IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0183000
(2005-07-14)
|
등록번호 |
US-8376984
(2013-02-19)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
7 인용 특허 :
6 |
초록
▼
An apparatus for delivering a bioactive material to a subterranean layer of a skin architecture is provided that includes a head including one or more needles that are operable to penetrate a stratum corneum of a skin. A bioactive material is disposed on one or more of the needles, whereby movement
An apparatus for delivering a bioactive material to a subterranean layer of a skin architecture is provided that includes a head including one or more needles that are operable to penetrate a stratum corneum of a skin. A bioactive material is disposed on one or more of the needles, whereby movement of the head operates to pick up the bioactive material and to deliver a portion of the bioactive material to a selected location, the selected location being a dermis, or an epidermis, or both the dermis and the epidermis. In more particular embodiments, the bioactive material is a macromolecule substance that is part of a group of substances, the group consisting of a protein, a vitamin, a gene, a growth agent, a drug, and a peptide. The needles create an injury that triggers collagen production from one or more fibroblasts in the skin.
대표청구항
▼
1. An apparatus for delivering a bioactive material to a subterranean layer of a skin architecture, comprising: a head including one or more needles that are operable to penetrate a stratum corneum of a skin, wherein a bioactive material is disposed on one or more of the needles, whereby movement of
1. An apparatus for delivering a bioactive material to a subterranean layer of a skin architecture, comprising: a head including one or more needles that are operable to penetrate a stratum corneum of a skin, wherein a bioactive material is disposed on one or more of the needles, whereby movement of the head operates to pick up the bioactive material and to deliver a portion of the bioactive material to a selected location, the selected location being a dermis, or an epidermis, or both the dermis and the epidermis, wherein rolling the apparatus over an area of the skin fifteen times will result in at least 200 pricks/centimeter squared, and wherein the bioactive material is formulated to cause collagen proliferation. 2. The apparatus of claim 1, wherein the bioactive material is a macromolecule substance that is part of a group of substances, the group consisting of: a) a protein;b) a vitamin;c) a gene;d) a growth agent;e) a peptide; andf) a drug. 3. The apparatus of claim 1, wherein the needles create an injury that triggers collagen production from one or more fibroblasts in the skin. 4. The apparatus of claim 1, wherein the needles are operable to create holes in the stratum corneum, the holes being in a range of 0.02 mm to 0.18 mm in diameter. 5. The apparatus of claim 1, wherein the needles are positioned at an angle having a range between 12° and 25° when compared to the head, which is used as a reference point for angle determination. 6. The apparatus of claim 1, wherein the needles are provided in an arrangement that includes between 6 and 14 needle rows. 7. The apparatus of claim 1, wherein the needles are of a length of about 0.15 mm to 2.5 mm. 8. The apparatus of claim 1 further comprising: a fork element coupled to the head and operable to provide a holding mechanism for an end user of the apparatus. 9. The apparatus of claim 1, wherein the head has a width between 5 mm and 30 mm. 10. The apparatus of claim 1, wherein the bioactive material is delivered at the stratum corneum of the skin, to the bottom of the epidermis, to the top of the dermis, or to the middle of the dermis, and wherein a depth of delivery of the bioactive material is determined by a length, an angle, and a needle separation associated with the needles, and wherein the separation of the needles is in a range of 1.5-2.0 mm. 11. The apparatus of claim 1, wherein the head is a selected one of a roller head and a flat head. 12. The apparatus of claim 1, wherein the delivery of the bioactive material comprises a physical transport of the bioactive material. 13. A method, comprising: providing a head with one or more needles that are operable to penetrate a stratum corneum of a skin; andmanufacturing the head to allow for positioning of a bioactive material on one or more of the needles, whereby movement of the head operates to pick up the bioactive material and to deliver a portion of the bioactive material to a selected location, the selected location being a dermis, or an epidermis, or both the dermis and the epidermis, wherein rolling the head over an area of the skin fifteen times will result in at least 200 pricks/centimeter squared, and wherein the bioactive material is formulated to cause collagen proliferation. 14. The method of claim 13, wherein the bioactive material is a macromolecule substance that is part of a group of substances, the group consisting of: a) a protein;b) a vitamin;c) a gene;d) a growth agent;e) a peptide; andf) a drug. 15. The method of claim 13, wherein the needles create an injury that triggers collagen production from one or more fibroblasts in the skin. 16. The method of claim 13, further comprising: positioning the needles on the head in order to create holes in the stratum corneum, the holes being in a range of 0.02 mm to 0.18 mm in diameter. 17. The method of claim 13, further comprising: positioning the needles at an angle having a range between 12° and 25° when compared to the head, which is used as a reference point for angle determination. 18. The method of claim 13, further comprising: positioning the needles in an arrangement that includes between 6 and 14 needle rows. 19. The method of claim 13, wherein the head is designed to be used in a selected application, the application being part of a group of applications, the group consisting of: a) percutaneous collagen induction therapy;b) vaccine delivery;c) gene therapy;d) scarring applications; ande) drug applications. 20. The method of claim 13, further comprising: providing the head with a fork element coupled to the head and operable to provide a holding mechanism for an end user of the apparatus. 21. The method of claim 13, further comprising: packaging the head along with the bioactive material such that the head and the bioactive material can cooperate and be used together. 22. The method of claim 13, further comprising: providing a stand that may be used to support or to stabilize the device. 23. The method of claim 13, wherein the needles are of a length of about 0.15 mm to 2.5 mm and the head has a width between 5 mm and 30 mm. 24. The method of claim 13, wherein a separation of the needles is in a range of 1.5-2.0 mm. 25. The method of claim 13, wherein a depth of delivery of the bioactive material is determined by a length, an angle, and a needle separation associated with the needles.
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