[특허]Drug solution filling plastic ampoule and process for producing the same

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61B-019/00 A61M-005/28 A61M-005/00 B65D-053/00 B65D-053/06 B65D-001/09
출원번호	US-0554094 (2004-04-19)
등록번호	US-8377029 (2013-02-19)
우선권정보	JP-2003-118901 (2003-04-23); JP-2003-364971 (2003-10-24)
국제출원번호	PCT/JP2004/005547 (2004-04-19)
§371/§102 date	20051021 (20051021)
국제공개번호	WO2004/093775 (2004-11-04)
발명자 / 주소	Nagao, Katsuyoshi Okamoto, Hideshi Izumi, Masamitsu Kawakami, Keiichi Inoue, Fujio
출원인 / 주소	Otsuka Pharmaceutical Factory, Inc.
인용정보	피인용 횟수 : 40 인용 특허 : 18

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A drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule includes a container body

A drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule includes a container body, a fusion-bonded portion which seals a mouth of the container body, and a wrench-off holder tab connected to the fusion-bonded portion. The ampoule is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability.

대표청구항 ▼

1. A drug solution filling plastic ampoule comprising: a flexible container body having a mouth and containing a drug solution;a fusion-bonded portion which seals the mouth of the container body;and a holder tab connected to the fusion-bonded portion for wrenching off the fusion-bonded portion to op

1. A drug solution filling plastic ampoule comprising: a flexible container body having a mouth and containing a drug solution;a fusion-bonded portion which seals the mouth of the container body;and a holder tab connected to the fusion-bonded portion for wrenching off the fusion-bonded portion to open the mouth of the container body, whereinthe flexible container body, the fusion-bonded portion and the holder tab are integrally molded from a tubular parison having three or more layers including an innermost layer composed of a polyolefin, an intermediate layer composed of blends of 20 to 50 wt % of polyolefin and 50 to 80 wt % of polycycloolefin to provide the container body with a steam permeation preventing capability and a drug permeation preventing capability and an outermost layer composed of a polyolefin, anda thickness of the intermediate layer is from 11.8 to 35.3% of a total thickness of the three or more layers. 2. A drug solution filling plastic ampoule as set forth in claim 1, wherein the container body includes at least one layer other than the innermost layer and the intermediate layer that is composed of a material containing at least one additive selected from the group consisting of a colorant, a UV absorbing agent and an oxygen absorbing agent, said intermediate layer being provided inward of the additive-containing layer. 3. A drug solution filling plastic ampoule as set forth in claim 1, which is an ampoule sequence including a plurality of ampoules connected to one another via severable thin wall portions. 4. A drug solution filling plastic ampoule as set forth in claim 1, wherein the container body of the plastic ampoule has a volume of 0.5 to 20 mL. 5. A production method for a drug solution filling plastic ampoule comprising the steps of: molding a container body having a mouth by holding a tubular parison between lower split mold pieces and forming a void in the parison, the parison having three or more layers including an innermost layer composed of a polyolefin, an intermediate layer composed of blends of 20 to 50 wt % of polyolefin and 50 to 80 wt % of polycycloolefin to provide the container body with a steam permeation preventing capability and a drug permeation preventing capability and an outermost layer composed of a polyolefin,a thickness of the intermediate layer being from 11.8 to 35.3% of a total thickness of the three or more layers;filling a drug solution in the container body; andholding the mouth of the container body between upper split mold pieces to form a fusion-bonded portion which seals the mouth of the container body and a holder tab which is connected to the fusion-bonded portion to be used for wrenching off the fusion-bonded portion to open the mouth of the container body. 6. A drug solution filling plastic ampoule production method as set forth in claim 5, wherein the parison includes at least one layer other than the innermost layer and the intermediate layer that is composed of a material containing at least one additive selected from the group consisting of a colorant, a UV absorbing agent and an oxygen absorbing agent, said intermediate layer being provided inward of the additive-containing layer.

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