J. (Poway CA) Jablonski Edward J. (San Diego CA), Fluorescent stokes shift probes for polynucleotide hybridization.
상세보기
Kurn Nurith (Palo Alto CA) Bahl Chander (San Mateo CA) Ullman Edwin F. (Atherton CA), Homogeneous assay for specific polynucleotides.
상세보기
Hansen W. Peter ; Krauledat Petra B., Homogeneous binding assay.
상세보기
Cronin Maureen T. ; Miyada Charles Garrett ; Trulson Mark ; Gingeras Thomas R. ; McGall Glenn ; Robinson Claire ; Oval Michelle, Hybridization assays on oligonucleotide arrays.
상세보기
Englehardt Dean L. (New York NY) Rabbani Elazar (New York NY), Hybridization method for the detection of genetic material.
상세보기
Nicoli David F. (448 Mills Way Goleta CA 93017) Elings Virgil B. (1155 Via Tranquila Santa Barbara CA 93110), Immunoassay using optical interference detection.
상세보기
Kausch Albert P. (Stonington CT) Narayanswami Sandya (Bar Harbor ME), Isolation of biological materials.
상세보기
Kausch Albert P. (Stonington CT) Narayanswami Sandya (Irvine CA) Manning Jerry E. (San Clemente CA) Hamkalo Barbara A. (Laguna Beach CA), Isolation of biological materials using magnetic particles.
상세보기
Brooks ; Jr. Houston G. (Somerset NJ) Chang Chi-Deu (Bridgewater NJ) Chakraborty Utpal R. (Flemington NJ) Graham ; Jr. Henry A. (Annandale NJ) Hollenbeck ; Jr. Lloyd L. (Flemington NJ) Lawler Sharon , Kit containing glutaraldehyde coated colloidal metal particles of a preselected size.
상세보기
Ullman Edwin F. (Atherton CA) Brinkley John M. (Oakland CA), Labeled liposome particle compositions and immunoassays therewith.
상세보기
Backman Keith C. (Bedford MA) Munkholm Christiane (Salem MA), Ligand assay using interference modulation.
상세보기
Shigekawa Brian L. (Chapel Hill NC) Hsieh Yung-Ao (Cary NC), Ligand gold bonding.
상세보기
Shigekawa Brian L. (Chapel Hill NC) Hsieh Yung-Ao (Cary NC), Ligand gold bonding.
상세보기
Stimpson Donald I. (Gurnee IL) Gordon Julian (Lake Bluff IL) Hoijer Joanell V. (Arlington Heights IL), Light scattering optical waveguide method for detecting specific binding events.
상세보기
Litman David J. (Cupertino CA) Harel Zvi (Haifa CA ILX) Ullman Edwin F. (Atherton CA), Macromolecular fluorescent quencher particle in specific receptor assays.
상세보기
Chang Tse-Wen (Paoli PA), Matrix of antibody-coated spots for determination of antigens.
상세보기
Leuvering Johannes H. W. (Heesch NLX), Metal sol particle immunoassay.
상세보기
Hainfeld James F. ; Furuya Frederic R. ; Powell Richard D. ; Joshi Vishwas N. ; Gutierrez Edmund, Metal-lipid molecules.
상세보기
Garimella,Viswanadham; Bernal,Yasmith, Method for attachment of silylated molecules to glass surfaces.
상세보기
Garimella,Viswanadham; Bernal,Yasmith, Method for attachment of silylated molecules to glass surfaces.
상세보기
Garimella,Viswanadham; Bernal,Yasmith, Method for attachment of silylated molecules to glass surfaces.
상세보기
Garimella,Viswanadham; Bernal,Yasmith, Method for attachment of silylated molecules to glass surfaces.
상세보기
Garimella,Viswanadham; Bernal,Yasmith, Method for attachment of silylated molecules to glass surfaces.
상세보기
Letsinger Robert Lewis (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Method for covalently linking adjacent oligonucleotides.
상세보기
Mroczkowski Susan J. (Franklin WI) Siegesmund Kenneth A. (Brookfield WI) Yorde Donald E. (Colgate WI), Method for electrical detection of a binding reaction.
상세보기
Sosnowski, Ronald G.; Butler, William F.; Tu, Eugene; Nerenberg, Michael I.; Heller, Michael J.; Edman, Carl F., Method for enhancing the hybridization efficiency of target nucleic acids using a self-addressable, self-assembling microelectronic device.
