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A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavit

A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavity.

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1. A cover for a microscope slide, said cover comprising: a planar body with a cavityed face and an opposed face, two side walls flanking the cavityed face, two legs that extend out from the side walls on the cavityed face and that are not in contact with the opposing face, and a locater attached to

1. A cover for a microscope slide, said cover comprising: a planar body with a cavityed face and an opposed face, two side walls flanking the cavityed face, two legs that extend out from the side walls on the cavityed face and that are not in contact with the opposing face, and a locater attached to the planar body;wherein the planar body is configured to slideably engage the microscope slide so that the cavityed face is parallel to the planar surface of the microscope slide and so that the side walls support the cover on the microscope slide;wherein the locater can be used to slideably move the cavityed face parallel to a planar surface of the microscope slide;wherein the planar body has a front end and a distal end and is shaped so that the front end extends upwardly and away from the cavityed face toward the opposed face to form a projection;wherein the opposed face is sized so as to cover less than the whole length of the planar surface of the microscope slide; andwherein when the cover is engaged with the microscope slide, (1) a cavity is defined by the cavityed face, the two side walls and the portion of the microscope slide engaged with the side walls, and (2) a reservoir is defined by the projection, the legs, and the portion of the microscope slide not engaged by the side walls. 2. The cover of claim 1, wherein when formed, the cavity's volume is between 20 and 300 microliters. 3. The cover of claim 1, wherein the projection is defined by a first section, angled at least at substantially 60° relative to the cavity, and a second section, positioned between the cavity and the first section, and orientated at a reduced angle relative to the cavity, as compared to the first section. 4. The cover of claim 3, wherein the second section is angled at least at substantially 15°. 5. The cover of claim 1, wherein the cover is made from a polymer material. 6. The cover of claim 5, wherein the cavity includes a coating of reduced surface roughness than the polymer material. 7. The cover of claim 1, wherein the cavity includes a coating with reduced porosity. 8. The cover of claim 1, wherein the cavity has one or more coatings. 9. The cover of claim 8, wherein a first coating is a material having similar properties to the material of the slide. 10. The cover of claim 9, wherein the first coating is silicon dioxide. 11. The cover of claim 9, wherein a second coating is placed intermediate a first coating to provide improved contact properties between the cover and first coating. 12. The cover of claim 1, wherein the cavity is substantially planar. 13. The cover of claim 1, wherein the reservoir is further defined between the projection, and legs attached to the side walls and which extend beyond the frontal end. 14. The cover of claim 1, wherein the cavity extends to the distal wall of the cover adjacent the locator. 15. The cover of claim 1, wherein when the cover is engaged with the microscope slide, the reservoir is sized to 150% of the volume of the cavity. 16. The cover of claim 1, wherein the cavity extends the full width of a sample holding region of the microscope slide. 17. The cover of claim 1, wherein a protrusion extends from the projection, to assist in wicking fluid into the reservoir. 18. The cover of claim 1, further comprising wing structures attached to the planar body configured to allow the cover to be engaged and pivoted relative to the microscope slide so as to open the cavity and allow the slide to be cleared of fluid. 19. A combination of a microscope slide, and a cover as claimed in claim 1, wherein the cavity of the cover is arranged to face the microscope slide so as to form a reaction chamber. 20. The combination of claim 19, wherein the reservoir is sized to 150% of the volume of the cavity. 21. The combination of claim 19, wherein the cavity's volume is between 20 and 300 microliters. 22. A method of treatment of a sample on a sample holding region of a microscope slide, comprising locating the cover of claim 1, over the slide, so that the cavity of the cover faces the slide to form a reaction chamber over the sample holding region, and depositing fluid into the fluid reservoir to allow the fluid to be drawn into the reaction chamber. 23. A method as claimed in claim 22, further comprising sliding the cover relative to the microscope slide to vary a degree of overlap between the cover and the sample holding region, which results in a corresponding variation in the reaction chamber volume. 24. A method as claimed in claim 22, wherein the cover further comprises wing structures attached to the planar body configured to allow the cover to be engaged and pivoted relative to the microscope slide and further comprising sliding the cover relative to the microscope slide until the wing structures are engaged and lifted relative to the microscope slide to pivot the cover into an open condition, thereby allowing fluid to drain from the reaction chamber. 25. A cover for a microscope slide, said cover comprising: a body defining a cavity when positioned over the microscope slide to form a reaction chamber, said body including a bottom surface and longitudinally extending side walls which support the body such that a space of a first height is provided between a top surface of the slide and the bottom surface of the body, said space defining the cavity;a projection extending from a first end of the body and laterally across a width of the body and being positioned above the bottom surface of the body to define a fluid reservoir with the top surface of the microscope slide when positioned over the slide, said fluid reservoir having a second height greater than the first height where the second height is corresponds to a distance from the top surface of the slide to a bottom surface of the projection, the fluid reservoir being separate from and in fluid communication with the cavity;an outlet at a second end of the cover distal from the first end; anda locator for controlling and locating the cover.