IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0019273
(2011-02-01)
|
등록번호 |
US-8374674
(2013-02-12)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
41 인용 특허 :
269 |
초록
▼
A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside
A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside the patient so that the energy can interact with the agent to treat a nerve.
대표청구항
▼
1. A treatment system, comprising: a therapeutic ultrasonic energy source comprising a transducer; anda processor coupled to the transducer, wherein the processor is configured to control the transducer using information regarding a blood vessel from an imaging device to apply ultrasonic energy to a
1. A treatment system, comprising: a therapeutic ultrasonic energy source comprising a transducer; anda processor coupled to the transducer, wherein the processor is configured to control the transducer using information regarding a blood vessel from an imaging device to apply ultrasonic energy to a nerve region next to the blood vessel;wherein the processor is configured to operate the transducer to apply the ultrasonic energy to treatment areas that are arranged approximately in a spherical or ellipsoidal configuration around a reference position associated with the blood vessel, to thereby treat nerve tissue in the nerve region on at least two sides of the blood vessel so that the nerve tissue on the at least two sides of the blood vessel receives more therapeutic effect than the blood vessel. 2. The system of claim 1, further comprising a module to track motion of the blood vessel. 3. The system of claim 1, wherein the nerve tissue extends around the blood vessel, and wherein the processor is configured to cause the transducer to create a zone of heat surrounding the blood vessel to create an annular region around the blood vessel to modulate the nerve tissue surrounding the blood vessel. 4. The system of claim 1, wherein the transducer is configured to apply power to the nerve region, the power having a value that is anywhere from 100 W/cm2 to 2500 W/cm2. 5. The system of claim 1, further comprising a patient interface configured to position the therapeutic ultrasonic energy source so that regions of bone are avoided by the ultrasonic energy from the transducer. 6. The system of claim 1, wherein the nerve region is an autonomic nerve region, and the transducer is configured to apply the ultrasonic energy at an energy level to create a reduction in a norepinephrine output of the autonomic nerve region. 7. The system of claim 1, further comprising a motion tracking module to track a movement of the blood vessel. 8. The system of claim 7, wherein the motion tracking module is configured to track speckles. 9. The system of claim 7, wherein the motion tracking module is configured to determine a three dimensional coordinate of the blood vessel. 10. The system of claim 7, wherein the motion tracking module is configured to track a doppler ultrasound signal from the blood vessel. 11. The system of claim 1, wherein the processor is configured to operate the transducer so that the transducer applies the ultrasonic energy simultaneously to the nerve tissue on the at least two sides of the blood vessel. 12. The system of claim 1, further comprising the imaging device, wherein the imaging device is configured to visualize the blood vessel in the nerve region with ultrasound. 13. The system of claim 1, further comprising the imaging device, wherein the imaging device is configured to detect a presence of the blood vessel by a Doppler signal. 14. The system of claim 1, further comprising the imaging device, wherein the imaging device comprises an MRI machine. 15. The system of claim 1, further comprising the imaging device, wherein the imaging device is configured to detect a catheter. 16. The system of claim 15, wherein the imaging device is configured to detect the catheter when the catheter is in a renal artery, a renal vein, or a vena cava. 17. The system of claim 15, wherein the imaging device is placed outside a patient and is configured to receive ultrasound pulses emitted from inside the patient to determine a three dimensional coordinate of the catheter. 18. A treatment system, comprising: a therapeutic ultrasonic energy source comprising a transducer for placement on a patient's skin, and for delivery of focused ultrasound energy through the skin of the patient;a diagnostic imaging device configured to detect flow in a blood vessel; anda processor coupled to the transducer, wherein the processor is configured to control the transducer using information regarding the blood vessel from the diagnostic imaging device to deliver the focused ultrasound energy to treatment areas that are arranged approximately in a spherical or ellipsoidal configuration, to heat a nerve region that is next to the blood vessel. 19. The system of claim 18, wherein the processor is configured to operate the transducer to heat tissue in the nerve region on at least two sides of the blood vessel by applying the focused ultrasound energy through the blood vessel from the transducer. 20. The system of claim 18, wherein the diagnostic imaging device comprises an ultrasound device. 21. The system of claim 18, wherein the diagnostic imaging device comprises a MRI device. 22. The system of claim 18, wherein the diagnostic imaging device is configured to detect a fiducial inside the patient. 23. The system of claim 22, wherein the fiducial comprises a catheter. 24. The system of claim 18, wherein the processor is configured to operate the transducer to create a heat zone having an annular configuration. 25. The system of claim 18, wherein the processor is configured to determine a position of the blood vessel, and to control the transducer to deliver the focused ultrasound energy to one of the treatment areas that is about ten millimeters away from the position of the blood vessel. 26. The system of claim 18, wherein the processor is configured to control the transducer to deliver the focused ultrasound energy to the treatment areas surrounding a lumen of the blood vessel. 27. The system of claim 18, wherein the processor is configured to execute a treatment plan to control the transducer to deliver the ultrasound energy through a path from an external position posterior to the patient, the path being prescribed by the treatment plan to intersect a kidney while avoiding bone and bowel tissue. 28. The system of claim 18, further comprising a sensor for detecting temperature of the nerve region during the heating of the tissue. 29. The system of claim 18, wherein the processor is configured to control the transducer by targeting the blood vessel. 30. A treatment system, comprising: a therapeutic ultrasonic energy source comprising a transducer; anda processor coupled to the transducer, wherein the processor is configured to control the transducer using information from an imaging device, and wherein the processor is configured to operate the transducer to deliver the ultrasonic energy to treatment areas that are arranged approximately in a spherical or ellipsoidal configuration around a reference position associated with a blood vessel to thereby treat a nerve adjacent the blood vessel; anda motion tracking system configured to track the blood vessel;wherein the processor is further configured to adjust the delivery of the ultrasonic energy to the nerve using the tracked blood vessel. 31. The system of claim 30, wherein the processor is configured to operate the transducer to create a heat zone having an annular configuration. 32. The system of claim 30, wherein the processor is configured to determine a position of the blood vessel, and to control the transducer to deliver the ultrasonic energy to one of the treatment areas that is about ten millimeters away from the position of the blood vessel. 33. The system of claim 30, wherein the processor is further configured to execute a treatment plan to control the transducer to deliver the ultrasonic energy through a path from an external position posterior to a patient, the path being prescribed by the treatment plan to intersect a kidney while avoiding bone and bowel tissue. 34. The system of claim 30, wherein the motion tracking system is configured to detect a position of an indwelling vascular catheter. 35. The system of claim 30, further comprising the imaging device, wherein the imaging device is configured to detect an indwelling catheter.
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