상세보기
Remacle,Jos��; Demarteau,Joseph; Zammatteo,Nathalie; Alexandre,Isabelle; Hamels,Sandrine; Houbion,Yves; De Longueville,Francoise, Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips.
상세보기
Letsinger, Robert L.; Garimella, Viswanadham, Method of detection by enhancement of silver staining.
상세보기
Patno,Tim; Hollenstein,Jennifer; Kronshage,Christian; Khoury,Christopher; Weber,Mark; Westberg,Tom; Cork,William, Method of preparing nucleic acids for detection.
상세보기
Brooks ; Jr. Houston G. (Somerset NJ) Chang Chi-Deu (Bridgewater NJ) Chakraborty Utpal R. (Flemington NJ) Graham ; Jr. Henry A. (Annandale NJ) Hollenbeck ; Jr. Lloyd L. (Flemington NJ) Lawler Sharon , Method of producing a metal sol reagent containing colloidal metal particles.
상세보기
Goldberg Martin J. ; Yelagalawadi Govinda Rao S. ; Tanimoto Eugene Yuji ; Tran Huu Minh ; Dong Helin ; Lockhart David ; Ryder Thomas B. ; Warrington Janet A. ; Beecher Jody, Methods and compositions for amplifying detectable signals in specific binding assays.
상세보기
Brown Patrick O. ; Shalon Tidhar Dari, Methods for fabricating microarrays of biological samples.
상세보기
Shalon Tidhar Dari ; Brown Patrick O., Methods for fabricating microarrays of biological samples.
상세보기
Merrill Edward W. ; Yen Diane Rintzler ; Sagar Ambuj, Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules.
상세보기
Khrapko Konstantin R. (Moscow RUX) Khorlin Alexandr A. (Moscow RUX) Ivanov Igor B. (Moskovskaya RUX) Ershov Gennady M. (Moscow RUX) Lysov Jury P. (Moscow RUX) Florentiev Vladimir L. (Moscow RUX) Mirz, Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device.
상세보기
Kavanaugh Christopher P. (Oklahoma City OK), Microscope slide having bar code indicia inscribed thereon.
상세보기
Taylor D. Lansing, Miniaturized cell array methods and apparatus for cell-based screening.
상세보기
Wohlstadter Jacob N. ; Wilbur James ; Sigal George ; Martin Mark ; Guo Liang-Hong ; Fischer Alan ; LeLand Jon, Multi-array, multi-specific electrochemiluminescence testing.
상세보기
Cork,William; Patno,Tim; Weber,Mark; Morrow,Dave; Buckingham,Wesley, Nanoparticle imaging system and method.
상세보기
Storhoff,James J.; Letsinger,Robert L.; Hagenow,Susan R., Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes.
상세보기
Ewart Thomas G.,CAX ; Bogle Gavin T.,CAX, Nanoparticles biosensor.
상세보기
Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A.; Garimella, Viswanadham; Li, Zhi, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Park, So-Jung, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin,Chad A.; Letsinger,Robert L.; Li,Zhi, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas Andrew, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas Andrew, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin,Chad A.; Letsinger,Robert L.; Mucic,Robert C.; Storhoff,James J.; Elghanian,Robert; Taton,Thomas Andrew; Garimella,Viswanadham; Li,Zhi; Park,So Jung; Lu,Gang, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin,Chad A.; Letsinger,Robert L.; Park,So Jung, Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Park,So Jung; Taton,Thomas Andrew; Mirkin,Chad A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
상세보기
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses thereof.
상세보기
Mirkin,Chad A.; Nguyen,SonBinh T., Nanoparticles with polymer shells.
상세보기
Mirkin,Chad A.; Cao,Yun Wei; Jin,Rongchao, Non-alloying core shell nanoparticles.
상세보기
Mirkin,Chad A.; Cao,Yun Wei; Jin,Rongchao, Non-alloying core shell nanoparticles.
상세보기
