IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0064497
(2011-03-29)
|
등록번호 |
US-8323954
(2012-12-04)
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발명자
/ 주소 |
- Kravitz, David C.
- Brassil, John
- Brockbank, Kelvin G. M.
- Burroughs, Andrew
- Isaacs, Dickon
- Schein, Douglas
|
출원인 / 주소 |
- Lifeline Scientific, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
99 |
초록
▼
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
대표청구항
▼
1. An organ perfusion system for perfusing an organ comprising: a first pump fluidly connected to a first perfusion circuit with a first pressure and/or flow controller disposed downstream of the first pump;a second pump fluidly connected to a second perfusion circuit with a second pressure and/or f
1. An organ perfusion system for perfusing an organ comprising: a first pump fluidly connected to a first perfusion circuit with a first pressure and/or flow controller disposed downstream of the first pump;a second pump fluidly connected to a second perfusion circuit with a second pressure and/or flow controller disposed downstream of the second pump; anda controller configured to control the first pressure and/or flow controller and the second pressure and/or flow controller,wherein the first perfusion circuit is configured to connect to a first area of the organ and the second perfusion circuit is configured to connect to a second area of the organ, andthe first pressure and/or flow controller and the second pressure and/or flow controller are controlled so that perfusion of the first area and the second area are different. 2. The organ perfusion system according to claim 1, wherein the organ is a liver and the first area is a hepatic artery of the liver and the second area is a portal vein of the liver. 3. The organ perfusion system according to claim 1, further comprising: an organ cassette for holding the organ;wherein the first perfusion circuit and the second perfusion circuit pass into and/or out of the organ cassette by way of at least one opening in the organ cassette. 4. The organ perfusion system according to claim 1, wherein at least one of the first perfusion circuit and the second perfusion circuit provide oxygenation to a perfusate. 5. The organ perfusion system according to claim 1, wherein the first perfusion circuit provides oxygenation to a first perfusate and the second perfusion circuit provides oxygenation to a second perfusate. 6. The organ perfusion system according to claim 1, wherein the organ is perfused at normothermic temperature. 7. The organ perfusion system according to claim 1, wherein the first perfusion circuit and the second perfusion circuit are independent from one another. 8. The organ perfusion system according to claim 1, wherein the first perfusion circuit and the second perfusion circuit are configured to have different flow rates. 9. The organ perfusion system according to claim 1, wherein the first perfusion circuit provides pulsatile flow and the second perfusion circuit provides continuous flow. 10. The organ perfusion system according to claim 1, wherein: the first perfusion circuit further comprises a first pressure sensor and a first flow sensor, andthe second perfusion circuit further comprises a second pressure sensor and a second flow sensor. 11. The organ perfusion system according to claim 1, wherein the first perfusion circuit comprises a first branch that is configured to wash the organ, the first branch being upstream of the first pressure and/or flow controller. 12. The organ perfusion system according to claim 11, wherein the first branch comprises a first valve. 13. The organ perfusion system according to claim 11, wherein the second perfusion circuit comprises a second branch that is configured to wash the organ, the second branch being upstream of the second pressure and/or flow controller. 14. The organ perfusion system according to claim 13, wherein the second branch comprises a first valve. 15. The organ perfusion system according to claim 1, wherein the first perfusion circuit includes a first oxygenator between the first pump and the organ and the second perfusion circuit includes a second oxygenator between the second pump and the organ. 16. The organ perfusion system according to claim 1, wherein the first pressure and/or flow controller is a flow control valve. 17. The organ perfusion system according to claim 1, wherein the second pressure and/or flow controller is a flow control valve. 18. A method for perfusing an organ comprising: fluidly connecting a first pump and a first perfusion circuit with a first pressure and/or flow controller downstream of the first pump to a first area of the organ;fluidly connecting a second pump and a second perfusion circuit with a second pressure and/or flow controller downstream of the second pump to a second area of the organ;perfusing the first area of the organ with the first pump and the first perfusion circuit;perfusing the second area of the organ with the second pump and the second perfusion circuit, andcontrolling perfusion of the first area of the organ and perfusion of the second area of the organ to be different. 19. The method for perfusing an organ according to claim 18, further comprising: oxygenating a perfusate in at least one of the first perfusion circuit and the second perfusion circuit. 20. The method for perfusing an organ according to claim 18, oxygenating a first perfusate in the first perfusion circuit and oxygenating a second perfusate in the second perfusion circuit. 21. The method for perfusing an organ according to claim 18, further comprising: monitoring the first perfusion circuit with a first pressure sensor and a first flow sensor, andmonitoring the second perfusion circuit with a second pressure sensor and a second flow sensor. 22. The method for perfusing an organ according to claim 21, further comprising: controlling the perfusing the first area based on the monitoring of the first perfusion circuit, andcontrolling the perfusing the second area based on the monitoring of the second perfusion circuit. 23. An organ perfusion system for perfusing an organ comprising: a first means for pumping that is fluidly connected to a first circuit means for perfusing and a first pressure and/or flow control means downstream of the first means for pumping;a second means for pumping that is fluidly connected to a second circuit means for perfusing and a second pressure and/or flow control means downstream of the second means for pumping; anda control means for controlling the first pressure and/or flow control means and the second pressure and/or flow control means,wherein the first circuit means is configured to connect to a first area of the organ and the second circuit means is configured to connect to a second area of the organ, andthe first pressure and/or flow control means and the second pressure and/or flow control means are controlled so that perfusion of the first area and the second area are different.
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