Analytical rotors and methods for analysis of biological fluids
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-015/06
G01N-033/00
G01N-033/48
출원번호
US-0143070
(2009-12-30)
등록번호
US-8440147
(2013-05-14)
우선권정보
GB-0823660.6 (2008-12-30)
국제출원번호
PCT/PT2009/000081
(2009-12-30)
§371/§102 date
20110928
(20110928)
국제공개번호
WO2010/077159
(2010-07-08)
발명자
/ 주소
Garcia Da Fonseca, João
Esteves Reis, Nuno Alexandre
Burger, Robert
출원인 / 주소
Biosurfit, S.A.
대리인 / 주소
Patterson Thuente Pedersen, P.A.
인용정보
피인용 횟수 :
9인용 특허 :
41
초록▼
Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structu
Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a driving force. The discretization structure is shaped to define an outlet and a level to which the discretization structure fills with liquid flowing from the supply structure before dispensing the liquid at an outflow rate through the outlet in response to the driving force. The device is arranged such that the outflow rate from the discretization structure is greater than the inflow rate into the discretization structure, thereby periodically emptying the discretization structure to create a discretized flow from the outlet. The devices find applications in liquid mixing, for example for diluting samples, such as blood plasma samples.
대표청구항▼
1. A device for containing liquid, the device comprising: a first discretization structure; anda first supply structure for supplying, in response to a driving force, a first liquid at a first inflow rate to the first discretization structure;the first discretization structure being shaped to define
1. A device for containing liquid, the device comprising: a first discretization structure; anda first supply structure for supplying, in response to a driving force, a first liquid at a first inflow rate to the first discretization structure;the first discretization structure being shaped to define a first outlet and a first threshold level to which the first discretization structure fills with the first liquid before dispensing the first liquid, in response to the driving force, at a first outflow rate through the first outlet, the outlet being spaced from the first threshold level in the direction of the driving force;wherein the first outflow rate is greater than the first inflow rate, thereby periodically emptying the first discretization structure to create a discretized flow of the first liquid from the first outlet in response to the driving force. 2. A device as claimed in claim 1, wherein the first discretization structure comprises a conduit in fluidic communication with the first supply structure at one end and defining the first outlet at the other end, the conduit comprising a bend between the two ends defining the threshold level, the one end being closer to the bend than the other end. 3. A device as claimed in claim 2, wherein the conduit comprises a further bend between the one end and the bend and the first discretization structure comprises a volume in fluidic communication with the supply structure and, through a port disposed to allow complete emptying of the volume through the conduit, in fluidic communication with the one end of the conduit. 4. A device as claimed in claim 2, the device being adapted for rotation about an axis, the one end being radially outward of the bend and the other end being radially outward of the one end. 5. A device as claimed in claim 3, arranged for rotation about an axis, the one end being radially outward of the bend and the other end and further bend being radially outward of the one end; the port being located at a radially outmost aspect of the volume. 6. A device as claimed in claim 1, wherein the first outlet is configured to provide a surface tension energy barrier to flow of the liquid, thereby retaining liquid in the discretization structure until the liquid reaches the first threshold level. 7. A device as claimed in claim 6, wherein liquid flowing through the first outlet experiences a sudden change in at least one dimension of the outlet to anchor a front of the liquid or by modifying the surface properties of the structure within or adjacent the outlet. 8. A device as claimed in claim 7, wherein the sudden change in at least one dimension is a sudden expansion. 9. A device as claimed in claim 6, wherein the discretization structure comprises a modified surface region of differing surface properties to an adjacent surface region within or adjacent the first outlet. 10. A device as claimed in claim 9, wherein the modified surface region is hydrophobic and the adjacent surface region is wetted by an aqueous liquid. 11. A device as claimed in claim 1, the device further comprising: a second discretization structure;a second supply structure for supplying, in response to a driving force, a second liquid at a second inflow rate to the second discretization structure; anda mixing chamber,the second discretization structure being shaped to define a second outlet and a second threshold level to which the second discretization structure fills with the second liquid before dispensing the second liquid, in response to the driving force, at a second outflow rate, greater than the second inflow rate, through the second outlet;wherein the first and second outlets are in fluidic communication with the mixing chamber for receiving the first and second liquids, thereby allowing the liquids to mix. 12. A device as claimed in claim 11, wherein the first and second discretization structures are in fluidic communication with one another inside a common volume which, in use when the first and second supply structures are filled with the respective liquid, is only vented through the mixing chamber. 