Mirkin,Chad A.; Cao,Yun Wei; Jin,Rongchao, Non-alloying core shell nanoparticles.
상세보기
Nelson Paul S. ; Kent Mark A., Non-nucleoside 1,3-diol reagents and their use to label or modify synthetic oligonucleotides.
상세보기
David J. Lockhart ; Mark Chee ; Kevin Gunderson ; Lai Chaoqiang ; Lisa Wodicka ; Maureen T. Cronin ; Danny Lee ; Huu M. Tran ; Hajime Matsuzaki, Nucleic acid analysis techniques.
상세보기
McGall, Glenn; Barone, Anthony D., Nucleic acid labeling compounds.
상세보기
Hollis Mark A. (Concord MA) Ehrlich Daniel J. (Lexington MA) Murphy R. Allen (Boxboro MA) Kosicki Bernard B. (Acton MA) Rathman Dennis D. (Ashland MA) Chen Chang-Lee (Sudbury MA) Mathews Richard H. (, Optical and electrical methods and apparatus for molecule detection.
상세보기
Weiss Shimon ; Bruchez ; Jr. Marcel ; Alivisatos Paul, Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such p.
상세보기
Henkens Robert W. (Durham NC) Zhao Junguo (Chapel Hill NC) O\Daly John P. (Carrboro NC), Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination.
상세보기
Schultz Sheldon ; Schultz David A. ; Smith David R. ; Mock Jack J. ; Silva Thomas J., Plasmon resonant particles, methods and apparatus.
상세보기
Natan Michael (State College PA), Self-assembled metal colloid monolayers.
상세보기
Natan Michael J., Self-assembled metal colloid monolayers and detection methods therewith.
상세보기
Alivisatos A. Paul ; Colvin Vicki L., Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers.
상세보기
Mirkin, Chad A.; Park, So-Jung; Jin, Rongchao, Silver stain removal by chemical etching and sonication.
상세보기
Hainfeld James F. (Shoreham NY) Leone Robert D. (Holtsville NY) Furuya Frederic R. (Williston Park NY) Powell Richard D. (Stamford CT), Small organometallic probes.
상세보기
Powell Richard D., Small organometallic probes.
상세보기
Demers,James Paul, Spatially addressable combinatorial chemical arrays in encoded optical disk format.
상세보기
Abbott Nicholas ; Stroeve Pieter ; Dubrovsky Timothy B. ; Hou Zhizhong, Support for high performance affinity chromatography and other uses.
상세보기
Natan Michael J. ; Keating Christine, Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches.
상세보기
Eichenlaub, Udo; Masch, Martin, System for producing multiple diagnostic test elements.
상세보기
Kossovsky Nir (Los Angeles CA) Hnatyszyn H. James (Los Angeles CA) Gelman Andrew (Los Angeles CA), Targeted transfection nanoparticles.
상세보기
Beebe Thomas P. (Salt Lake City UT) Rabke-Clemmer Carol E. (Rochester NY), Thiol labeling of DNA for attachment to gold surfaces.
상세보기
Bawendi Moungi G. ; Mikulec Frederick V. ; Lee Jin-Kyu,KRX, Water-soluble fluorescent nanocrystals.
상세보기

이 특허를 인용한 특허 (2) 인용/피인용 타임라인 분석

Kim, Young-Pil; Lee, Tae Geol, Bio-chip for secondary ion mass spectroscopy and method of fabricating the same.
상세보기
Debreczeny, Martin P.; Christman, Joseph A.; Coleman, Gerald P., Particle sensor with interferent discrimination.
상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 특허

해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[미국특허] Nanoparticles having oligonucleotides attached thereto and uses therefor 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (127) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (2) 인용/피인용 타임라인 분석

활용도 분석정보

활용도 Top5 특허

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[미국특허] Nanoparticles having oligonucleotides attached thereto and uses therefor 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (127) 인용/피인용 타임라인 분석

이 특허를 인용한 특허 (2) 인용/피인용 타임라인 분석

활용도 분석정보

활용도 Top5 특허 더보기

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 특허