A silver composition comprising silver sulfate and a method of coating the composition on a substrate is disclosed.
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1. A method of making an antimicrobial wound dressing, the method comprising: preparing a composition comprising silver sulfate and water; wherein any stabilizing agent is present in an amount less than 50 ppm based on the total weight of the silver sulfate composition;coating the silver sulfate com
1. A method of making an antimicrobial wound dressing, the method comprising: preparing a composition comprising silver sulfate and water; wherein any stabilizing agent is present in an amount less than 50 ppm based on the total weight of the silver sulfate composition;coating the silver sulfate composition on a cellulosic substrate;drying the coated substrate at a temperature of 125° C. to 190° C., such that the coated substrate darkens in proportion to the temperature, turning to a yellow color, a brown color, or a dark brown color;wherein after drying, the composition includes less than 20 wt % silver metal, based on the total weight of silver components in the composition; andmaintaining the dried silver sulfate coated substrate at a relative humidity of no more than 50%;wherein the dry antimicrobial wound dressing is color stable. 2. The method of claim 1, wherein the cellulosic substrate comprises cotton. 3. The method of claim 1, wherein the silver sulfate composition further comprises silver compounds other than silver sulfate. 4. The method of claim 3, wherein the silver compounds are selected from the group consisting of silver oxide, silver nitrate, silver acetate, silver citrate, silver chloride, silver lactate, silver phosphate, silver stearate, silver thiocyanate, silver carbonate, silver saccharinate, silver anthranilate and combinations thereof. 5. The method of claim 3, wherein the silver sulfate is present in an amount of at least 60 wt % of the composition based on the total weight of the silver components of the composition. 6. The method of claim 1, wherein the pH of the silver sulfate coating composition is at least 4. 7. The method of claim 6, wherein the pH of the coating composition is no greater than 9. 8. The method of claim 1, wherein the silver sulfate composition is free of any acid. 9. The method of claim 1, wherein the substrate is a nonwoven gauze, a woven gauze, a film, or a hydrocolloid. 10. The method of claim 1, wherein the silver sulfate composition further comprises methanol, ethanol, isopropanol, acetone, or an organic solvent that is miscible with water. 11. A method of making an antimicrobial wound dressing, the method comprising: preparing a composition comprising silver sulfate and water; wherein any stabilizing agent is present in an amount less than 50 ppm based on the total weight of the silver sulfate compositioncoating the silver sulfate composition on a cellulosic substrate;drying the coated substrate at a temperature of 125° C. to 190° C. such that the coated substrate changes color to a color is selected from the group consisting of yellow, gold, tan, and brown; wherein the dried composition includes less than 20 wt % silver metal, based on the total weight of silver components in the composition;wherein the dry antimicrobial wound dressing is color stable. 12. The method of claim 11, wherein the antimicrobial wound dressing is maintained in an environment of no more than 50% relative humidity at room temperature. 13. The method of claim 12, wherein the antimicrobial wound dressing is maintained in an environment of no more than 20% relative humidity at room temperature. 14. The method of claim 11, wherein the silver sulfate composition further comprises silver compounds other than silver sulfate. 15. The method of claim 14, wherein the silver compounds are selected from the group consisting of silver oxide, silver nitrate, silver acetate, silver citrate, silver chloride, silver lactate, silver phosphate, silver stearate, silver thiocyanate, silver carbonate, silver saccharinate, silver anthranilate and combinations thereof. 16. The method of claim 14, wherein the silver compounds comprise less than 20 wt % of the composition, based on the total weight of the silver components of the composition. 17. The method of claim 11, wherein the silver sulfate is present in an amount of at least 60 wt % of the composition, based on the total weight of the silver components of the composition. 18. The method of claim 17, wherein the silver sulfate is present in an amount of at least 90 wt % of the composition, based on the total weight of the silver components of the composition. 19. The method of claim 11, wherein the pH of the coating composition is at least 4. 20. The method of claim 11, wherein the pH of the coating composition is no greater than 9. 21. The method of claim 11, wherein the silver sulfate composition is free of any acid. 22. The method of claim 11, wherein the drying is carried out at a temperature of less than 170° C. 23. The method of claim 11, wherein the drying is carried out at a temperature of at least 140° C. 24. The method of claim 11, wherein the substrate is a nonwoven gauze, a woven gauze, a film, or a hydrocolloid. 25. The method of claim 24, wherein the cellulosic substrate comprises cotton. 26. The method of claim 1, wherein the drying is carried out at a temperature of less than 190° C. 27. The method of claim 26, wherein the drying is carried out at a temperature of less than 170° C. 28. The method of claim 1, wherein the drying is carried out at a temperature of 140° C. to 170° C.
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