13. A device as claimed in claim 11, comprising an intermediate chamber in fluidic communication with the first and second outlets and having a single outlet in fluidic communication with the mixing chamber. 14. A device as claimed in claim 13, wherein the intermediate chamber defines a bubble removing feature adjacent the first outlet, arranged to capture liquid membranes formed at the first outlet after interruption of flow of the first liquid as the second liquid flows into the intermediate chamber. 15. A device as claimed in claim 14, wherein the feature is further arranged to guide bubbles formed by capturing of successively formed membranes away from the first outlet. 16. A device as claimed in claim 15, wherein the feature has a corner adjacent the first outlet disposed to be contactable by liquid issued from the second outlet and extending away from the first outlet of the first discretization structure to define a channel for guiding bubbles away from the corner. 17. A device as claimed in claim 16, wherein the channel widens with distance from the corner. 18. A device as claimed in claim 11, wherein the first and second supply structures are configured such that the first and second inflow rates form a ratio corresponding to a predetermined mixing ratio. 19. A device as claimed in claim 18, wherein the discretization structures are shaped such that a volume issued from the first outlet when the first liquid reaches the first threshold level and a volume issued from the second outlet when the second liquid reaches the second threshold level form a ratio corresponding to the predetermined mixing ratio. 20. A device as claimed in claim 18, wherein the first and second supply structures each comprise a reservoir shaped such that the respective liquid heads change at the same rate when each reservoir is emptied at the corresponding inflow rate. 21. A device as claimed in claim 11, the device further comprising: a third discretization structure;a third supply structure for supplying, in response to a driving force, a third liquid at a third inflow rate to the third discretization structure,the third discretization structure being shaped to define a third outlet and a third threshold level to which the third discretization structure fills with the third liquid before dispensing the third liquid, in response to the driving force, at a third outflow rate, greater than the third inflow rate, through the third outlet; anda fourth discretization structure,wherein the first and second outlets are in fluidic communication with the fourth discretization structure, the fourth discretization structure being shaped to define a fourth outlet and a fourth threshold level to which the fourth discretization structure fills with the first and second liquid before dispensing the first and second liquids, in response to the driving force, at a fourth outflow rate, greater than the fourth inflow rate, through the fourth outlet; and wherein the third and fourth outlets are in fluidic communication with the mixing chamber for receiving the first, second and third liquids, thereby allowing the liquids to mix. 22. A device as claimed in claim 21 wherein the first and second supply structures each define an interface with the corresponding discretization structure such that fluid flow stops at the interface when the driving force is not applied to the liquid; and the third supply structure comprises blocking means for releasably blocking liquid flow to the third discretization structure when the driving force is not applied to the liquid and a conduit connecting the blocking means to the third discretization structure; wherein the conduit is arranged such that when the driving force is applied the transit time of the third liquid from the blocking means to the third discretization structure is substantially the same as the transit time of the first and second liquids from the interface to the fourth discretization structure. 23. A device as claimed in claim 21, wherein the second and third supply structures include a common aliquoting structure for aliquoting respective volumes of the second and third liquid from a common reservoir. 24. A device as claimed in claim 11, wherein the first liquid is blood plasma and the first supply structure comprises means for receiving a blood sample and separating the blood plasma from the blood sample. 25. A device as claimed in claim 1, wherein the device is a microfluidic device. 26. A device as claimed in claim 1, wherein the device defines an axis of rotation and is rotatable about the axis to provide the driving force. 27. A device as claimed in claim 1, wherein the device is disc-shaped.
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