초록 ▼

Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 f

Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof; and optionally an emollient ester such as diesters of bibasic acids and triesters of citric acid. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance.

대표청구항 ▼

1. An antimicrobial composition comprising: a) a C2-C5 lower alcohol present in an amount of at least 35 wt-%;b) a fatty component containing one or more free hydroxyl groups selected from the group consisting of C12-C21 fatty alcohols, C12-C21 fatty ethers, C12-C21 fatty amides, and combinations of

1. An antimicrobial composition comprising: a) a C2-C5 lower alcohol present in an amount of at least 35 wt-%;b) a fatty component containing one or more free hydroxyl groups selected from the group consisting of C12-C21 fatty alcohols, C12-C21 fatty ethers, C12-C21 fatty amides, and combinations of all of the foregoing; wherein the fatty component is present in the composition in an amount of at least 2 wt-%; andc) a cationic antimicrobial agent present in an amount of at least 0.5 wt-% based upon the total weight of the antimicrobial composition; andd) water, wherein the lower alcohol to water weight ratio is between 40:60 to 95:5;wherein the fatty component and the cationic antimicrobial are dissolved in the antimicrobial composition, and the antimicrobial composition is a solution; wherein the antimicrobial composition is free of surfactants with an HLB greater than 6;wherein if any component of the composition is ethoxylated, no more than two moles of ethylene oxide are included; andwherein the antimicrobial composition is essentially free of hydrophilic polymers. 2. An antimicrobial composition comprising: a) a C2-C5 lower alcohol present in an amount of at least 35 wt-%;b) a fatty component containing one or more free hydroxyl groups selected from the group consisting of C12-C21 fatty alcohols, C12-C21 fatty esters, C12-C21 fatty ethers, C12-C21 fatty amides, and combinations of all of the foregoing;c) a cationic antimicrobial agent present in an amount of at least 0.5 wt-% based upon the total weight of the antimicrobial composition;(d) an emollient ester selected from the group consisting of diesters of bibasic acids, triesters of citric acid, diesters of diols, triesters of triols, and combinations thereof; wherein the emollient ester is present in an amount greater than 1 wt-% based on the total weight of the composition; ande) water, wherein the lower alcohol to water weight ratio is between 40:60 to 95:5;wherein the fatty component, the emollient ester, and the cationic antimicrobial are dissolved in the antimicrobial composition, and the antimicrobial composition is a solution. 3. The antimicrobial composition of claim 1, wherein the ratio of the fatty component to the cationic antimicrobial agent is at least 0.5:1. 4. The antimicrobial composition of claim 2, wherein the ratio of the combination of the fatty component and the emollient ester to the cationic antimicrobial agent is at least 1:1. 5. The antimicrobial composition of claim 2, wherein the fatty component is present in the composition in an amount of at least 2 wt-% based on the total weight of the antimicrobial composition. 6. The antimicrobial composition of claim 2, wherein the emollient ester is present in the composition in an amount of at least 2 wt-% based on the total weight of the antimicrobial composition. 7. The composition of claim 1, further comprising an emollient ester selected from the group consisting of diesters of bibasic acids, triesters of citric acid, diesters of diols, triesters of triols, and combinations thereof. 8. The antimicrobial composition of claim 1, wherein the C12-C21 fatty alcohol is selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isocetyl alcohol, octyl dodecanol, 2-hexyl decanol, 2-hexyl dodecanol, and combinations thereof. 9. The antimicrobial composition of claim 2, wherein the emollient ester has a solubility in water of less than 2 wt-%. 10. The antimicrobial composition of claim 9, wherein the emollient ester is a liquid at room temperature. 11. The antimicrobial composition of claim 2, wherein at least one of the fatty component and the emollient ester has a melt temperature greater than 23° C. 12. The antimicrobial composition of claim 1, wherein the cationic antimicrobial agent is selected from the group consisting of chlorhexidine, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dimethosulfate, and chlorhexidine dilactate salts, polyhexamethylenebiguanide, benzalkonium halides, and combinations thereof. 13. The antimicrobial composition of claim 2, wherein the emollient ester is selected from the group consisting of dibutyl adipate, diisopropyl adipate, diisobutyl adipate, dihexyl adipate, diisopropyl sebacate, dibutyl sebacate, tributyl citrate, diesters of butanediol and hexanediol, propylene glycol dicaprylate, and combinations thereof. 14. The antimicrobial composition of claim 2 wherein the ratio of the fatty component to the cationic antimicrobial agent is at least 0.5:1. 15. The antimicrobial composition of claim 2, wherein the C12-C21 fatty alcohol is selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isocetyl alcohol, octyl dodecanol, 2-hexyl decanol, 2-hexyl dodecanol, and combinations thereof. 16. The antimicrobial composition of claim 7, wherein the emollient ester has a solubility in water of less than 2 wt-%. 17. The antimicrobial composition of claim 2, wherein the cationic antimicrobial agent is selected from the group consisting of chlorhexidine, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dimethosulfate, and chlorhexidine dilactate salts, polyhexamethylenebiguanide, benzalkonium halides, and combinations thereof. 18. The antimicrobial composition of claim 7, wherein the emollient ester is selected from the group consisting of dibutyl adipate, diisopropyl adipate, diisobutyl adipate, dihexyl adipate, diisopropyl sebacate, dibutyl sebacate, tributyl citrate, diesters of butanediol and hexanediol, propylene glycol dicaprylate, and combinations thereof.