최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0055203 (2008-03-25) |
등록번호 | US-8425416 (2013-04-23) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 3 인용 특허 : 469 |
Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a
Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
1. A system for continuous measurement of a glucose concentration, the system comprising: a continuous glucose sensor comprising a first working electrode and a second working electrode, wherein the continuous glucose sensor is located at least in part in a fluid coupler configured to be in fluid co
1. A system for continuous measurement of a glucose concentration, the system comprising: a continuous glucose sensor comprising a first working electrode and a second working electrode, wherein the continuous glucose sensor is located at least in part in a fluid coupler configured to be in fluid communication with a vascular access device configured to be in fluid communication with a host's circulatory system;a flow control device configured to intermittently meter a glucose reference solution across the continuous glucose sensor such that the continuous glucose sensor intermittently measures the glucose concentration of the reference solution, and wherein the system is configured to calibrate the continuous glucose sensor using the measured glucose concentration of the reference solution; anda processor module operatively connected to the continuous glucose sensor and the fluid control device, wherein the processor module is configured to use a priori information to set tolerances for at least one of sensitivity drift or baseline drift. 2. The system of claim 1, wherein the processor module is configured to process signals from the first working electrode and second working electrode to obtain a substantially baseline-free glucose signal. 3. The system of claim 2, wherein the processor module is configured to calibrate the continuous glucose sensor using an equation that does not include a baseline parameter. 4. The system of claim 1, wherein the processor module is configured to use the measured glucose concentration of the reference solution to determine a sensitivity of the continuous glucose sensor. 5. The system of claim 4, wherein the processor module is configured to calibrate the continuous glucose sensor using the sensitivity of the continuous glucose sensor. 6. A system for continuous measurement of an analyte concentration, the system comprising: a continuous analyte sensor located in at least one of a vascular access device or a fluid coupler configured to be in fluid communication with a host's circulatory system;a flow control device configured to intermittently withdraw a blood sample from the host's circulatory system to the continuous analyte sensor; anda processor module operatively connected to the continuous analyte sensor and the flow control device, wherein the processor module is configured to use a priori information to establish at least one predetermined boundary set for a conversion function drawn from calibration. 7. The system of claim 6, wherein the flow control device is configured to intermittently meter a reference solution across the continuous analyte sensor such that the continuous analyte sensor is in continuous contact with either the reference solution or a blood sample from the host's circulatory system, and wherein the flow control device is configured to meter the reference solution such that the sensor is contacting the reference solution at least about 50% of the time during a sensor session. 8. The system of claim 7, wherein the flow control device is configured to meter the reference solution such that the sensor is contacting the reference solution at least about 80% of the time during a sensor session. 9. The system of claim 7, wherein the flow control device is configured to meter the reference solution such that the sensor is contacting the reference solution a sufficient amount of time such that biofouling does not occur for at least about 3 days of sensor use. 10. The system of claim 9, wherein the flow control device is configured to meter reference solution such that the sensor is contacting the reference solution a sufficient amount of time such that biofouling does not occur for at least about 7 days of sensor use. 11. The system of claim 10, wherein the flow control device is configured to meter reference solution such that the sensor is contacting the reference solution a sufficient amount of time such that biofouling does not occur for at least about 21 days of sensor use. 12. The system of claim 11, wherein the flow control device is configured to meter reference solution such that the sensor is contacting the reference solution a sufficient amount of time such that biofouling does not occur for at least about 30 days of sensor use. 13. The system of claim 9, wherein the sufficient amount of time is at least about 50% of the time during sensor use. 14. The system of claim 9, wherein the sufficient amount of time is at least about 65% of the time during sensor use. 15. The system of claim 9, wherein the sufficient amount of time is at least about 80% of the time during sensor use. 16. The system of claim 7, wherein the flow control device is configured to meter the reference solution through the vascular access device for a sufficient amount of time with a sufficient flow rate such that the vascular access device remains patent during a sensor session of at least about 3 days. 17. The system of claim 16, wherein the flow control device is configured to meter the reference solution through the vascular access device for at least about 50% of a sensor session, at a flow rate from about 0.001 ml/min to about 2 ml/min. 18. The system of claim 16, wherein the flow control device is configured to meter the reference solution through the vascular access device for at least about 65% of a sensor session, at a flow rate from about 0.5 ml/min to about 2 ml/min, whereby the vascular access device remains patent during a sensor session of from about 3 days to about 30 days.
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