IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0564788
(2006-11-29)
|
등록번호 |
US-8403996
(2013-03-26)
|
발명자
/ 주소 |
- Brekke, John H.
- Bradica, Gino
- Goldman, Scott M.
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
49 |
초록
▼
An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environm
An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.
대표청구항
▼
1. A porous, multi-component device for repair of articular cartilage defects, comprising: a. a first region comprising a first component in the form of a microstructure presenting a porous intercommunicating network for cellular attachment, and a second component in the form of a fibrous macrostruc
1. A porous, multi-component device for repair of articular cartilage defects, comprising: a. a first region comprising a first component in the form of a microstructure presenting a porous intercommunicating network for cellular attachment, and a second component in the form of a fibrous macrostructure supporting the first component and;b. a second region comprising a third component of porous polymer attached to the first and second components. 2. The device of claim 1, wherein said first component comprises acid soluble collagen. 3. The device of claim 1, wherein said second component comprises insoluble collagen. 4. The device of claim 1, wherein said polymer of said third component comprises polymerized alpha-hydroxy acids. 5. The device of claim 1, wherein said third component further comprises at least one ceramic. 6. The device of claim 1, further comprising a fourth component arranged at an interface between said first and second regions. 7. The device of claim 6, wherein said fourth component comprises a film. 8. The device of claim 7, wherein said film is porous. 9. The device of claim 7, wherein said film is hydrophobic. 10. The device of claim 6, wherein said first region comprises a securement complex for the device, said second region comprises a regeneration complex, and said fourth component comprises interdigitations between the first and second regions. 11. The device of claim 1, wherein said device further comprises at least one additive selected from the group consisting of: composite elements, biologics, pharmaceuticals, or therapies. 12. The device of claim 11 wherein said additive is a composite element comprising ceramic. 13. The device of claim 12 wherein the ceramic is selected from at least one of the group consisting of calcium phosphate, calcium sulfate and triealcium phosphate. 14. The device of claim 11 wherein the additive is selected from at least one of the group consisting of antibiotics, anti-coagulants, anti-rejection agents, arteriogenesis agents, cells, chemotherapeutic agents, growth factors, hormones, morphogens or vitamins.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.